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Summary: Severe but regressive toxic liver damage was observed in a 30-week pregnant woman due to acetaminophen poisoning. A cesarean section was performed 1 week later for suspected chorioamniotitis and the patient gave birth to an infant who only experienced complications of preterm birth. The lack of fetal liver damage following acute maternal paracetamol poisoning seems to be the rule, as shown by a review of the literature. [ABSTRACT FROM AUTHOR]

Abstract: Iron chelators and nuclear magnetic resonance imaging (MRI) techniques for assessing iron loading in liver and heart have greatly improved survival of thalassemic patients suffering iron overload-associated cardiomyopathy. However, the correlation between liver iron concentration and myocardial siderosis is ambiguous. Using an objective metric of time delay, scientists have demonstrated a lag in the loading and unloading of cardiac iron with respect to that of the liver. In the present study, we further tested this hypothesis with different chelation treatments. We analyzed the effect of three chelating treatment approaches on liver and cardiac iron content in 24 highly compliant patients who underwent 3 or more MRIs under each chelation treatment. Of the 84 MRIs considered, 32 were performed on deferoxamine (DFO — 8 patients), 24 on deferiprone (DFP — 7 patients), and 28 on combined therapy (DFO+DFP — 9 patients). In patients treated with DFO, changes in cardiac iron significantly lagged changes in liver iron but the opposite pattern was observed in patients treated with DFP (p=0.005), while combined therapy showed a pattern in-between DFO and DFP. We conclude that the temporality of changes of cardiac and liver iron is chelator-dependent, so that chelation therapy can be tailored to balance iron elimination from the liver and the heart. [Copyright &y& Elsevier]

Poster: Clinical track: Other PO-1291: Management of pain in Radiotherapy Departments: preliminary results of an observational study C.M. Donati, I. Zamagni, A. Zamagni, E. Galofaro, G. Siepe, E. Scirocco, M. Buwenge, F. Cellini, A. Di Rito, C. De Tommaso, A. Santacaterina, R. Di Franco, S. Cossa, A.G. Morganti, S. Cammelli. [Extracted from the article]