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BACKGROUND: Acute worsening of cardiac function frequently leads to kidney dysfunction. This study aimed to identify clinical and imaging parameters associated with impaired kidney function in patients with acute decompensated heart failure with reduced ejection fraction (HFrEF). METHODS: Data from 131 patients hospitalized with acute decompensated HFrEF (left ventricular ejection fraction, < 40%) were analyzed. Patients were divided into two groups according to the glomerular filtration rate (GFR) at admission (those with preserved kidney function [GFR ≥ 60 mL/min/1.73 m²] and those with reduced kidney function [GFR < 60 mL/min/1.73 m²]). Various echocardiographic parameters and perirenal fat thicknesses were assessed by computed tomography. RESULTS: There were 71 patients with preserved kidney function and 60 patients with reduced kidney function. Increased age (odds ratio [OR], 1.07; 95% confidence interval [CI], 1.04-1.12; p = 0.005), increased log N-terminal pro b-type natriuretic peptide (OR, 1.74; 95% CI, 1.14-2.66; p = 0.010), and increased perirenal fat thickness (OR, 1.19; 95% CI, 1.10-1.29; p < 0.001) were independently associated with reduced kidney function, even after adjusting for variable clinical and echocardiographic parameters. The optimal average perirenal fat thickness cut-off value of > 12 mm had a sensitivity of 55% and specificity of 83% for kidney dysfunction prediction. CONCLUSIONS: Thick perirenal fat was independently associated with impaired kidney function in patients hospitalized for acute decompensated HFrEF. Measurement of perirenal fat thickness may be a promising imaging marker for the detection of HFrEF patients who are more susceptible to kidney dysfunction. [ABSTRACT FROM AUTHOR]

This research aimed to correct recently changed surface characteristics into a diagnostic wind field model with the purposes of investigating the changed mixing depth and wind profile, as well as its impact on wind resource potentials. In order to reflect the latest surface characteristics, the Environmental Geographic Information System (EGIS) 3-s land-use data produced by the Ministry of Environment was inputted. A change in the conditions of the surface affects the local wind circulation and the feature of Planetary Boundary Layer (PBL), such as mixing heights and the wind speed profile. As a result, a difference of wind speed at a hub height leads to a change in the wind energy potential. Compared to Low Resolution experiment (LRexp), High Resolution experiment (HRexp) suffers Root Mean Square Error (RMSE) decreased by 26.3% and Index Of Agreement (IOA) is increased by 7.8% at maximum, so that it contributes to the improved prediction accuracy of wind field. [ABSTRACT FROM AUTHOR]

The article presents a study on the activation of activin receptor type-2A (Acvr2a) as a T helper cell (Th17 cell)-specific gene induced during Th17 differentiation. It states that the expression of Acvr2a was inhibited when Th17 cell differentiation was inhibited by all tarans retinoic acid (ATRA) that induces regulatory T cell (Treg) differentiation. Results show that Acvr2a is a Th17 specific gene making Th17 cells.

Nucleic acids, DNA and RNA, provide important fingerprint information for various pathogens and have significant diagnostic value; however, improved approaches are urgently needed to enable rapid detection of nucleic acids in simple point-of-care formats with high sensitivity and specificity. Here, we present a system that utilizes a series of toehold-triggered hybridization/displacement reactions that are designed to convert a given amount of RNA molecules (i.e., the analyte) into an amplified amount of signaling molecules without any washing steps or thermocy-cling. Fluorescent probes for signal generation were designed to consume products of the catalytic reaction in order to push the equilibrium and enhance the assay fold amplification for improved sensitivity and reaction speed. The system of toehold-assisted reactions is also modeled to better understand its performance and capabilities, and we empirically demonstrate the success of this approach with two analytes of diagnostic importance, i.e., influenza viral RNA and a micro RNA (miR-31). We also show that the amplified signal permits using a compact and cost-effective smartphone-based fluorescence reader, an important requirement toward a nucleic-acid-based point-of-care diagnostic system. [ABSTRACT FROM AUTHOR]

In this paper, a new wind resource assessment procedure for building-integrated wind turbines (BIWTs) is proposed. The objective is to integrate wind turbines at a 555 m high-rise building to be constructed at the center of Seoul, Korea. Wind resource assessment at a high altitude was performed using ground-based remote sensing (RS); numerical weather prediction (NWP) modeling that includes an urban canopy model was evaluated using the remote sensing measurements. Given the high correlation between the model and the measurements, we use the model to produce a long-term wind climate by correlating the model results with the measurements for the short period of the campaign. The wind flow over the high-rise building was simulated using computational fluid dynamics (CFD). The wind resource in Seoul-one of the metropolitan cities located inland and populated by a large number of skyscrapers-was very poor, which results in a wind turbine capacity factor of only 7%. A new standard procedure combining RS, NWP, and CFD is proposed for feasibility studies on high-rise BIWTs in the future. [ABSTRACT FROM AUTHOR]

Lipid raft-associated clathrin is essential for host-pathogen interactions during infection. Brucella abortus is an intracellular pathogen that circumvents host defenses, but little is known about the precise infection mechanisms that involve interaction with lipid raft-associated mediators. The aim of this study was to elucidate the clathrin-mediated phagocytic mechanisms of B. abortus. The clathrin dependence of B. abortus infection in HeLa cells was investigated using an infection assay and immu-nofluorescence microscopy. The redistribution of clathrin in the membrane and in phagosomes was investigated using sucrose gradient fractionation of lipid rafts and the isolation of B. abortus-containing vacuoles, respectively. Clathrin and dynamin were concentrated into lipid rafts during B. abortus infection, and the entry and intracellular survival of B. abortus within HeLa cells were abrogated by clathrin inhibition. Clathrin disruption decreased actin polymerization and the colocaliza-tion of B. abortus-containing vacuoles with clathrin and Rab5 but not lysosome-associated membrane protein 1 (LAMP-1). Thus, our data demonstrate that clathrin plays a fundamental role in the entry and intracellular survival of B. abortus via interaction with lipid rafts and actin rearrangement. This process facilitates the early intracellular trafficking of B. abortus to safe replicative vacuoles. [ABSTRACT FROM AUTHOR]

The use of BGA (Ball Grid Array) interconnects utilizing the lead-free solder joint has grown rapidly because of its small volume and diversity of application. Thus, it requires the continuous quantification and refinement of lead-free solder joint reliability. The lead-free solder creep and cyclically applied mechanical loads cause metal fatigue on the lead-free solder joint which inevitably leads to an electrical discontinuity. In the field application, BGA solder joints experience mechanical loads during temperature changes caused by power up/down events as the result of the CTE (Coefficient of Thermal Expansion) mismatch between the substrate and the Si die. In this paper, extremely small resistance changes at joint area corresponding to through-cracks generated by thermal fatigue were measured. In this way, the failure was defined in terms of anomalous changes in electrical resistance of the joint. Furthermore the reliability of BGA solder joints in thermal cycling is evaluated by using the modified coffin-Manson criterion which may define and distinguish failure. Any change in circuit resistance according to the accumulated damage induced by the thermal cycling in the joint was recorded and evaluated in order to quantitate reliability of solder joint. [ABSTRACT FROM AUTHOR]