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The article presents a study which showed that transposon expansions in Caenorhabditis (C.) nematodes led to extensive rewiring of germline transcriptional regulation. Topics discussed include generation of C. briggsae ATAC-seq and nuclear RNA-seq data, identification of germline-specific accessible sites in C. elegans and C. briggsae, and annotation of germline-specific promoters in C. elegans and C. briggsae.

Chromatin composition differs across the genome, with distinct compositions characterizing regions associated with different properties and functions. Whereas many histone modifications show local enrichment over genes or regulatory elements, marking can also span large genomic intervals defining broad chromatin domains. Here we highlight structural and functional features of chromatin domains marked by histone modifications, with a particular emphasis on the potential roles of H3K27 methylation domains in the organization and regulation of genome activity in metazoans. [ABSTRACT FROM AUTHOR]

The article features Sonia Delaunay, a key figure in the Parisian avant-garde, whose work spanned painting, fashion and design. It says that an exhibition of her works by Tate Modern in London, England in 2015 gave an assessment of her importance as artist, showcasing her originality and creativity across the twentieth century.

The article reviews an exhibition of the world's greatest collections of Kazimir Malevich's work which provided an expansive view of his career and explored his collaborative involvement with architecture and theatre.

There is compelling evidence that general practice (GP) is the most effective form of healthcare. However, healthcare policy appears independent of evidence and GP is woefully under-resourced in all countries, and this affects recruitment. Recruitment to GP is proportional to the quantity and quality of undergraduate experience and national and transnational guidelines can improve undergraduate experiences by defining both the desired quantity and quality. There is good evidence that these professionally developed guidelines can be effective in changing Government policy if they are used as a touchstone to collaborate with policymakers. EURACT (European Academy of Teachers in General Practice / Family Medicine) have therefore developed transnational guidelines covering the European region. The guidelines cover the desired quantity, quality and support for undergraduate experience. Three main design principles have been used. Firstly, it is democratic. Secondly it is evidence-based, using extensive literature searching, situational analysis and surveys. Finally, it adopts a 'principles-based approach'. Generalist medicine is articulated as a series of interconnected principles that integrate and then re-focus specialist medicine to achieve the enhanced patient-orientated outcomes of primary-care. This way of articulating generalist practice delivers general principles, which can be used as learning outcomes, that are adaptable to a wide range of learning environments. Most clinical learning documents are irrelevant and are destined for dusty drawers or forgotten digital files. We therefore encourage primary care educators to use these guidelines to work with policy-makers at all levels to advocate for change, strengthening primary care education at local, national and international levels. [ABSTRACT FROM AUTHOR]

Barrett's esophagus is a chronic gastroenteric disease that may cause a significant decrease in quality of life. This case presentation will discuss treatment of Barrett's esophagus by a family physician including the family physician's role in the management of such a patient and the importance of an immediate diagnostic strategy. [ABSTRACT FROM AUTHOR]

In industrialized countries, the exposure to medical diagnostic radiation is continuously rising. There are several evidences that high doses of those radiation correspond to increased risk of cancer. Nowadays we are facing an abuse of imaging tests. In this article we will first describe the risks of this abuse and second we will focus on the role of the family doctor in trying to reduce this problem [ABSTRACT FROM AUTHOR]

The case study is about a 72 years old patient who came to our practice complaining about otalgy and left hypoacusis. The patient went through different examinations and different medical therapies. At the end, she went through an operation of myringoplasty on both ears. The case seemed to be solved, but after a few months, she went through further complications. The manuscript describes in details all the measures and treatments carried out for the solution of the problem. [ABSTRACT FROM AUTHOR]

Interactive and multimedia methods are the future, already developing in teaching and learning modules in Medicine. It happens and has to happen because: 1) It improves tools for the teacher in preparing and showing the bulk of materials on which students must study and learn; it enables interactivity with learners both in formative pathway and in final assessment. 2) It improves attention, interest and involvement of students and learners, and acts as a guideline to progressive broadening in researches, studies, considerations, and information exchanges among different learners. 3) The rapid progress in application of technology, WEB area and sources researches allows such a deepening and widening interactivity that before was never possible to imagine. It is the same thing also in CME, sometimes so dry, and dropped from above, while the new methodology may/must get rid of negative and boring features, often not useful in producing particular improvements in knowledge and quality. The Professional Doctor needs to feel a protagonist part in situation to be investigated, where interaction with all what media tools can offer may produce an “educative” improvement, much faster, effective and pleasant/rewarding. [ABSTRACT FROM AUTHOR]

The article reviews the art exhibition, that showcases the paintings of Bohemian painter Henri Toulouse-Lautrec, at the Museum of Arts in Budapest, Hungary.

