1. Glicozidele cardiace – trecut, prezent, viitor.
- Author
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Bacinschi, Nicolae, Nica, Loredana, Rakovskaia, Tatiana, Guțu, Ina, and Caracaș, Anastasia
- Abstract
Cardiotonic steroids, predominantly known as cardiac glycosides, are a group of compounds found in plants and animals, but also synthesized by the human body. Cardiac glycosides, a class of organic compounds with a long history of use of over 200 years in medicine, are known as prescribed preparations for the treatment of heart failure with reduced ejection fraction and supraventricular tachyarrhythmias. In the last two decades, studies have been reported attributing to cardiotonic steroids the function of hormones involved in the regulation of cell growth and differentiation, apoptosis and fibrosis, modulation of immunity and carbohydrate metabolism, control of central nervous system functions and behaviour. Recent research on cardiotonic steroids has focused on identifying specific compounds in animals and humans, determining changes in their concentrations and their role in human disease states, discovering the cellular signaling functions of Na+/K+-ATPase and its involvement in many aspects of basic cell biology. Of note, recent studies have reported a number of pharmacological effects, such as antitumor, antiviral, neuroprotective and immunomodulatory, and the possibility of research and development of new drugs with possible use in the treatment of tumors, viral infections, neurological, inflammatory and immune disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2024