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Also, by inferring from prior mentioned studies on hospitalized pediatric COVID-19 patients, we can affirm that most of them had an underlying disease and those with pre-existing medical problems developed more severe and critical presentations; the fact that Centers for Disease Control and Prevention (CDC) ratifies (CDC, 2020). EXCLI Journal 2021;20:503-505 - ISSN 1611-2156 Received: February 12, 2021, accepted: February 23, 2021, published: February 26, 2021 503 Letter to the editor: HOW SHOULD THE HIGH-RISK CHILDREN GO BACK TO SCHOOL FOLLOWING SCHOOL REOPENING IN THE COVID-19 PANDEMIC?. [Extracted from the article]