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Disc displacement (DD) appears in the majority of temporomandibular disorder (TMD) patients. The correlation between craniofacial morphology and different disc positions has been underlined, while the craniofacial morphological differences based on sex and sagittal skeletal pattern stratification have been insufficiently studied. In this study, 304 patients with TMD complaints were included and classified into normal position, disc displacement with reduction (DDwR) and disc displacement without reduction (DDwoR) groups according to magnetic resonance imaging. A total of 24 cephalometric measurements, covering the cranial base, vertical relationship, sagittal relationship, mandible position and morphology, and dental relationship, were assessed using lateral cephalograms. A stratified analysis was performed based on the sex and sagittal skeletal pattern. Overall, DD patients had distinctive craniofacial morphological features. The posterior cranial base length and mandibular arc angle were statistically different only in females, while the Y-axis angle, occlusal plane angle and sella nasion point A angle (SNA) might be unique features in males. Skeletal class II had the most statistically different measurements compared to the others. Differences in the Frankfort mandibular incisor angle (FMIA) and saddle angle were especially displayed in skeletal class III patients. The sex and skeletal sagittal pattern could affect the morphological differences in TMD patients with different disc positions. [ABSTRACT FROM AUTHOR]

Reticular chemistry enables the precise prediction for metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) by opening up an infinite space of the chemical compositions, structures, and material properties. Leveraging the reticular design, MOFs and COFs (MOFs/COFs)-based hybrids have made significant advances in both fundamental properties and sensor applications. MOFs/COFs-based hybrids feature intrinsic fascinating properties including extremely large specific surface area, size and shape tunable nanoporosity, and unique surface chemistry, and therefore they can be competitive candidate for the facile production of various nanostructures and further exploration of unique merits to address the limitations of sensor applications. Herein, we provide a comprehensive overview in the synthesis of MOFs/COFs-based hybrids in sensing fields and particularly highlight their roles for agricultural sensors. In the end, we briefly discussed the challenges and perspectives of MOFs/COFs-based hybrids in novel agricultural sensing. • Synthesis strategies of MOFs/COFs-based hybrids for sensing analysis are concluded. • The roles of MOFs/COFs-based hybrids in sensors for agricultural applications are detailed discussed. • The potential of MOFs/COFs-based hybrids to accelerate the development of smart agriculture is analyzed. [ABSTRACT FROM AUTHOR]

Abstract The highly catalytic Ca-doped carbon dots (CD Ca) were prepared by microwave procedure, that exhibit strong catalytic effect on HAuCl 4 -glucose (GLC) reaction to form gold nanoparticles (AuNPs) with high SERS activity, using Victoria blue B (VBB) as a molecular probe. The SERS intensity at 1615 cm−1 increased linearly with CD Ca increasing, due to formation of more AuNPs nanosol substrate as indicator. When thrombin aptamer (Apt) was added in this system, Apt adsorbed on the CD Ca surface to inhibit theirs catalytic activity, and the SERS intensity decreased. However, when thrombin (TB) was present, it can bind to Apt to form stable G-duplex of Apt-TB and free CD Ca catalyst in the system, and the SERS signal increased linearly. Thus a free-label Apt-SERS quantitative analysis method was developed for ultratrace TB, with a linear range of 0.0058–0.115 nmol/L and a detection limit of 0.0018 nmol/L TB. Highlights • The highly catalytic Ca-doped carbon dots (CDCa) were prepared by microwave procedure. • CD Ca exhibits strong catalysis of the SERS active gold nanoparticle reaction. • The catalytic reaction was used to amplify SERS signal. • A free-label Apt-SERS quantitative analysis method was developed for ultratrace TB. [ABSTRACT FROM AUTHOR]

