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In correlated oxides, collaborative manipulation on light intensity, wavelength, pulse duration and polarization has yielded many exotic discoveries, such as phase transitions and novel quantum states. In view of potential optoelectronic applications, tailoring long-lived static properties by light-induced effects is highly desirable. So far, the polarization state of light has rarely been reported as a control parameter for this purpose. Here, we report polarization-dependent metal-to-insulator transition (MIT) in phase-separated manganite thin films, introducing a new degree of freedom to control static MIT. Specifically, we observed giant photoinduced resistance jumps with striking features: (1) a single resistance jump occurs upon a linearly polarized light incident with a chosen polarization angle, and a second resistance jump occurs when the polarization angle changes; (2) the amplitude of the second resistance jump depends sensitively on the actual change of the polarization angles. Linear transmittance measurements reveal that the origin of the above phenomena is closely related to the coexistence of anisotropic micro-domains. Our results represent a first step to utilize light polarization as an active knob to manipulate static phase transitions, pointing towards new pathways for nonvolatile optoelectronic devices and sensors. [ABSTRACT FROM AUTHOR]

The purpose of this work was to analyze and evaluate the functional properties of a new nanoemulsion that contained cordycepin. Droplet size and distribution were measured, and the stability of the nanoemulsion in different storage conditions was evaluated. We also tested skin irritation caused by the nanoemulsion, cordycepin stability in the nanoemulsion, anti-aging effect, and microbial challenge. The nanoemulsion was homogeneous with proper dispersion stability, and cordycepin was stable for eight months within the cosmetic nanoemulsion. The nanoemulsion did not irritate human hand and face skin, and the cosmetic nanoemulsion was effective in preventing microbial contamination of the product during use and storage. The new nanoemulsion containing cordycepin satisfied provisions of the 2015 Safety and Technical Standards for Cosmetics of the Ministry of Health, People's Republic of China. [ABSTRACT FROM AUTHOR]

Popularizing contemporary Chinese Marxism is urgently needed in order to support the ongoing development of socialism with Chinese characteristics as well as the inherent necessity of Marxism. This essay views the popularization of Marxism as a turning point in the new media environment. It examines the necessity and reality of this popularization in the new media era, considers the new development needs of the popularization of Marxism in propaganda, and further unearths the original construction concepts of the popularization of the Marxism propaganda network. In parallel, a Marxist learning platform is built using data mining technology. Studies reveal that this algorithm has a high clustering accuracy and a recall rate that is about 6% higher than DECluster's. Additionally, this algorithm takes less time to execute under the same scale transaction set. This demonstrates the superior performance of this algorithm. The user's learning record and learning interests can be formed into an intuitive law using the algorithm presented in this study, which can be used to analyze and calculate the user's learning content related to Marxism. This law can then be used to assist the user in creating a customized learning plan for Marxism. [ABSTRACT FROM AUTHOR]

Naoxintong capsule (NXT) is one of the most prevalent Traditional Chinese Medicine formulations in the treatment of coronary heart disease (CHD), yet the action of pharmacodynamic components remains unclear. To determine the basis by which pharmacodynamic components of NXT may be effective in the treatment of CHD. The protective effect of NXT (0.01–100 μg/mL) on 293 T and hy926 cells was determined by MTT assay for 24 h. Afterwards, to investigate the pharmacodynamic material basis of NXT in anti-inflammatory and antioxidant effects, based on previous UPLC/Q-TOF analysis, 293 T and hy926 cells were divided into control (treated with solvent), model (incubated with TNF-α, LPS or H2O2), intervention (treated with UPLC components) and positive groups. After 24 h of treatment, all cells were tested to verify the screening results. MOE software was applied to dock bioactive compounds with phosphoinositide 3-kinase (PI3K), then the protein expression and phosphate levels were determined by western blotting. NXT could significantly inhibit the expression of NF-κB, MMP-9 and NO in cells with IC50 values of 0.1178, 0.1182 and 0.1094 μg/mL. Based on the screening results, six components of NXT were identified (calycosin, ferulic acid, salvianolic acid B, ononin, salvianolic acid E, and salvianolic acid F) which can inhibit NF-κB, MMP-9, and NO simultaneously, while exerting cytoprotective effects by inhibiting the activation of the PI3K/AKT pathway under different conditions by virtue of their advantageous interaction with PI3K. These ingredients have outstanding therapeutic potential and may provide a scientific basis for the future application and research of NXT. [ABSTRACT FROM AUTHOR]

