Search

Objective: The influence of vaspin on vascular health had been investigated, yielding conflicting results. This study is intended to investigate the relation between vaspin and stroke severity and stroke outcome in a cohort Chinese patient with acute ischemic stroke (AIS). Methods: This was a prospective single-center observational study in Xinxiang, China. From 1 July 2017 to 30 November 2019, all patients with first-ever AIS were consecutively included. Serum levels of vaspin, stroke severity at (assessed by NIHSS score) admission and functional outcome (assessed by modified Rankin Scale (mRS)) at discharge were recorded. Multivariate analyses were assessed using logistic regression models. Results: Finally, 340 patients with AIS were included. The median age of those patients was 65 (interquartile range [IQR], 56–74) years and 61.8% were men. At admission, 88 patients (25.9%) experienced severe stroke (NIHSS>10) and serum levels of vaspin (median [IQR]: 0.72[0.48–0.90]ng/ml) in those patients were significantly lower than in those mild(0.92[0.70–1.19]ng/ml) and moderate stroke (0.93[0.63–1.21]ng/ml). At discharge, 113 patients (33.2%) experienced poor functional outcome (mRS >2) and vaspin serum levels in those patients were lower as compared with patients who experienced good outcome (0.71[0.45–0.98] vs. 0.91[0.71–1.19]ng/ml). In multivariate analyses, lower level of vaspin (< median) was associated with a 2.5-fold (odds ratio [OR] 2.46; 95% confidence interval [CI]: 1.75–4.45) increased risk for severe stroke and a 2.1-fold (2.03; 1.42–3.58) increased risk for poor outcome. Conclusion: In conclusion, reduced serum levels of vaspin at admission are significantly related to stroke severity and prognosis, which illustrates a predictive role of reduced vaspin in ischemic stroke. [ABSTRACT FROM AUTHOR]

Abstract: The phase transitions that take place in Sr1 + x Co0.8Fe0.2O3− δ (−0.2≤ x ≤0.1) oxides are reported here. Thermogravimetric analysis (TGA) showed that the oxides with −0.2≤ x ≤0 were prone to undergo oxygen-vacancy disorder–order phase transitions, while others with x =0.05, 0.1 had more stable crystal structures during oxygen-desorption processes in nitrogen. These results were further confirmed by high-temperature in-situ X-ray techniques. The changes in activation energies of three typical oxides, Sr1 + x Co0.8Fe0.2O3− δ (x =−0.2, 0, 0.1), used as oxygen-permeable membranes were investigated. The phase transitions in Sr1 + x Co0.8Fe0.2O3− δ (x =−0.2, 0) have also been detected in differential scanning calorimetry (DSC) profiles. [Copyright &y& Elsevier]