Highlights: The materials, fabrication methods, implantation technologies, and applications of implantable electrochemical microsensors for animals were summarized. The implantable electrochemical microsensors for monitoring diseases and exploring disease mechanisms were discussed. The current status, ongoing challenges, and future development prospects of implantable electrochemical microsensors in monitoring animal physiological information were highlighted. In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human diseases. Currently, implantable electrochemical microsensors have emerged as a prominent area of research. These microsensors not only fulfill the technical requirements for monitoring animal physiological information but also offer an ideal platform for integration. They have been extensively studied for their ability to monitor animal physiological information in a minimally invasive manner, characterized by their bloodless, painless features, and exceptional performance. The development of implantable electrochemical microsensors for in vivo monitoring of animal physiological information has witnessed significant scientific and technological advancements through dedicated efforts. This review commenced with a comprehensive discussion of the construction of microsensors, including the materials utilized and the methods employed for fabrication. Following this, we proceeded to explore the various implantation technologies employed for electrochemical microsensors. In addition, a comprehensive overview was provided of the various applications of implantable electrochemical microsensors, specifically in the monitoring of diseases and the investigation of disease mechanisms. Lastly, a concise conclusion was conducted on the recent advancements and significant obstacles pertaining to the practical implementation of implantable electrochemical microsensors. [ABSTRACT FROM AUTHOR]

Background Objective Materials and Methods Results Conclusions Temporomandibular joint disorders (TMDs) are common in young adults, and the link between chronotype profile and TMDs is unclear.This study examined TMD prevalence and chronotype distribution and explored the relationship between chronotype and TMDs in young adults.A total of 663 students from Sichuan University completed questionnaires. Chronotype profiles were assessed using the Morningness‐Eveningness Questionnaire, and TMDs were screened using the Fonseca Memory Index. To validate the findings, 68 TMD patients and 136 controls were enrolled.The prevalence of TMDs was 69.7%, with significant differences among chronotype profiles. The intermediate profile was the most common chronotype. Eveningness profile was associated with higher TMDs prevalence and severity. Muscle pain and side movement difficulty scores were higher in eveningness and intermediate profiles. Female gender (OR 2.345; 95% CI 1.668–3.297) was a TMD risk factor, while morningness profile (OR 0.537; 95% CI 0.297–0.970) was protective. Validation with TMD patients and controls supported these findings, showing higher eveningness profile prevalence in the TMD groups.TMDs have a high prevalence in college students, chronotype profiles shown to be associated with TMDs. Morningness is the protection factor in TMDs and PT, eveningness is a risk factor for IT. [ABSTRACT FROM AUTHOR]

Objective: The association between jaw function and income in patients with temporomandibular disorders (TMDs) remain unclear. The aim of this study was to explore this association and its relationship with anxiety and depression. Subjects and Methods: A total of 451 TMD patients, including 361 males and 90 females, participated in this study. The sociodemographic information of patients and their questionnaires including the Generalised Anxiety Disorder 7‐item (GAD‐7), Patient Health Questionnaire 9‐item (PHQ‐9), and Jaw Functional Limitation Scale‐8 (JFLS‐8) were collected. Patients were divided into the high‐income and low‐income groups based on a household per capita income of 6000 RMB per month. Multiple regression and mediation analysis were used to explore the association between variables. The bootstrap method was applied to estimate confidence intervals (CIs). Results: Higher JFLS‐8 scores were significantly correlated with higher GAD‐7 scores (r = 0.361, p <.001), PHQ‐9 scores (r = 0.339, p <.001). Females and patients with low income had statistically higher JFLS‐8 scores (p <.01, p <.001). Mediation analysis with 10 000 bootstrap simulations revealed a significant direct association between JFLS‐8 scores and income (−2.920, 95% CI [−4.757, −1.044], p =.002). A significant indirect association of JFLS‐8 scores with income via GAD‐7 scores and PHQ‐9 scores was also observed (−0.889, 95% CI [−1.728, −0.164], p =.025), accounting for 23.3% of the total association. Conclusions: Low income is associated with impaired jaw function via anxiety and depression in patients with TMD. Clinicians may need to pay more attention to the psychological status of low‐income TMD patients in clinical practice. [ABSTRACT FROM AUTHOR]