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This study describes the techniques used for the synthesis and characterization of mononuclear, heterocyclic ligated complexes of Zn(II), Mn(II), and Sn(II). A heterocyclic Schiff base derivative, specifically (E)-2-((benzo[b]thiophen-3-yl)methyleneamino)butanoic acid, has been synthesized by the reaction of benzo[b]thiophene-3-carbaldehyde with 2-aminobutanoic acid. This Schiff base has been reacted with different (M)Cl2 to synthesize the respective metal complexes. For these metal ions, Schiff bases have been proven experimentally to form four-coordinate complexes with 1 : 2 (metal : ligand) ratio. The structural changes of the complexes have been investigated using FT-IR, mass, 1H NMR, 13C NMR spectra, and TGA analysis. The antibacterial efficacy of the Schiff base and its complexes has further been assessed and discussed. Significant amounts of antibacterial and antifungal activity of metal(II) complexes against tetracycline and ketoconazole have been identified. [ABSTRACT FROM AUTHOR]

A ligand has been synthesized from 1-(1-methyl-5-(tosylamino)-1H-1,2,3-triazol-4-yl)ethanone and dimethylpyrimidyl hydrazone, and its copper(II), nickel(II), and zinc(II) complexes have been produced and analyzed. The X-ray diffraction analysis shows that the zinc(II) combination with the N3O donor ligand environment has the form of a tetragonal pyramid. The chelate core of the copper(II) complex is structurally identical, as shown by X-ray data. The coordination core of the nickel(II) complex is an octahedron, which is completed by the solvent molecule. Pharmacological evidence of antibacterial activity was obtained for all the substances. The synthetic compounds have been studied and compared to existing antibiotics like chloramphenicol and amphotericin B for their ability to kill bacteria and fungi, respectively. [ABSTRACT FROM AUTHOR]