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Omphalocele is a congenital malformation whose treatment is medico-surgical. It is often associated with other malformations that may be lifethreatening. The purpose of the study was to determine the epidemiological, diagnostic and therapeutic aspects of omphaloceles at Libreville university teaching hospital. our study was a singlecenter descriptive transversal study from January 1st, 2015 to December 31st, 2018, that is 4 years. Were included in the study, newborns with omphalocele hospitalized in the neonatology department of the University Hospital of Libreville. The parameters studied were epidemiological, prenatal history, diagnostic and therapeutic. We enrolled 16 newborns. The mean time to admission was 1.3 days ranging from 0-13 days. Mean gestational age was 38 weeks of amenorrhea. The sex ratio was 0.7 with a female predominance (9/7). The average birth weight was 2847 g (1960g - 4100g). No mothers had a history of teratogenic drug use and 10 were multiparous. An antenatal diagnosis was made in 3 cases. The omphalocele was type II in 11 patients. The liver was present in the bag in 8 patients. Six patients had associated malformations. Non operative methods aimed at progressive epithelisation were performed in 8 patients. Surgical treatment was performed in 8 patients, 7 of whom underwent primary closure. The postoperative course was simple in 2/8 patients. We recorded 6 deaths. Improving of the prognosis of omphalocele requires more antenatal diagnosis and a neonatal intensive care unit. [ABSTRACT FROM AUTHOR]

Cotton is one of the most significant commodities in the whole world, so the protection of this kind of crop against pest insect infestations is essential. This work aims to evaluate the insecticidal potential of the essential oil of the leaves of Persea venosa Nees & Mart. and its nanoemulsion against the cotton stainer bug. Fresh leaves of P. venosa were submitted to hydrodistillation and analyzed by gas chromatography (GC) coupled to a mass spectrometer (MS). The plant species presented the substance β-caryophyllene, Caryophyllene oxide, α-humulene, and α-copaene as the major compounds, comprising 43.78 %, 8.92 %, 8.27 % and 5.90 % of the essential oil, respectively. The nanoemulsion was obtained by low energy input, using the phase inversion method, generating a nanoemulsion with a particle size of 68.41 nm. The insecticidal assays were conducted to evaluate the lethality and sub-lethal damages at the cotton-stainer-bug. The essential oil and nanoemulsion presented LD 50 of 24.45 μg/µL and 28.73 μg/µL respectively. Pure oil and the dilution at a concentration of 450 μg/µL caused 100 % mortality of the insects on the first day. An assay was performed with β-caryophyllene, which also showed 100 % mortality on the first day of treatment, indicating that the major substance could be responsible for insect mortality. The nanoemulsion showed 55 % of mortality after 20 days. Delays in insect development were observed in all samples tested. The essential oil showed selectivity to D. peruvianus by not causing significant harm to Apis mellifera and Partamona helleri. This research shows promising feasibility results for producing a nanoemulsified essential oil with selective insecticidal activity to control a pest of agricultural importance. [Display omitted] • First demonstration of Persea venosa essential oil insecticidal activity. • The insecticidal activity was shown with both essential oil and nanoemulsion. • A bioproduct was prepared without organic solvent methodology. • Non-target pollinator bees did not suffer any significant harm. [ABSTRACT FROM AUTHOR]