1. “Pure by NMR”?
- Author
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Timothy D. W. Claridge, Stephen G. Davies, Mario E. C. Polywka, Paul M. Roberts, Angela J. Russell, Edward D. Savory, and Andrew D. Smith
- Subjects
- *
NUCLEAR magnetic resonance , *RESONANCE , *QUANTITATIVE chemical analysis , *SPECTRUM analysis , *DIASTEREOISOMERS , *STEREOCHEMISTRY - Abstract
Integration of a 13C−1H satellite peak of a given 12C−1H parent resonance within a quantitative 1H NMR spectrum and comparison to the minor component represents a simple protocol for the accurate determination of diastereoisomeric ratios of up to 1000:1 (i.e., 99.8% de). [ABSTRACT FROM AUTHOR]
- Published
- 2008
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