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Their high tunability of electronic and magnetic properties makes transition‐metal oxides (TMOs) highly intriguing for fundamental studies and promising for a wide range of applications. TMOs with strong ferrimagnetism provide new platforms for tailoring the anomalous Hall effect (AHE) beyond conventional concepts based on ferromagnets, and particularly TMOs with perpendicular magnetic anisotropy (PMA) are of prime importance for today's spintronics. This study reports on transport phenomena and magnetic characteristics of the ferrimagnetic TMO NiCo2O4 (NCO) exhibiting PMA. The entire electrical and magnetic properties of NCO films are strongly correlated with their conductivities governed by the cation valence states. The AHE exhibits an unusual sign reversal resulting from a competition between intrinsic and extrinsic mechanisms depending on the conductivity, which can be tuned by the synthesis conditions independent of the film thickness. Importantly, skew‐scattering is identified as an AHE contribution for the first time in the low‐conductivity regime. Application wise, the robust PMA without thickness limitation constitutes a major advantage compared to conventional PMA materials utilized in today's spintronics. The great potential for applications is exemplified by two proposed novel device designs consisting only of NCO films that open a new route for future spintronics, such as ferrimagnetic high‐density memories. [ABSTRACT FROM AUTHOR]

Abstract: Ethnopharmacological relevance: Tripterygium hypoglaucum (levl.) Hutch (Celastraceae) (THH) root is a traditional Chinese medicinal herb commonly used for treating autoimmune diseases and cancer. Alkaloid is one of the most bioactive components of THH extract. To evaluate the in vitro and in vivo antitumor properties of the total alkaloids of THH (THHta). Materials and methods: THHta was extracted in pilot-scale. HCT116 cells were chose to establish human colon cancer xenograft model. The in vitro anti-tumor activity of THHta was tested by Cell malignant transformation test, Soft agar colony formation assay and MTT assay. The in vivo anti-tumor effect of THHta was confirmed by xenograft mouse model. THHta-induced apoptosis was examined by flow cytometry. The levels of apoptosis-related proteins were investigated by Western blot. Results: TPA-induced cell transformation was significantly inhibited by THHta in JB6 Cl41 cells. THHta inhibits the growth of colon cancer cells in vitro in a significant dose-dependent manner. Compared to the control set, i.p. administration of THHta to xenograft mice significantly reduced both tumor weight and volume. Apoptosis induction of THHta was mediated by activation of caspase-3, PARP and inhibiting of Bcl-2, Bcl-xL and XIAP. Conclusion: THHta was effective in inhibiting tumor growth both in vitro and in vivo at less toxic concentrations by inducing apoptosis which suggested it could be developed as a potential anticancer agent. [ABSTRACT FROM AUTHOR]

Lingshuiols A and B, two new polyhydroxyl compounds with linear carbon-chains, were isolated from the cultured Chinese marine dinoflagellate Amphidinium sp. Their structures were elucidated by extensive analysis of 2D NMR spectral data. [Copyright &y& Elsevier]

A novel polyhydroxy compound with a linear carbon-chain, lingshuiol (1), had been isolated from the cultured marine dinoflagellate Amphidinium sp. Its structure was elucidated by extensive analysis of 2D NMR spectral data. Lingshuiol possessed a powerful cytotoxic activity against A-549 and HL-60 cells in vitro with the IC50 of 0.21 and 0.23 μM, respectively. [Copyright &y& Elsevier]

A high performance pulse energy detector is developed based on photoacoustic effect. Different from the detectors reported before which also utilized photoacoustic effect, our detector can measure the energy of each pulse output from a Q-switched laser and monitor the pulse energy fluctuation in real time owing to the signal processing circuit designed. By comparing with a commercial laser energy meter, our detector is proved to be of high sensitivity and accuracy. We test the detector under illumination of different pulse energy at varied wavelengths, and the results demonstrate that the detector has a broad spectral response and a dynamical energy range. Besides, the measurements of this detector will not be affected by the background light according to the principle of photoacoustic effect. [ABSTRACT FROM AUTHOR]

The article reports that the design and preparation of supramolecular macrocyclic architectures has attracted intense interest in the past. decade. Successful strategies have been developed for the construction of metal macrocyclic structures with triangular and square shapes, but molecular polygons of higher numbers of sides are thus far scarce; just a few cases are known, although a series of mesoscopic metallocycles without crystal structures has also been reported. In principle, different molecular polygons can be rationally constructed by proper selection of corners and linear components; however, it is still a challenge to control the formation of such supramolecular isomers in coordination polymers.