The article discusses the exhibition for artist Egon Schiele's paintings dedicated for war hospital nurse Wally Neuzil shown at the Leopold Museum in Vienna, Austria.

Presents a letter to the editor in the March 20, 2004 issue of the "British Medical Journal." Problems with suspensions of doctors that are badly performed; Discussion of the structure of health care in Italy.

Presents a letter to the editor regarding the tendency for doctors to be labelled as criminals in European society.

Fifteen years ago, a European survey demonstrated widespread adoption of early clinical exposure (ECE) programmes but little emphasis in the curricula of medical schools. We now repeat the survey in light of the ample emerging data suggesting multiple positive outcomes of ECE. Online cross-sectional survey in European medical schools conducted by the EURACT Basic Medical Education Committee in 2021. Descriptive quantitative analyses and a thematic analysis approach were used. Eighy-nine (48%) medical schools in 30 European countries responded. ECE was used in 65 (73%) of the medical schools, and 88% of ECE programmes took place in primary care. The median total time spent on the ECE programme was 5 days. Teaching methods covered unstructured learning opportunities such as observation or shadowing doctors, as well as work-based learning whilst seeing real patients or reflecting on own encounters. Learning goals included knowledge, skills, and attitudes. More than half of the respondents expressed barriers to implementing or expanding ECE. Compared to the previous survey, there was no significant change in the adoption or curricular emphasis of ECE programmes. Institutional attitudes towards certain disciplines and a lack of willingness to experiment with new teaching methods may be partially responsible. [ABSTRACT FROM AUTHOR]

Atopic dermatitis (AD) is a chronic remitting‐relapsing inflammatory skin disorder. Due to the multifactorial pathogenesis, there are numerous therapeutic management approaches, mainly based on symptomatic treatments. In recent years, allergen immunotherapy (AIT) has been progressively advanced as targeted disease‐modifying treatment of allergic disease. The most recent guideline from the American Academy of Dermatology concludes that data available do not support its use in AD. The Joint Task Force and The European Academy of Dermatology suggest that clinicians can consider AIT treatment in selected patients characterized by aeroallergen sensitization, prevalently HDM, severe AD, and clinical exacerbation after exposure to the causative allergen. Nevertheless, its role in AD is still under debate, especially in children. [ABSTRACT FROM AUTHOR]

This paper summarises a ten-year conversation within London Journal of Primary Care about the nature of community-oriented integrated care (COIC) and how to develop and evaluate it. COIC means integration of efforts for combined disease-treatment and health-enhancement at local, community level. COIC is similar to the World Health Organisation concept of a Community-Based Coordinating Hub - both require a local geographic area where different organisations align their activities for whole system integration and develop local communities for health. COIC is a necessary part of an integrated system for health and care because it enables multiple insights into 'wicked problems', and multiple services to integrate their activities for people with complex conditions, at the same time helping everyone to collaborate for the health of the local population. The conversation concludes seven aspects of COIC that warrant further attention. [ABSTRACT FROM AUTHOR]

Background: Substantial variations are still to be found in the strength of general practice/family medicine (GP/FM) across Europe regarding governance, workforce competence and performance, as well as academic development and position. Governments are encouraged by the WHO to secure high quality primary health care to their population, a necessity for reaching the goal "Health for all". The present study aimed at investigating the opinions of council members of the European Academy of Teachers in General Practice (EURACT) on necessary actions to strengthen the position of GP/FM in their country. Methods: The study used a mixed methods exploratory sequential design. EURACT representatives from 32 European countries first participated in brain-storming on how to strengthen GP/FM in Europe. Later, representatives from 37 countries were asked to individually score the relevance of the proposed actions for their country on a 9-point Likert scale. They were also asked to evaluate the status of GP/FM in their country on four dimensions. Results: Respondents from 30 European countries returned complete questionnaires. To build and secure GP/FM as an academic discipline comprising teaching and research was seen as essential, regardless the present status of GP/FM in the respective country. To build GP/FM as a specialty on the same level as other specialties was seen as important in countries where GP/FM held a strong or medium strong position. The importance of common learning objectives and a defined bibliography were stated by respondents from countries where GP/FM presently has a weak position. Conclusions: In order to strengthen GP/FM throughout Europe, EURACT and other professional organizations must establish common goals and share expertise between countries. To influence decision makers through information on cost-effectiveness of a GP/FM-based health care system is also important. [ABSTRACT FROM AUTHOR]