1. Effectiveness of vaccines in preventing hospitalization due to COVID-19: A multicenter hospital-based case-control study, Germany, June 2021 to January 2022.
- Author
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Stoliaroff-Pepin, Anna, Peine, Caroline, Herath, Tim, Lachmann, Johannes, Perriat, Delphine, Dörre, Achim, Nitsche, Andreas, Michel, Janine, Grossegesse, Marica, Hofmann, Natalie, Rinner, Thomas, Kohl, Claudia, Brinkmann, Annika, Meyer, Tanja, Dorner, Brigitte G., Stern, Daniel, Treindl, Fridolin, Hein, Sascha, Werel, Laura, and Hildt, Eberhard
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VACCINE effectiveness , *CASE-control method , *COVID-19 , *HOSPITAL care , *MEDICAL records - Abstract
• This study assesses detailed first-hand data and therefore provides a very high data quality. • Detailed interviews, abstraction of medical records and laboratory analyses were combined to obtain comprehensive data sets. • More than half of the cases (58 %) were not vaccinated at all, compared to 11 % of the controls. • The vaccine effictiveness to prevent severe disease in the Delta wave was 89 % overall for two doses and 98 % for three doses. We included 852 patients in a prospectively recruiting multicenter matched case-control study in Germany to assess vaccine effectiveness (VE) in preventing COVID-19-associated hospitalization during the Delta-variant dominance. The two-dose VE was 89 % (95 % CI 84–93 %) overall, 79 % in patients with more than two comorbidities and 77 % in adults aged 60–75 years. A third dose increased the VE to more than 93 % in all patient-subgroups. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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