1. Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study.
- Author
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Tabatabaei, N, Eren, AM, Barreiro, LB, Yotova, V, Dumaine, A, Allard, C, Fraser, WD, Eren, A M, Barreiro, L B, and Fraser, W D
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HUMAN microbiota , *VAGINA , *PREGNANCY , *PREMATURE labor , *HOST-bacteria relationships , *GRAM-negative bacteria , *PREMATURE infants , *LACTOBACILLUS acidophilus , *FIRST trimester of pregnancy , *PROBABILITY theory , *RESEARCH funding , *RNA , *CASE-control method , *GARDNERELLA , *GRAM-negative aerobic bacteria - Abstract
Objectives: To explore differences in the vaginal microbiome between preterm and term deliveries.Design: Nested case-control study in 3D cohort (design, develop, discover).Setting: Quebec, Canada.Sample: Ninety-four women with spontaneous preterm birth as cases [17 early (<34 weeks) and 77 late (34-36 weeks) preterm birth] and 356 women as controls with term delivery (≥37 weeks).Methods: To assess the vaginal microbiome by sequencing the V4 region of the 16S ribosomal RNA (rRNA) gene in swabs self-collected during early pregnancy.Main Outcome Measures: Comparison of relative abundance of bacterial operational taxonomic units and oligotypes and identifying vaginal community state types (CSTs) in early or late spontaneous preterm and term deliveries.Results: Lactobacillus gasseri/ Lactobacillus johnsonii (coefficient -5.36, 95% CI -8.07 to -2.65), Lactobacillus crispatus (99%)/ Lactobacillus acidophilus (99%) (-4.58, 95% CI -6.20 to -2.96), Lactobacillus iners (99%)/ Ralstonia solanacearum (99%) (-3.98, 95% CI -6.48 to -1.47) and Bifidobacterium longum/ Bifidobacterium breve (-8.84, 95% CI -12.96 to -4.73) were associated with decreased risk of early but not late preterm birth. Six vaginal CSTs were identified: four dominated by Lactobacillus; one with presence of bacterial vaginosis-associated bacteria (Gardnerella vaginalis, Atopobium vaginae and Veillonellaceae bacterium) (CST IV); and one with nondominance of Lactobacillus (CST VI). CST IV was associated with increased risk of early (4.22, 95% CI 1.24-24.85) but not late (1.63, 95% CI 0.68-5.04) preterm birth, compared with CST VI.Conclusions: Lactobacillus gasseri/L. johnsonii, L. crispatus/L. acidophilus, L. iners/R. solanacearum and B. longum/B. breve may be associated with decreased risk of early preterm birth. A bacterial vaginosis-related vaginal CST versus a CST nondominated by Lactobacillus may be associated with increased risk of early preterm birth.Tweetable Abstract: Largest study of its kind finds certain species of vaginal Lactobacillus + Bifidobacterium may relate to lower risk of preterm birth. [ABSTRACT FROM AUTHOR]- Published
- 2019
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