Search

In this study, accelerometric data from seven Japanese buildings under long-term monitoring were analysed to explore the variability of the buildings' co-seismic response over time and its within- and between-building components, using co-seismic capacity curves developed in acceleration-displacement-response-spectrum format. The data include the 2011 Tohoku Mw9.1 earthquake, which caused building damage of different levels of severity, and the time-varying actual capacity curves were analysed considering earthquakes before and after 2011. Result showed that the initial slope of the capacity curves reflects the amount of damage. The between-building and within-building components of the variability are discussed by comparing a single building and several buildings in the same class for several earthquakes. Finally, the epistemic uncertainty of seismic risk assessment studies is discussed in relation to the selection of a generic capacity model for all buildings in a single class. [ABSTRACT FROM AUTHOR]

Peg3 (Paternally expressed gene 3) is an imprinted gene encoding a DNA-binding protein that is a well-known transcriptional repressor. Previous studies have shown that the mutant phenotypes of Peg3 are associated with the over-expression of genes involved in lipid metabolism. In the current study, we investigated four potential downstream genes of Peg3, which were identified through ChIP-seq data: Acly, Fasn, Idh1, and Hmgcr. In vivo binding of PEG3 to the promoter region of these key genes involved in lipogenesis was subsequently confirmed through individual ChIP experiments. We observed the opposite response of Acly expression levels against the variable gene dosages of Peg3, involving 0x, 1x, and 2x Peg3. This suggests the transcriptional repressor role of Peg3 in the expression levels of Acly. Another set of analyses showed a sex-biased response in the expression levels of Acly, Fasn, and Idh1 against 0x Peg3 with higher levels in female and lower levels in male mammary glands. These results overall highlight that Peg3 may be involved in regulating the expression levels of several key genes in adipogenesis. [ABSTRACT FROM AUTHOR]

Sepsis is a global health burden that needs intensive medical care. Thrombocytopenia in sepsis is well known to increase morbidity as well as mortality. Several studies have been performed both in animal models and in humans to understand the mechanism by which sepsis causes thrombocytopenia. Recent studies have shown that inhibiting thrombocytopenia improves outcomes in sepsis patients. Understanding these mechanisms to identify targets in use of newer treatment modalities besides using resuscitation measures, antibiotics and removal of thrombocytopenia inducing agent could potentially help us improve outcomes in sepsis. [ABSTRACT FROM AUTHOR]

Pancreas divisum is the most common congenital malformation of the pancreas. Sometimes it is considered an etiology when patients present with recurrent episodes of pancreatitis. Endoscopic retrograde pancreatography (ERP) with selective cannulation of the minor papilla with sphincterotomy and stent placement are performed in these patients. Proximal migration of pancreatic stents in pancreas divisum is rare and challenging to manage. We describe a case of proximal migration of a pancreatic stent in a patient with pancreas divisum and perform a review of literature. [ABSTRACT FROM AUTHOR]

Circular RNA is a newly discovered class of non-coding RNA generated through the back-splicing of linear pre-mRNA. In the current study, we characterized two circular RNAs that had been identified through NGS-based 5’RACE experiments. According to the results, the Peg3 locus contains a 214-nucleotide-long circular RNA, circPeg3, that is detected in low abundance from the neonatal brain, lung and ovary. In contrast, the Igf2r locus contains a group of highly abundant circular RNAs, circIgf2r, showing multiple forms with various exon combinations. In both cases, the expression patterns of circPeg3 and circIgf2r among individual tissues are quite different from their linear mRNA counterparts. This suggests potential unique roles played by the identified circular RNAs. Overall, this study reports the identification of novel circular RNAs specific to mammalian imprinted loci, suggesting that circular RNAs are likely involved in the function and regulation of imprinted genes. [ABSTRACT FROM AUTHOR]