Electronic phase separation in complex oxides is the inhomogeneous spatial distribution of electronic phases, involving length scales much larger than those of structural defects or nonuniform distribution of chemical dopants. While experimental efforts focused on phase separation and established its correlation with nonlinear responses under external stimuli, it remains controversial whether phase separation requires quenched disorder for its realization. Early theory predicted that if perfectly "clean" samples could be grown, both phase separation and nonlinearities would be replaced by a bicritical-like phase diagram. Here, using a layer-by-layer superlattice growth technique we fabricate a fully chemically ordered "tricolor" manganite superlattice, and compare its properties with those of isovalent alloyed manganite films. Remarkably, the fully ordered manganite does not exhibit phase separation, while its presence is pronounced in the alloy. This suggests that chemical-dopinginduced disorder is crucial to stabilize the potentially useful nonlinear responses of manganites, as theory predicted. [ABSTRACT FROM AUTHOR]

Three-dimensional printing (3D printing) technology based on slurry extrusion makes it possible to realize rapid manufacture of personalized, refined and complex ceramic products. The ceramic slurry for extrusion molding which is affected by various factors requires excellent extrusion properties and shape retention capacity. In this paper, the methods of orthogonal experiment design (OED) and back propagation artificial neural networks (BP ANNs) were combined to solve multi-objective and multi-factor problems caused by the preparation of alumina slurry. Through the combined model, the relationship between extrusion parameters and influencing factors of the slurry was obtained. The predicted optimal values were consistent with the experimental results, which proves the validity of the model. Alumina slurry suitable for 3D printing with excellent extrusion and shape retention properties was successfully prepared. The method is also applicable to the study of other multi-objective and multi-factor ceramic materials. [ABSTRACT FROM AUTHOR]

Based on the nature of wind, wind power fluctuations can cause significant problems in the distribution network. One of the solutions is to integrate an energy storage system with wind farm to mitigate the output power fluctuations. Therefore, an energy storage coordinated control strategy based on model predictive control is proposed to smooth minute-scale fluctuations of wind power. By analysing the limitations of traditional control strategy, four operating modes of battery energy storage system which are determined by the predicted state of charge obtained by model predictive control, are designed to avoid violating the state of charge limitation, and an energy state feedback control is designed to adjust the initial power allocation orders of batteries. Finally, the effectiveness of the proposed control strategy can be verified by the real-time digital simulator. The results indicate that the developed approach reduces the switching times of batteries and improves the ability of the battery energy storage system to smooth wind power fluctuations significantly. [ABSTRACT FROM AUTHOR]

Chaetominine (CHA), an alkaloid with a biological activity obtained from Aspergillus fumigatus CY018, has strong anticancer activity against the human leukemia cells. However, its physiological and biochemical research is limited by CHA yield in the liquid‐state fermentation, which is a problem that urgently needs effective biological solution. In this work, Ca2+ and Al3+ were found to have a strong promoting effect on CHA production after multiple metal ions screening. Then, the addition condition of Ca2+ and Al3+ was, respectively, optimized CHA production and dry cell weight. The intermediate metabolites were increased with coaddition of Ca2+ and Al3+. The activities of key enzymes of DAHPs, AroAs, and TrpCs in the CHA biosynthesis pathway were improved by 3.58‐, 3.60‐, and 3.34‐fold, respectively. Meanwhile, the transcription level of laeA, dahp, cs, and trpC was upregulated by 3.22‐, 12.65‐, 5.58‐, and 6.99‐fold, respectively, by coaddition of Ca2+ and Al3+. Additionally, the fermentation strategy was successfully scaled up to a 5‐L bioreactor, in which CHA production could attain 75.6 mg/L at 336 h. This work demonstrated that Ca2+ and Al3+ coaddition was an effective strategy for increasing CHA production, and the information obtained might be useful in the fermentation of filamentous fungi with the addition of metal ions. [ABSTRACT FROM AUTHOR]

• A pin-by-pin method of rectangular mesh based on quasi-diffusion theory was developed. • A MOC-based deterministic code ALPHA was developed to generate the Eddington factor. • This pin-by-pin method has similar accuracy as P3 and similar efficiency as diffusion calculation. With the development of nuclear energy techniques, pin-by-pin calculation using the SP3 method based on pin cell homogenization attracts researchers. This study proposed a pin-by-pin calculation method of rectangular mesh based on quasi-diffusion (QD) theory. The QD equation and boundary condition were derived from a transport equation similar to the P1 equation derivation. The Eddington factor was treated as a few-group homogenized parameter and calculated based on a deterministic code ALPHA. The numerical method of QD equation was developed based on nodal expansion method of nonlinear iteration. Some benchmarks were used to verify the Eddington factor and the numerical method of QD. 4 colorset models with different neutron anisotropy levels were analyzed by pin-by-pin-QD method. Pin-by-pin-QD can reduce k eff error by about 600 pcm and agree better with reference results. Additionally, it has better accuracy and similar efficiency as diffusion calculation and is suitable for problems with strong anisotropy. [ABSTRACT FROM AUTHOR]

