Search

Introduction: Social jetlag is associated with several negative health outcomes, but its impact on asthma control has not been previously investigated. Although impaired sleep is common in asthma, studies on the relationship between sleep quality, social jetlag and asthma control in adolescents are scarce.Objective: To investigate the relationship between asthma control and sleep quality, sleep-wake pattern and excessive daytime sleepiness in adolescents.Methods: This was a cross-sectional study of 1457 Brazilian high-school adolescents. Asthma was identified using the International Study of Asthma and Allergies in Childhood questionnaire, and disease control was measured by the Asthma Control Test. Sleep-wake pattern and social jetlag were assessed by the Munich Chrono-Type Questionnaire; sleep quality, by the Pittsburgh Sleep Quality Index; and daytime sleepiness, by the Epworth Sleepiness Scale.Results: Asthma was present in 250 (17.2%) participants and was classified as uncontrolled in 120 (47.9%). Both uncontrolled and controlled asthma groups, compared with non-asthmatics, had worse sleep quality (81.7% vs 77.4% vs 56.5%; p < 0.001) and excessive daytime sleepiness (EDS: 56.2% vs 56.5% vs 39.2%; p < 0.001). On average, adolescents with uncontrolled asthma, compared to non-asthmatics, showed later sleep onset (mean ± SD: 23:54pm ± 1 h:45min vs 23:20pm ± 1 h:27min; p = 0.002) and shorter sleep duration (5.7 h ± 1.8 h vs 6.3 h ± 1.4 h; p = 0.002) on school days. No significant difference in social jetlag was found among the three groups.Conclusions: Asthma is associated with EDS and poor-quality sleep in adolescents. Social jetlag is common in these subjects and is not related to the presence and control of asthma. [ABSTRACT FROM AUTHOR]

Abstract: Background: Despite being frequently described in patients with end-stage renal disease (ESRD), clinical characteristics and comorbidities in association with restless legs syndrome (RLS) are still to be confirmed. Objectives: The aim of this study was to investigate clinical factors associated with RLS in ESRD patients in hemodialysis. Methods: This is a cross-sectional study of 400 patients on hemodialysis, evaluating RLS, clinical features and other sleep abnormalities. Results: Out of 400, 86 patients presented RLS (21.5%; mean age 48.8±13.8y), being more frequent in females (p <0.005). Forty-eight individuals (12% mean age 50.7±13.1y) had moderate/severe RLS, 14 reported symptoms prior to hemodialysis, 13 described family history of RLS, and eight described symptoms as disturbing during dialysis. RLS cases showed lower hemoglobin (p <0.005), poorer quality of sleep (Pittsburgh Sleep Quality Index >5, p =0.002), higher scores on the Beck Depression Inventory Scale (p <0.005), greater scores on the Charlson Comorbidity Index (p =0.01) and the Epworth Sleepiness Scale (p =0.001) and higher risk of obstructive sleep apnea (OSA; Berlin questionnaire, p =0.01). Hypertension was more frequent in cases with moderate/severe RLS (p =0.01) and remained after controlling for the risk of OSA (p =0.02). Conclusion: In ESRD patients in hemodialysis, RLS is present in 21.5%; 16% report symptoms prior to hemodialysis and a family history of RLS. Symptoms are disturbing during hemodialysis in 9% of cases. RLS is associated with lower hemoglobin, worse sleep quality, excessive daytime sleepiness, depressive symptoms and higher risk of OSA. Hypertension is associated with moderate/severe RLS. [ABSTRACT FROM AUTHOR]