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The relationship between suicide attempts and lipid profiles in patients with major depressive disorder (MDD) remains uncertain. The purpose of this study was to investigate sex differences in the relationship between suicide attempts and plasma lipid profiles in a large sample of first-episode and drug naive (FEDN) MDD patients. We recruited 1718 FEDN MDD patients and gathered demographic, clinical, and blood lipid data. The Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale and the Positive and Negative Syndrome Scale were used to assess the symptoms of patients. There was no significant difference in the prevalence of suicide attempts between male and female MDD patients. The suicide attempt group had higher levels of depression, anxiety, psychotic symptoms, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), but lower levels of high-density lipoprotein cholesterol (HDL-C) levels than the non-suicide attempt group. Binary logistic regression showed that TC levels were significantly correlated with suicidal attempts in both male and female patients. Correlation analysis revealed that the levels of TC, HDL-C and LDL-C were significantly associated with the number of suicide attempts in both male and female patients. Further multiple linear regression revealed that TC levels were significantly associated with the number of suicide attempts in male patients only. Lipid biomarkers, particularly high TC levels, are associated with suicide attempts in both male and female MDD patients. However, there is gender difference in association between lipid biomarkers, especially TC levels, and the number of suicide attempts in MDD patients. • There was no gender difference in the prevalence of suicide attempts in MDD patients. • Suicide attempters had higher depression severity, anxiety, and psychotic symptoms. • 3.Suicidal attempters showed higher TC, LDL-C, but lower HDL-C levels. • TC levels were significantly associated with suicide attempts in both male and female patients. • Only male patients' s TC levels associated with the number of suicide attempts. [ABSTRACT FROM AUTHOR]

Manganese-based Metal-organic Frameworks (Mn-MOFs) represents a unique sub-class of MOFs with low toxicity, oxidative ability, and biocompatibility, which plays vital role in the application of this class of MOFs in medical field. Mn-MOFs show great potential in biomedical applications, and has been extensively studied as compared to other MOFs in transition metal series. They are important in medical applications because Mn(II) possess large electron spin number and longer electron relaxation time. They display fast water exchange rate and could be employed as a potential MRI contrast agent because of their strong targeting ability. Manganese complexes with different ligands also display prospective applications in area such as carrier for drug targeting in anti-tumor and antimicrobial therapy. In the review presented herewith, the application of Mn-based complexes and Mn-MOFs have been emphasized in the area such as imaging viz. MRI, multimodal imaging, antitumor activities such as chemodynamic therapy, photodynamic therapy, sonodynamic therapy and antimicrobial applications. Also, how rational designing and syntheses of targeted Mn-based complexes and Mn-MOFs can engender desired applications. [Display omitted] • Mn-MOFs are divided into three categories based on their multidisciplinary applications. • Mn-based materials employed as a potential MRI agent due to their strong targeting ability. • Representative examples of these characteristics and mechanisms have been illustrated. • These applications of CDT, SDT and PDT therapy for Mn-MOFs have discussed. [ABSTRACT FROM AUTHOR]

Functional deficits including cognitive impairment and social dysfunction are the core symptoms of schizophrenia (SCZ), and sensory gating (SG) deficits may be involved in the pathological mechanism of functional deficits in SCZ. This study was to investigate the relationship between defective P50 inhibition and functional deficits in first-episode drug naïve (FEDN) SCZ patients. A total of 95 FEDN SCZ patients and 53 healthy controls (HC) were recruited. The Chinese version of UCSD Performance-Based Skills (UPSA), MATRICS Consensus Cognitive Battery (MCCB), and EEG system were used to assess the social function, cognitive performance, and P50 inhibition, respectively. The MCCB total score and eight domain scores were significantly lower in patients with FEDN SCZ than those in HC (all p < 0.05). The UPSA total score and financial skills scores were also significantly lower in SCZ patients than that in the HC (all p < 0.05). Compared with HC, patients with FEDF SCZ had a higher P50 ratio (all p < 0.05). There was no correlation between P50 components and MCCB scores in patients with FEDF SCZ. However, there was only a correlation between the P50 ratio and UPSA financial skills, communication skills, or total score in patients (all p < 0.05). Defective P50 inhibition in FEDN SCZ patients may be associated with social dysfunction but not cognitive impairment, suggesting that the social dysfunction and cognitive impairment of patients with FEDN SCZ may have different pathogenic mechanisms. [ABSTRACT FROM AUTHOR]