Tin disulfide (SnS2) is a promising candidate for electrosynthesis of CO2‐to‐formate while the low activity and selectivity remain a great challenge. Herein, we report the potentiostatic and pulsed potential CO2RR performance of SnS2 nanosheets (NSs) with tunable S‐vacancy and exposure of Sn‐atoms or S‐atoms prepared controllably by calcination of SnS2 at different temperatures under the H2/Ar atmosphere. The catalytic activity of S‐vacancy SnS2 (Vs‐SnS2) is improved 1.8 times, but it exhibits an exclusive hydrogen evolution with about 100 % FE under all potentials investigated in the static conditions. The theoretical calculations reveal that the adsorption of *H on the Vs‐SnS2 surface is energetically more favorable than the carbonaceous intermediates, resulting in active site coverage that hinders the carbon intermediates from being adsorbed. Fortunately, the main product can be switched from hydrogen to formate by applying pulsed potential electrolysis benefiting from in situ formed partially oxidized SnS2−x with the oxide phase selective to formate and the S‐vacancy to hydrogen. This work highlights not only the Vs‐SnS2 NSs lead to exclusively H2 formation, but also provides insights into the systematic design of highly selective CO2 reduction catalysts reconstructed by pulsed potential electrolysis. [ABSTRACT FROM AUTHOR]

Tin disulfide (SnS2) is a promising candidate for electrosynthesis of CO2‐to‐formate while the low activity and selectivity remain a great challenge. Herein, we report the potentiostatic and pulsed potential CO2RR performance of SnS2 nanosheets (NSs) with tunable S‐vacancy and exposure of Sn‐atoms or S‐atoms prepared controllably by calcination of SnS2 at different temperatures under the H2/Ar atmosphere. The catalytic activity of S‐vacancy SnS2 (Vs‐SnS2) is improved 1.8 times, but it exhibits an exclusive hydrogen evolution with about 100 % FE under all potentials investigated in the static conditions. The theoretical calculations reveal that the adsorption of *H on the Vs‐SnS2 surface is energetically more favorable than the carbonaceous intermediates, resulting in active site coverage that hinders the carbon intermediates from being adsorbed. Fortunately, the main product can be switched from hydrogen to formate by applying pulsed potential electrolysis benefiting from in situ formed partially oxidized SnS2−x with the oxide phase selective to formate and the S‐vacancy to hydrogen. This work highlights not only the Vs‐SnS2 NSs lead to exclusively H2 formation, but also provides insights into the systematic design of highly selective CO2 reduction catalysts reconstructed by pulsed potential electrolysis. [ABSTRACT FROM AUTHOR]

Creating new electron‐deficient unit is highly demanded to develop high‐performance polymer donors for non‐fullerene organic solar cells (OSCs). Herein, we reported a multifluorinated unit 4,5,6,7‐tetrafluoronaphtho[2,1‐b : 3,4‐b′]dithio‐phene (FNT) and its polymers PFNT‐F and PFNT‐Cl. The advantages of multifluorination: (1) it enables the polymers to exhibit low‐lying HOMO (≈−5.5 eV) and wide band gap (≈2.0 eV); (2) the short interactions (F⋅⋅⋅H, F⋅⋅⋅F) endow the polymers with properties of high film crystallinity and efficient hole transport; (3) well miscibility with NFAs that leads to a more well‐defined nanofibrous morphology and face‐on orientation in the blend films. Therefore, the PFNT‐F/Cl : N3 based OSCs exhibit impressive FF values of 0.80, and remarkable PCEs of 17.53 % and 18.10 %, which make them ranked the best donor materials in OSCs. This work offers new insights into the rational design of high‐performance polymers by multifluorination strategy. [ABSTRACT FROM AUTHOR]

