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The rapid growth of data generated by several applications like engineering, biotechnology, energy, and others has become a crucial challenge in the high dimensional data mining. The large amounts of data, especially those with high dimensions, may contain many irrelevant, redundant, or noisy features, which may negatively affect the accuracy and efficiency of the industrial data mining process. Recently, several meta-heuristic optimization algorithms have been utilized to evolve feature selection techniques for dealing with the vast dimensionality problem. Despite optimization algorithms' ability to find the near-optimal feature subset of the search space, they still face some global optimization challenges. This paper proposes an improved version of the sooty tern optimization (ST) algorithm, namely the ST-AL method, to improve the search performance for high-dimensional industrial optimization problems. ST-AL method is developed by boosting the performance of STOA by applying four strategies. The first strategy is the use of a control randomization parameters that ensure the balance between the exploration–exploitation stages during the search process; moreover, it avoids falling into local optimums. The second strategy entails the creation of a new exploration phase based on the Ant lion (AL) algorithm. The third strategy is improving the STOA exploitation phase by modifying the main equation of position updating. Finally, the greedy selection is used to ignore the poor generated population and keeps it from diverging from the existing promising regions. To evaluate the performance of the proposed ST-AL algorithm, it has been employed as a global optimization method to discover the optimal value of ten CEC2020 benchmark functions. Also, it has been applied as a feature selection approach on 16 benchmark datasets in the UCI repository and compared with seven well-known optimization feature selection methods. The experimental results reveal the superiority of the proposed algorithm in avoiding local minima and increasing the convergence rate. The experimental result are compared with state-of-the-art algorithms, i.e., ALO, STOA, PSO, GWO, HHO, MFO, and MPA and found that the mean accuracy achieved is in range 0.94–1.00. [ABSTRACT FROM AUTHOR]

Recently, The Egyptian health sector whether it is public or private; utilizes emerging technologies such as data mining, business intelligence, Internet of Things (IoT), among many others to enhance the service and to deal with increasing costs and growing pressures. However, process mining has not yet been used in the Egyptian organizations, whereas the process mining can enable the domain experts in many fields to achieve a realistic view of the problems that are currently happening in the undertaken field, and thus solve it. This paper presents application of the process mining techniques in the healthcare field to obtain meaningful insights about its careflows, e.g., to discover typical paths followed by certain patient groups. Also, to analyze careflows that have a high degree of dynamic and complexity. The proposed methodology starts by the preprocess step on the event logs to eliminate outliers and clean the event log. And then apply a set of the popular discovery miner algorithms to discover the process model. Then careflows processes are analyzed from three main perspectives: the control-flow perspective, the performance perspective and, the organizational perspective. That contributes with many insights for the domain experts to improve the existing careflows. Through evaluating the simplicity metric of extracted models; the paper suggested a method to quantify the simplicity metric. The paper used a dataset from a cardiac surgery unit in an Egyptian hospital. The results of the applied process mining techniques provide the hospital managers a real analysis and insights to make the patient journey easier. [ABSTRACT FROM AUTHOR]

Reliance on deep learning techniques has become an important trend in several science domains including biological science, due to its proven efficiency in manipulating big data that are often characterized by their non-linear processes and complicated relationships. In this study, Convolutional Neural Networks (CNN) has been recruited, as one of the deep learning techniques, to be used in classifying and predicting the biological activities of the essential oil-producing plant/s through their chemical compositions. The model is established based on the available chemical composition's information of a set of endemic Egyptian plants and their biological activities. Another type of machine learning algorithms, Multiclass Neural Network (MNN), has been applied on the same Essential Oils (EO) dataset. This aims to fairly evaluate the performance of the proposed CNN model. The recorded accuracy in the testing process for both CNN and MNN is 98.13% and 81.88%, respectively. Finally, the CNN technique has been adopted as a reliable model for classifying and predicting the bioactivities of the Egyptian EO-containing plants. The overall accuracy for the final prediction process is reported as approximately 97%. Hereby, the proposed deep learning model could be utilized as an efficient model in predicting the bioactivities of, at least Egyptian, EOs-producing plants. [ABSTRACT FROM AUTHOR]

Background: Nonalcoholic Steatohepatitis (NASH) results from complex liver conditions involving metabolic, inflammatory, and fibrogenic processes. Despite its burden, there has been a lack of any approved food-and-drug administration therapy up till now. Purpose: Utilizing machine learning (ML) algorithms, the study aims to identify reliable potential genes to accurately predict the treatment response in the NASH animal model using biochemical and molecular markers retrieved using bioinformatics techniques. Methods: The NASH-induced rat models were administered various microbiome-targeted therapies and herbal drugs for 12 weeks, these drugs resulted in reducing hepatic lipid accumulation, liver inflammation, and histopathological changes. The ML model was trained and tested based on the Histopathological NASH score (HPS); while (0–4) HPS considered Improved NASH and (5–8) considered non-improved, confirmed through rats' liver histopathological examination, incorporates 34 features comprising 20 molecular markers (mRNAs-microRNAs-Long non-coding-RNAs) and 14 biochemical markers that are highly enriched in NASH pathogenesis. Six different ML models were used in the proposed model for the prediction of NASH improvement, with Gradient Boosting demonstrating the highest accuracy of 98% in predicting NASH drug response. Findings: Following a gradual reduction in features, the outcomes demonstrated superior performance when employing the Random Forest classifier, yielding an accuracy of 98.4%. The principal selected molecular features included YAP1, LATS1, NF2, SRD5A3-AS1, FOXA2, TEAD2, miR-650, MMP14, ITGB1, and miR-6881-5P, while the biochemical markers comprised triglycerides (TG), ALT, ALP, total bilirubin (T. Bilirubin), alpha-fetoprotein (AFP), and low-density lipoprotein cholesterol (LDL-C). Conclusion: This study introduced an ML model incorporating 16 noninvasive features, including molecular and biochemical signatures, which achieved high performance and accuracy in detecting NASH improvement. This model could potentially be used as diagnostic tools and to identify target therapies. [ABSTRACT FROM AUTHOR]