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Objective: Helicobacter pylori (H. Pylori) infection is related withgastroduodenal diseases, along with some autoimmune diseaseslike rheumatoid arthritis (RA). The present study investigated theaffect of H. pylori eradication treatment on disease activity inpatients with RA.Material and Methods: A total of 50 patients with RA were evaluatedby the CLO test and histological examination and divided into2 groups as H. pylori positive and negative. Eradication treatmentwas given to the H. pylori positive group for 14 days. Patients inboth groups were evaluated in terms of disease activity initiallyand at the 6th month.Results: The H. pylori positive and negative group consisted of 19and 31 patients, respectively and these groups were not statisticallysignificantly different in terms of age, disease duration, and gastrointestinalcomplaints (p>0.05). The evaluation of initial and 6thmonth clinical and laboratory parameters revealed no significantdifference between groups in terms of disease activity (p>0.05).Conclusion: The present study revealed no significant differencebetween H. pylori positive and negative patients in terms of dyspepticcomplaints and disease activity. [ABSTRACT FROM AUTHOR]