Creating new electron‐deficient unit is highly demanded to develop high‐performance polymer donors for non‐fullerene organic solar cells (OSCs). Herein, we reported a multifluorinated unit 4,5,6,7‐tetrafluoronaphtho[2,1‐b : 3,4‐b′]dithio‐phene (FNT) and its polymers PFNT‐F and PFNT‐Cl. The advantages of multifluorination: (1) it enables the polymers to exhibit low‐lying HOMO (≈−5.5 eV) and wide band gap (≈2.0 eV); (2) the short interactions (F⋅⋅⋅H, F⋅⋅⋅F) endow the polymers with properties of high film crystallinity and efficient hole transport; (3) well miscibility with NFAs that leads to a more well‐defined nanofibrous morphology and face‐on orientation in the blend films. Therefore, the PFNT‐F/Cl : N3 based OSCs exhibit impressive FF values of 0.80, and remarkable PCEs of 17.53 % and 18.10 %, which make them ranked the best donor materials in OSCs. This work offers new insights into the rational design of high‐performance polymers by multifluorination strategy. [ABSTRACT FROM AUTHOR]

A family of three-periodic nets formed from intersecting helical ladders (double helices) is described. Tilings and ring sizes are analyzed. Removal of the rungs of the ladders results in periodic patterns of linked rings (three-periodic 'chain mail'). A related family of nets formed from triple helices leads similarly to interwoven threads. [ABSTRACT FROM AUTHOR]

Herein, the design and synthesis of an unprecedented cobaloxime-based zirconium metal–organic framework (Zr-TCPCo) with an she net is reported. This heterogeneous material as a photocatalyst exhibits excellent catalytic activity for aerobic oxidation of arylboronic acids to phenols. Recycling experiments demonstrate the stability and reusability of Zr-TCPCo as a robust catalyst. [ABSTRACT FROM AUTHOR]

Covalent organic frameworks (COFs), as a novel crystalline porous adsorbent, have been attracting significant attention for their synthesis and application exploration due to the advantages of designability, stability, and functionalization. Herein, through increasing the concentration of the acid catalyst, a facile solution-refluxing synthesis method was developed for the preparation of a three-dimensional dynamic COF material, COF-300, with high yields (>90%) and high space–time yields (>28 kg m–3 day–1). This synthesis method not only permits gram-scale synthesis, but also yields products that well maintain porosity and unique guest-dependent dynamic behavior. Moreover, the catalytic activity of COF-300 as a metal-free photocatalyst was explored for the first time. Under 365 nm ultra-violet light irradiation, COF-300 can effectively catalyze the dye degradation (>99%) in wastewater with good recyclability. By adding magnetic Fe3O4 nanoparticles into the solution-refluxing synthesis of COF-300, Fe3O4/COF-300 nanocomposites can be obtained and used as magnetically recyclable photocatalysts, demonstrating the superiority of this facile synthesis procedure. Our study provides new insights for the preparation of COF materials and a constructive exploration for their water treatment application. [ABSTRACT FROM AUTHOR]

Abstract: The cytotoxicity of lingshuiol, a novel polyhydroxy compound with a linear carbon-chain isolated from the cultured marine dinoflagellate Amphidinium sp., and that of amphidinol 2 (AM2) was compared with hepatocytes. Both lingshuiol and AM2 were toxic to primary rat hepatocytes with IC50 values of 0.21 and 6.4μM, respectively. Meanwhile, lingshuiol or AM2 caused a rapid mitochondrial swelling and leakage of Ca2+, underlying the change in permeability of mitochondria. Cyclosporin A, a specific inhibitor of mitochondrial permeability transition (MPT), could not affect these effects, indicating that CsA-sensitive MPT was not involved in the permeabilizing effects of lingshuiol or AM2. Sytox green tests further demonstrated that lingshuiol had a much stronger permeabilizing activity than AM2. Taken together, these results disclosed that lingshuiol had potent membrane permeabilizing activities, which might account for its cytotoxic effect. [Copyright &y& Elsevier]

Shape complementarity is a biological craft for precisely binding substrates at protein–protein interfaces. An analogy to such a function can be drawn conceptually for crystalline porous solids; yet the manifested entities are rare in reticular chemistry. The bottleneck‐shaped pores carved out of a metal‐organic framework, Zn(MIBA)2 (aka. MAF‐stu‐13), can perfectly accommodate benzene molecules. Remarkably, its framework adapts to the optimal guest binding‐the enhanced host–guest interactions in the neck in turn minimize the guest‐guest repulsion in the pore to the extent it turns into attraction‐as demonstrated by the combined X‐ray structural and DFT computational studies. This adaptive material can be used for liquid‐phase production of ultrahigh‐purity (≥99 %) cyclohexane, achieving a balance between uptake capacity and separation selectivity and surpassing the performances of other porous and nonporous crystals reported recently (e.g. product purity 99.4 % vs. 97.5 % to date). [ABSTRACT FROM AUTHOR]