Once virtual reality technology (Virtual Reality, VR) came out, it has received a lot of attention; in recent years, it has been widely used in the study of psychology. Because it can improve the ecological validity of experimental research, the level of conditional control, reproducibility, and avoid the dangers of field operations, it has been introduced into the field of psychology by many researchers. Compared with traditional sports psychology research methods, virtual reality technology has the characteristics of multiperception, immersion, interaction, and imagination to get a better, more realistic feel and increase people's interest in sports. Taking the application of virtual reality technology in table tennis teaching in colleges and universities as an example, this study aims to review the application of virtual reality technology in sports psychology; summarize the theory, practice, and prospect of the application of virtual reality technology in sports psychology; and add new content to the research of sports psychology. It aims to review the principles, characteristics, and application of virtual reality technology in sports psychology; summarize the advantages and disadvantages of the application of virtual reality technology in sports and point out the problems that need to be paid attention to when using this method; explore the application of virtual reality technology in sports psychology; and add new content to the research of sports psychology. [ABSTRACT FROM AUTHOR]

The Data Interpolation Empirical Orthogonal Functions (DINEOF) method is accurate in filling missing remote sensing datasets. This study used the Data-Interpolating Convolutional Auto-Encoder (DINCAE) method to reconstruct chlorophyll-a concentration (Chl-a) data from the Bohai and Yellow seas and compare it with DINEOF. The reconstruction power of the two methods was evaluated using cross-validation and in situ data, and the accuracy of both data validated by DINCAE was higher than that of DINEOF. The reconstruction results of the two methods were analysed from two perspectives: time and space scale. The reconstruction errors of DINCAE were lower than those of DINEOF at different temporal scales, and the temporal sensitivity of DINEOF was greater than that of DINCAE. DINCAE outperforms DINEOF in terms of controlling the small-scale features and Chl-a values. In terms of efficiency, DINCAE is five times faster than DINEOF for similar reconstruction conditions. [ABSTRACT FROM AUTHOR]

The vertical mixing parameterization scheme, by providing the effects of some explicitly missed physical processes and more importantly closing the energy budgets, is a critical model component and therefore imposes significant impacts on model performance. The Yellow Sea Cold Water Mass (YSCWM), as the most striking and unique phenomenon in the Yellow Sea during summer, is dramatically affected by vertical mixing process during its each stage and therefore seriously sensitive to the proper choice of parameterization scheme. In this paper, a hindcast of YSCWM in winter of 2006 was implemented by using the Regional Ocean Modeling System (ROMS). Three popular parameterization schemes, including the level 2.5 Mellor-Yamada closure (M-Y 2.5), Generic Length Scale closure (GLS) and K-Profile Parameterization (KPP), were tested and compared with each other by conducting a series of sensitivity model experiments. The influence of different parameterization schemes on modeling the YSCWM was then carefully examined and assessed based on these model experiments. Although reasonable thermal structure and its seasonal variation were well reproduced by all schemes, considerable differences could still be found among all experiments. A warmer and spatially smaller simulation of YSCWM, with very strong thermocline, appeared in M-Y 2.5 experiment, while a spatially larger YSCWM with shallow mixed layer was found in GLS and KPP schemes. Among all the experiments, the discrepancy, indicated by core temperature, appeared since spring, and grew gradually by the end of November. Additional experiments also confirmed that the increase of background diffusivity could effectively weaken the YSCWM, in either strength or coverage. Surface wave, another contributor in upper layer, was found responsible for the shrinkage of YSCWM coverage. The treatment of wave effect as an additional turbulence production term in prognostic equation was shown to be more superior to the strategy of directly increasing diffusivity for a coastal region. [ABSTRACT FROM AUTHOR]

[Display omitted] A new metal–organic framework of {[Zn 2 (HL) 2 (4,4′-bipy)]·3H 2 O} n (1) (H 3 L = 1, 3, 5-tris(4-carbonylphenyloxy)benzene, 4,4′-bipy = 4,4′-bipyridine), was hydrothermally prepared and full characterized. 1 possesses 3D 3-fold interpenetrated framework. 1 obtained effectively photocatalytic performance to the disintegration of dyes Rhodamine B (Rh B) and methylene blue (MB). Furthermore, MOF 1 was selected as a selective probe for antibiotics metronidazole (MDZ) having the low detection limit 1.16 ppm. The plausible mechanism displayed by 1 for the catalytic degradation toward Rh B was proposed using the trapping method and LC-MS studies. [ABSTRACT FROM AUTHOR]