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Background Training support staff in dealing with challenging behaviour in clients with intellectual disabilities (ID) is needed. The goal of this study is to determine which elements need to be incorporated in a training on staff interactions with these clients, building upon a framework and an interpersonal model. As in functional analysis, this study tests the influence of client interpersonal behaviour, three types of staff reactions to challenging behaviour, two types of staff psychological resources and staff team climate on four styles of staff interpersonal behaviour. Method A total of 318 support staff members completed a questionnaire on staff interpersonal behaviour for 44 clients with ID and challenging behaviour, as well as seven questionnaires on client interpersonal behaviour, staff emotions, attributions, self-efficacy, self-reflection, coping styles and team climate. The influence of these seven factors on four staff interpersonal behaviours was examined using multilevel multiple regression analysis. Results Friendly-warm and dominant client interpersonal behaviour had a significant positive impact on friendly and assertive control staff behaviour, respectively. Also, there was a strong influence of staff negative and positive emotions, as well as their self-efficacy, on most of the staff interpersonal behaviours. Staff self-reflection, insight and avoidance-focused coping style had an impact on some staff interpersonal behaviours. Staff team climate only predicted higher support-seeking staff behaviour. Conclusions In conducting a functional analysis of staff interpersonal behaviour, the results of this study can be used both as a framework in staff-client interaction training and in clinical practice for treating challenging behaviour. The emphasis in training and practice should not only be on the bidirectional dynamics of control and affiliation between staff and clients, but also - in order of importance - on the impact of staff emotions, self-efficacy, self-reflection and insight, coping style, team climate and attributions on staff interpersonal behaviour. [ABSTRACT FROM AUTHOR]

Abstract: Given that sexually offensive behavior on the part of people with intellectual disabilities has been identified as a significant problem, we developed a risk assessment questionnaire, that takes not only various static and dynamic factors into account but also environmental risk variables. Psychologists and staff members completed this Risk Inventarization Scale on Sexually Offensive Behavior of Clients with Intellectual Disabilities for 56 intellectually disabled clients with sexually offensive behavior problems. The scale contains static client variables (rated using two- or five-point likert scales and open questions) and both dynamic client and environmental variables (rated using a five-point likert scale). Factor analyses of the dynamic client and environmental variables revealed three subscales: quality of supervision, offending behavior and emotional and social stability. Reliability analyses showed sufficient to good reliability for both the total scale (r =0.82) and the identified subscales (quality of guidance r =0.94; offending behavior r =0.75, and emotional and social stability r =0.58). Correlational analyses of the quality of guidance subscale showed high positive correlations with such static variables as values and norms, living conditions, and criminal offenses in early youth. Because both dynamic and environmental variables can be altered, the implications for treatment of the sexually offensive behavior of clients with intellectual disabilities are discussed further. [Copyright &y& Elsevier]

Poster: Clinical track: Lung PO-1025: Prognostic factors for PFS and OS in radically treated patients with oligometastatic NSCLC M. LeenderS, R. Robeers, L. Hendriks, J. Van Loon, G. Bootsma, R. Wanders, C. Pitz, B. Reymen, R. Houben, A. Van Baardwijk, K. Verhoeven, S. Peeters, D. De Ruysscher. [Extracted from the article]

Context. Space asteroseismology reveals that stellar structure and evolution models of intermediate- and high-mass stars are in need of improvement in terms of angular momentum and chemical element transport. Aims. We aim to probe the interior structure of a hot, massive star in the core-hydrogen-burning phase of its evolution. Methods. We analysed CoRoT space photometry, Gaia DR2 space astrometry, and high-resolution high signal-to-noise HERMES and HARPS time-series spectroscopy of the slowly rotating B2V star HD 170580. Results. From the time-series spectroscopy, we derive v sin i = 4 ± 2 km s−1, where the uncertainty results from the complex pulsational line-profile variability that has been so far ignored in the literature. We detect 42 frequencies with amplitudes above five times the local noise level. Amongst these we identify five rotationally split triplets and one quintuplet. Asteroseismic modelling based on CoRoT, Gaia DR2, and spectroscopic data leads to a star of M ∼ 8 M⊙ near core-hydrogen exhaustion and an extended overshoot zone. The detected low-order pressure-mode frequencies cannot be fit within the uncertainties of the CoRoT data by models without atomic diffusion. Irrespective of this limitation, the low-order gravity modes reveal HD 170580 to be a slow rotator with an average rotation period between 73 and 98 d and a hint of small differential rotation. Conclusions. Future Gaia DR3 data taking into account the multiplicity of the star, along with long-term TESS photometry would allow us to put better observational constraints on the asteroseismic models of this blue evolved massive star. Improved modelling with atomic diffusion, including radiative levitation, is needed to achieve compliance with the low helium surface abundance of the star. This poses immense computational challenges but is required to derive the interior rotation and mixing profiles of this star. [ABSTRACT FROM AUTHOR]

Human dendritic cells (DC) are highly professional antigen presenting cells for the priming of naive cytotoxic T cells. Gene transfer in DC would be a useful strategy to load DC with relevant de novo synthesized antigens for immunotherapeutical purposes. As a first step towards a DC-based gene therapy, we examined the efficiency of nonviral transfection in different types of cultured human dendritic cells with a humanized red-shifted green fluorescent protein reporter gene. Plasmid DNA transfection by electroporation or lipofection was used to transfect CD34+ progenitor cell-derived DC (PC-DC) and Langerhans’ cells (PC-LC), as well as monocyte-derived DC (Mo-DC). While lipofection was unsuccessful in all types of DC, we obtained high-efficiency gene transfer by electroporation in PC-LC (16%) and PC-DC (12%). In contrast, electroporation was strikingly less efficient in Mo-DC (2%). The potent allostimulatory capacity of DC was still retained in electroporated PC-DC and PC-LC. In conclusion, electroporation of antigen expressing plasmid DNA is an efficient tool for nonviral gene transfer in PC-DC and PC-LC, but not in Mo-DC and could be useful for the development of DC-based tumor immunotherapy. [ABSTRACT FROM AUTHOR]