Lenvatinib, an oral multikinase inhibitor, was approved by the US Food and Drug Administration in February 2015. In a pivotal phase III study of 392 patients with progressive radioiodine-refractory thyroid cancer, the overall response rate of patients receiving lenvatinib was 64.8%, with complete response in four patients. The median progression-free survival was 18.3 months in the lenvatinib arm versus 3.6 months in patients receiving placebo. Median overall survival was not reached in either arm. Lenvatinib is a promising new treatment for patients with radioiodine (iodine-131)-refractory differentiated thyroid cancer. [ABSTRACT FROM AUTHOR]

Cocaine is one of the most commonly abused drugs in the United States. Ingestion of cocaine may result in a wide array of disease processes due to its stimulant properties, contaminants, or to downstream effects, such as myocardial infarction, stroke, or cardiac arrest. Pulmonary complaints are common in patients seeking treatment for cocaine-associated medical problems and include acute eosinophilic pneumonia, pneumothorax, pneumomediastium, diffuse alveolar hemorrhage (DAH), pulmonary hypertension and granulomatosis. We present a case of DAH due to cocaine abuse and rapid resolution with mechanical ventilation and supportive care. [ABSTRACT FROM AUTHOR]

In this paper, a number of spectral and ordinary ground motion intensity measures (IMs) are tested for use in structural performance assessment. Real strong motion values recorded at the top and the bottom of US, Japanese and Romanian buildings are analyzed in order to identify the source of uncertainties in the prediction of engineering demand parameters (i.e. structural drift) for given IMs (i.e. σ EDP|IM). The efficiency and sufficiency of each IM from a large set of building and earthquake motion data are tested for different criteria characterizing the seismic source (magnitude and source-to-site distance), and considering several building classes and a specific single-building analysis including aging due to cumulative earthquake damage over time. The spectral values at co-seismic resonance frequencies was found to be the most efficient IMs for the range of buildings and earthquakes investigated, particularly for velocity with a reduction of approximately 50% of the σ EDP|IM value. Conversely, most IMs are relatively insufficient. • Integrating real structural state lowers building response prediction uncertainties. • The spectral values at co-seismic resonance frequencies are the most efficient IMs. • Building frequency change during earthquakes. • A simple empirical building damage prediction equation is developed. [ABSTRACT FROM AUTHOR]

B INTRODUCTION: b Ethylene glycol metabolites Glycolic and Glyoxylic Acids are structurally similar to lactate and can cause artificial elevation of lactate concentration. B DISCUSSION: b Glycolic acid and glyoxylic acid, metabolites of ethylene glycol, can both cause artificial elevation of lactate. ABG analyzer using L-lactate oxidase may have cross reaction with ethylene glycol metabolites while analyzers using lactate dehydrogenase such as standard chemistry analyzers are free of these interference.(1) By measuring a "lactate gap" with lactate values from two different analyzers, only one of which is sensitive to ethylene glycol metabolites, we can diagnose ethylene glycol poisoning before we get ethylene glycol level from laboratory testing which take some time.(2). [Extracted from the article]

Over the last two decades, seismic ground motion prediction has been significantly improved thanks to the development of shared, open, worldwide databases (waveform and parametric values). Unlike seismic ground motion, earthquake data recorded in buildings are rarely shared. However, their contribution could be essential for evaluating the performance of structures. Increasing interest in deploying instrumentation in buildings gives hope for new observations, leading to better understanding of behavior. This manuscript presents a flat-file containing information on earthquake responses of instrumented buildings. Herein, we present the structure of the NDE1.0 flat-file containing structural response parameters (i.e. drift ratio, peak top values of acceleration, velocity and displacement, pre- and co-seismic fundamental frequencies) computed for several intensity measures characterizing ground motion (i.e. peak ground values of acceleration, velocity and displacement, spectral values, Arias intensity, strong motion duration, cumulative absolute velocity, destructive potential). The data are from real earthquake recordings collected in buildings over the years. Some building, site and earthquake characteristics are also included (i.e. structural design, shear wave velocity, magnitude, epicentral distance, etc.). This 1.0 version contains 8520 strong motion recordings that correspond to 118 buildings and 2737 events, providing useful information for analyses related to seismic hazard, variability of building responses, structural health monitoring, nonlinear studies, damage prediction, etc. [ABSTRACT FROM AUTHOR]

