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This paper describes the results of a study undertaken at the Iowa State University Libraries to evaluate the database tape products of three companies. The ultimate purpose of the study was to choose and locally mount the database tapes of one general periodical literature index on a NOTIS-based OPAC. The databases were compared and contrasted according to scope, duplication, gaps, depth of indexing, timeliness, format, and subject coverage as well as other criteria. [ABSTRACT FROM PUBLISHER]

Evaluates the database products of the Information Access Co. (IAC), the University Microfilm International (UMI) and H.W. Wilson. Development of benchmarks by the Iowa State University; Comparison of databases according to different criteria; Strengths and weaknesses of each company's products.

Proposes a model methodology for reviewing academic branch libraries which may be utilized by any institution undertaking such a process. Circumstances requiring review of branch libraries; Association of College & Research Libraries guidelines and standards and their applicability; Literature of academic branch libraries; Presentation of model methodology.

KLF1 (formerly known as EKLF) regulates the development of erythroid cells from bi-potent progenitor cells via the transcriptional activation of a diverse set of genes. Mice lacking Klf1 die in utero prior to E15 from severe anemia due to the inadequate expression of genes controlling hemoglobin production, cell membrane and cytoskeletal integrity, and the cell cycle. We have recently described the full repertoire of KLF1 binding sites in vivo by performing KLF1 ChIP-seq in primary erythroid tissue (E14.5 fetal liver). Here we describe the KLF1-dependent erythroid transcriptome by comparing mRNA-seq from Klf1+/+ and Klf1-/- erythroid tissue. This has revealed novel target genes not previously obtainable by traditional microarray technology, and provided novel insights into the function of KLF1 as a transcriptional activator. We define a cisregulatory module bound by KLF1, GATA1, TAL1, and EP300 that coordinates a core set of erythroid genes. We also describe a novel set of erythroid-specific promoters that drive high-level expression of otherwise ubiquitously expressed genes in erythroid cells. Our study has identified two novel lncRNAs that are dynamically expressed during erythroid differentiation, and discovered a role for KLF1 in directing apoptotic gene expression to drive the terminal stages of erythroid maturation. [ABSTRACT FROM AUTHOR]