Bacterial infections of plants are widespread and highly virulent, causing serious economic losses in agricultural production worldwide. These infections become particularly prevalent during rainy weather, characterized by high humidity and low light intensity (about 2–10% of a sunny day). Here we identified a class of photosensitizers that were effective in inhibiting plant bacterial infections under rainy weather with dim light. One of these compounds, compound 1 , demonstrated exceptional efficacy by eliminating more than 4 logs (99.99%) of either Xanthomonas perforans or Xanthomonas citri subsp. citri (Xcc) strain at a concentration of 6.25 μM under rainy weather conditions with a light exposure of 28.51 J/cm2. For Clavibacter michiganensis (Cm), compound 1 demonstrated a comparable bactericidal effect at a lower concentration of 3.13 μM. Furthermore, compound 1 was effective in controlling plant leaf infections during rainy weather. Moreover, compound 1 exhibited a potent inhibitory effect on the biofilms pertinent to tomato spot disease and citrus canker under natural illumination on rainy days. Additionally, compound 1 displayed remarkable resilience to rain-wash on plant leaves, retaining 41.20% of its initial concentration following exposure to three simulated rain events. These findings provide a new strategy for plant pathogen disease management highlight its feasibility even during rainy weather. [Display omitted] • Bacterial infections in plants are more prevalent during overcast or rainy weather. • The limited illumination during overcast or rainy days restricts the application of photodynamic strategy in controlling bacterial infection. • A range of photosensitizers were synthesized. Compound 1 effectively controls infections in plants during overcast or rainy days. • Compound 1 also inhibits the formation of bacterial biofilms on plant surfaces. • Compound 1 exhibits rain resistance, maintaining a 41.2% efficacy even after rain wash. [ABSTRACT FROM AUTHOR]

Quaternary ammonium compounds (QACs) are inexpensive and readily available disinfectants, and have been widely used, especially since the COVID-19 outbreak. The toxicity of QACs to humans has raised increasing concerns in recent years. Here, a new type of QACs was synthesized by replacing the alkyl chain with zinc phthalocyanine (ZnPc), which consists of a large aromatic ring and is hydrophobic in nature, similar to the alkyl chain of QACs. Three ZnPc-containing disinfectants were synthesized and fully characterized. These compounds showed 15–16 fold higher antimicrobial effect against Gram-negative bacteria than the well-known QACs with half-maximal inhibitory (IC 50) values of 1.43 μM, 2.70 μM, and 1.31 μM, respectively. With the assistance of 680 nm light, compounds 4 and 6 had much higher bactericidal toxicities at nanomolar concentrations. Compound 6 had a bactericidal efficacy of close to 6 logs (99.9999% kill rate) at 1 μM to Gram-positive bacteria, including MRSA, under light illumination. Besides, these compounds were safe for mammalian cells. In a mouse model, compound 6 was effective in healing wound infection. Importantly, compound 6 was easily degraded at working concentrations under sunlight illumination, and is environmentally friendly. Thus, compound 6 is a novel and promising disinfectant. [Display omitted] • Quaternary ammonium compounds (QACs) degrade slowly in environment, causing health concerns. • A new type of QACs containing phthalocyanine group are synthesized. • New QACs degrade fast under environmental lighting. • New QACs show 15–16 times stronger bactericidal effect. • New QACs kill 6 logs of Gram-positive bacteria at 1 μM. [ABSTRACT FROM AUTHOR]

[Display omitted] • Non-alcoholic fatty liver disease is complex and includes many mechanisms. • CYP2E1 play a crucial role in non-alcoholic fatty liver disease. • CYP2E1 is involved in lipid metabolism and produces reactive oxygen species. • Flavonoids can inhibit the activity of CYP2E1 and alleviate oxidative stress level. Over the years, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased year by year; however, due to its complicated pathogenesis, there is no effective treatment so far. It is reported that Cytochrome P450 2E1 (CYP2E1) plays an indispensable role in the development of NAFLD, and numerous studies have shown that flavonoids have a hepatoprotective effect and can exert a beneficial effect on NAFLD by regulating the activity of CYP2E1. Therefore, flavonoids may become effective drugs for the treatment of NAFLD in the future. This prompted us to review the research progress of the pathological mechanism of NAFLD and the impact of CYP2E1 activity changes during the pathological process, and to summarize the protective effect of flavonoids against CYP2E1 activity. [ABSTRACT FROM AUTHOR]