1. Effects of a single glucocorticoid injection on propylene glycol-treated cows with clinical ketosis.
- Author
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van der Drift, Saskia G.A., Houweling, Martin, Bouman, Marina, Koets, Ad P., Tielens, Aloysius G.M., Nielen, Mirjam, and Jorritsma, Ruurd
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ACETONEMIA , *GLUCOCORTICOIDS , *PROPYLENE glycols , *ADIPOSE tissues , *BLOOD sugar , *INSULIN research , *MESSENGER RNA , *THERAPEUTICS , *CATTLE , *3-Hydroxybutyric acid - Abstract
This study investigated the metabolic effects of glucocorticoids when administered to propylene glycol-treated cows with clinical ketosis. Clinical ketosis was defined by depressed feed intake and milk production, and a maximal score for acetoacetate in urine. All cows received 250 mL oral propylene glycol twice daily for 3 days and were randomly assigned to a single intramuscular injection with sterile isotonic saline solution ( n = 14) or dexamethasone-21-isonicotinate ( n = 17). Metabolic blood variables were monitored for 6 days and adipose tissue variables for 3 days. β-Hydroxybutyrate (BHBA) concentrations in blood decreased in all cows during treatment, but were lower in glucocorticoid-treated cows. Cows treated with glucocorticoids had higher plasma glucose and insulin concentrations, whereas concentrations of non-esterified fatty acids, 3-methylhistidine and growth hormone were unaffected. mRNA expression of hormone-sensitive lipase, BHBA receptor and peroxisome proliferator-activated receptor type γ in adipose tissue was not affected. This shows that lipolytic effects do not appear to be important in ketotic cows when glucocorticoids are combined with PG. Plasma 3-methyl histidine concentrations were similar in both groups, suggesting that glucocorticoids did not increase muscle breakdown and that the greater rise in plasma glucose in glucocorticoid-treated cows may not be due to increased supply of glucogenic amino acids from muscle. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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