Shape complementarity is a biological craft for precisely binding substrates at protein–protein interfaces. An analogy to such a function can be drawn conceptually for crystalline porous solids; yet the manifested entities are rare in reticular chemistry. The bottleneck‐shaped pores carved out of a metal‐organic framework, Zn(MIBA)2 (aka. MAF‐stu‐13), can perfectly accommodate benzene molecules. Remarkably, its framework adapts to the optimal guest binding‐the enhanced host–guest interactions in the neck in turn minimize the guest‐guest repulsion in the pore to the extent it turns into attraction‐as demonstrated by the combined X‐ray structural and DFT computational studies. This adaptive material can be used for liquid‐phase production of ultrahigh‐purity (≥99 %) cyclohexane, achieving a balance between uptake capacity and separation selectivity and surpassing the performances of other porous and nonporous crystals reported recently (e.g. product purity 99.4 % vs. 97.5 % to date). [ABSTRACT FROM AUTHOR]

Rare gas containing cations with general formula [Rg, B, 2F]+ have been investigated theoretically by second-order Mo\ller-Plesset perturbation, coupled cluster, and complete active space self-consistent field levels of theory with correlation-consistent basis sets. Totally two types of minima, i.e., boron centered C2v symmetried RgBF2+ (Rg = Ar, Kr, and Xe) which can be viewed as loss of F- from FRgBF2 and linear FRgBF+ (Rg = Kr and Xe) are obtained at the CCSD(T)/aug-cc-pVTZ/SDD and CASSCF(10,8)/aug-cc-pVTZ/SDD levels, respectively. It is shown that the RgBF2+ are global minima followed by FRgBF+ at 170.9 and 142.2 kcal/mol on the singlet potential-energy surfaces of [Rg, B, 2F]+ (Rg = Kr and Xe) at the CASPT2(10,8) /aug-cc-pVTZ/SDD//CASSCF(10,8)/aug-cc-pVTZ/SDD, respectively. The interconversion barrier heights between RgBF2+ and FRgBF+ (Rg = Kr and Xe) are at least 39 kcal/mol. In addition, no dissociation transition state associated with RgBF2+ and FRgBF+ can be found. This suggests that RgBF2+ (Rg = Ar, Kr, and Xe) can exist as both thermodynamically and kinetically stable species, while linear FRgBF+ (Rg = Kr and Xe) can exist as metastable species compared with the lowest dissociation limit energies just like isoelectronic linear FRgBO and FRgBN-. From natural bond orbital and atoms-in-molecules calculations, it is found that the positive charge is mainly located on Rg and boron atoms for both types of minima, the Rg-B bonds of ArBF2+, KrBF2+, and XeBF2+ are mostly electrostatic, thus can be viewed as ion-induced dipole interaction; while that of linear FKrBF+ and FXeBF+ are covalent in nature. The previous experimental observation of ArBF2+ by Pepi et al. [J. Phys. Chem. B. 110, 4492 (2006)] should correspond to C2v minimum. The presently predicted spectroscopies of KrBF2+, XeBF2+, FKrBF+, and FXeBF+ should be helpful for their experimental identification in the future. [ABSTRACT FROM AUTHOR]

[Display omitted] • Near defect-free and defect-rich UiO-66-type MOFs were successfully prepared. • Affecting mechanism of defects on CO 2 capture performance was elucidated. • Importance of thermal treatment for CO 2 capture performance was illustrated. • Necessity of identifying local fine structure for CO 2 capture evaluation was noted. Carbon capture and storage (CCS) technology is currently an essential response to the global warming problem caused by excessive CO 2 emissions. Efficient and reproducible adsorbents for flue gas treatment play an important role in CCS technology, and metal–organic frameworks (MOFs) are considered to be ideal candidates by virtue of their designable CO 2 sorption sites. However, carbon capture performance evaluation and reproducibility of MOFs still hinder their application promotion in industrial production. In this work, an extended UiO-66-type MOF based on 1,4-naphthalenedicarboxylate, was successfully synthesized in both a near defect-free form (UiO-66N) and a defect-rich form (DUiO-66N), for exploring the influence of crystalline defects and thermal treatments on carbon capture performance. Although powder X-ray diffraction showed that UiO-66N and DUiO-66N possessed the same crystalline phase, transmission electron microscopy, thermalgravimetric analyse and gas/dye sorption confirmed the presence of crystalline defects and the variation of porosity in DUiO-66N. CO 2 sorption isotherms and flue gas breakthrough experiments revealed the defect-induced improved carbon capture performance, which was also supported by density functional theory. Meanwhile, the metastability of defects required low thermal treatment temperatures for activation and regeneration thus maintaining the superior carbon capture performance. These findings suggested that in reproducing and evaluating the carbon capture performance of MOFs, it cannot rely only on the global crystalline phase judgment, but needs to identify the local fine structure as well as optimize activation and regeneration conditions. [ABSTRACT FROM AUTHOR]

