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This Commentary aims to integrate or interrelate the available in vivo data with the in vitro study by Ren and co-workers, which comes to the somewhat surprising conclusion that tubuloglomerular feedback activation vasodilates the efferent arteriole by an adenosine-dependent mechanism.Kidney International (2007) 71, 837–839. doi:10.1038/sj.ki.5002199 [ABSTRACT FROM AUTHOR]

Increases in luminal NaCl concentration at the macula densa (MD), the sensing element, activate tubuloglomerular feedback (TGF). MD cell volume increases when increments are isosmotic and shrinks if osmolality increases. This interesting finding introduces additional complexity to the role of the MD in TGF.Kidney International (2006) 70, 828–830. doi:10.1038/sj.ki.5001739 [ABSTRACT FROM AUTHOR]