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A series of substituted N‐(2‐Morpholinoethyl)‐3‐phenylquinoxalin‐2‐amines (5a–j) (5ab, 5ac) were synthesized in good yield and characterized for their structural confirmation. The pure quinoxaline products were screened for their in‐vitro antibacterial activity against Salmonella paratyphi, a well‐known food borne pathogen. The preliminary results revealed that among the series, compounds 5a, 5c, 5d, 5e, 5f, 5h, 5ab and 5ac bearing bromo, fluoro, methoxy, methyl groups at para position on phenyl ring which inturn substituted at third position of quinoxaline and methyl, benzoyl groups at sixth position on the quinoxaline were emerged as potential candidates by displaying antisalmonella activity. Among the potential candidates, compounds 5c, 5e, 5f and 5ac were effective against Salmonella whereas compounds 5a, 5f and 5ac effectively inhibited the biofilm formation of Salmonella. [ABSTRACT FROM AUTHOR]

This article discusses the need for new molecules with better antibacterial properties due to increasing drug resistance. The authors propose a copper-mediated synthesis of benzothiazoles, which have shown effectiveness against bacterial diseases. They present an efficient method for the synthesis of these compounds using copper oxide. The article also discusses the synthesis and antibacterial activity of the compounds, as well as their ability to inhibit biofilm formation. Compound 5r showed significant inhibitory effects and biofilm inhibition percentages comparable to a traditional antibiotic. Further research is needed to validate its therapeutic use. The document provides information on the synthesis and characterization of various compounds derived from benzo[d]thiazole. The compounds were tested against different bacteria strains and showed promising antibacterial and antibiofilm activities. Computational studies were conducted to analyze the interactions between the compounds and specific proteins. The authors acknowledge the support of the National Facility Single Crystal Laboratory. [Extracted from the article]