In the current study, we characterized the expression and histone modification profiles of the alternative promoters found within imprinted Igf2r, Mest, Zac1, Peg3, Snrpn and non-imprinted Myc loci. In terms of expression pattern, the alternative promoters are highly tissue-specific, which is in a stark contrast to the ubiquitous expression of the corresponding main promoters. The alternative promoters are associated with the histone modification mark H3K4me1, but not with H3K4me3, which is frequently associated with the main promoters. Phylogenetic analyses also indicated that the majority of the alternative promoters are unique to the mammalian lineage, further suggesting the recent formation of these promoters during mammalian evolution. Overall, this study suggests that the alternative promoters of imprinted loci may have been derived from enhancers in recent evolutionary times and co-evolved with the genomic imprinting mechanism. [ABSTRACT FROM AUTHOR]

Adrenal cortical carcinoma is a rare and aggressive cancer with poor prognosis. Cases usually present with signs and symptoms of excessive hormone production. Hyperglycemia and Cushing syndrome are common, but tumor-associated hypoglycemia due to paraneoplastic secretion of insulin-like growth factor-2 (termed Anderson's syndrome) is uncommon. Given the rarity of adrenal cortical carcinoma, diagnosis and management of associated complications is challenging. In this study, we present a case of metastatic adrenal cortical carcinoma with a myriad of hormonal abnormalities. We will also briefly review literature regarding genetic association, pathophysiology, treatment options, and prognosis. [ABSTRACT FROM AUTHOR]

The parental allele specificity of mammalian imprinted genes has been evolutionarily well conserved, although its functional constraints and associated mechanisms are not fully understood. In the current study, we generated a mouse mutant with switched active alleles driving the switch from paternal-to-maternal expression for Peg3 and the maternal-to-paternal expression for Zim1. The expression levels of Peg3 and Zim1, but not the spatial expression patterns, within the brain showed clear differences between wild type and mutant animals. We identified putative enhancers localized upstream of Peg3 that displayed allele-biased DNA methylation, and that also participate in allele-biased chromosomal conformations with regional promoters. Most importantly, these data suggest for the first time that long-distance enhancers may contribute to allelic expression within imprinted domains through allele-biased interactions with regional promoters. [ABSTRACT FROM AUTHOR]

Background: Previous reports have been inconsistent in generating a consensus for optimal treatment strategy for patients with percutaneous coronary intervention (PCI) who also require oral anticoagulation (OAC). We conducted a traditional and network meta-analysis to evaluate the safety and efficacy of anti-thrombotic regimens in this subset of patients.Methods: 30 articles were recovered through preferred reporting items for systematic reviews and meta-analyses (PRISMA) using MEDLINE, EMBASE and Cochrane Central Register of Controlled Clinical Trials (CENTRAL) from inception to December 2016.Results: Dual antiplatelet therapy (DAPT) was found to be the safest treatment modality when compared to triple therapy (TT) or combination of OAC and single antiplatelet agent (OAC+SAP) [Major bleeding: (DAPT vs OAC+SAP: odds ratio (OR), 0.53; 95% credible interval (CrI), 0.30-0.91) (DAPT vs TT: OR, 0.45; 95% CrI, 0.31-0.64)]. There were no significant differences in major adverse cardiovascular events (MACE), myocardial infarction (MI), cardiovascular (CV) or total survival, stent thrombosis or target vessel revascularization (TVR) amongst the three treatment arms. TT was ranked superior for stroke reduction (SUCRA, 69%) followed by OAC+SAP and DAPT. When traditional analysis was adjusted for randomized data, OAC+SAP was equivalent to TT with regards to stroke (OR, 0.74; 95% confidence interval (CI), 0.38-1.46; p=0.39) and showed significant reduction in MACE and total mortality.Conclusion: DAPT was found to be the safest and equally effective regimen when compared to TT and OAC+SAP. However this strategy bears considerable risk to patients with high thromboembolic risk. This issue can be encountered by using OAC+SAP as an alternative of TT in patients with intermediate to high stroke risk and intermediate to high bleeding propensity. [ABSTRACT FROM AUTHOR]