Abstract: Treatment of the methanolic solution of 2-(2-hydroxyphenyl)-1,3-bis[4-(2-hydroxy-phenyl)-3-azabut-3-enyl]-1,3- imidazoline (H3L) and ZnSO4 ·7H2O affords the solvated multiplex [Zn2(SO4)(L)]2[Zn(H2O)6]·3H2O·0.75CH3OH (1) which uniquely contains anionic dizinc complexes of L3− as components and shows photoluminescence at room temperature. [Copyright &y& Elsevier]

The synthesis and crystal structure of a new one-dimensional mixed-ligand Cu(I) coordination polymer, [(PPh3)2Cu2(μ-I)2(μ-4,4′-bpy)]n (4,4′-bpy=4,4′-bipydine) are reported. The neutral polymer consists of (PPh3)2Cu2(μ-I)2(μ-4,4′-bpy) units bridged by 4,4′-bpy to construct an infinite chain architecture. Crystal data: C23H19CuINP, Mr=530.80, Triclinic space group (P1, No. 2), a=9.2279(8) A˚, b=9.4014(8) A˚, c=13.3663(12) A˚, α=107.445(2)°, β=106.707(2)°, γ=93.479(2)°, V=1045.8(2) A˚3, Dcalc=1.686 g m−3, Z=2. The solid state of the complex is luminescent with a peak maximum at 535 nm, upon excitation at 300–400 nm at room temperature. The emission is assigned to Copper(I) to 4,4′-bpy charge transfer (MLCT). [Copyright &y& Elsevier]

In the evolution of metal–organic frameworks (MOFs) for carbon capture, a lasting challenge is to strike a balance between high uptake capacity/selectivity and low energy cost for regeneration. Meanwhile, these man‐made materials have to survive from practical demands such as stability under harsh conditions and feasibility of scale‐up synthesis. Reported here is a new MOF, Zn(imPim) (aka. MAF‐stu‐1), with an imidazole derivative ligand, featuring binding pockets that can accommodate CO2 molecules in a fit‐like‐a‐glove manner. Such a high degree of shape complementarity allows direct observation of the loaded CO2 in the pockets, and warrants its optimal carbon capture performances exceeding the best‐performing MOFs nowadays. Coupled with the record thermal (up to 680 °C) and chemical stability, as well as rapid large‐scale production, both encoded in the material design, Zn(imPim) represents a most competitive candidate to tackle the immediate problems of carbon dioxide capture. [ABSTRACT FROM AUTHOR]

In the evolution of metal–organic frameworks (MOFs) for carbon capture, a lasting challenge is to strike a balance between high uptake capacity/selectivity and low energy cost for regeneration. Meanwhile, these man‐made materials have to survive from practical demands such as stability under harsh conditions and feasibility of scale‐up synthesis. Reported here is a new MOF, Zn(imPim) (aka. MAF‐stu‐1), with an imidazole derivative ligand, featuring binding pockets that can accommodate CO2 molecules in a fit‐like‐a‐glove manner. Such a high degree of shape complementarity allows direct observation of the loaded CO2 in the pockets, and warrants its optimal carbon capture performances exceeding the best‐performing MOFs nowadays. Coupled with the record thermal (up to 680 °C) and chemical stability, as well as rapid large‐scale production, both encoded in the material design, Zn(imPim) represents a most competitive candidate to tackle the immediate problems of carbon dioxide capture. [ABSTRACT FROM AUTHOR]

In the evolution of metal–organic frameworks (MOFs) for carbon capture, a lasting challenge is to strike a balance between high uptake capacity/selectivity and low energy cost for regeneration. Meanwhile, these man‐made materials have to survive from practical demands such as stability under harsh conditions and feasibility of scale‐up synthesis. Reported here is a new MOF, Zn(imPim) (aka. MAF‐stu‐1), with an imidazole derivative ligand, featuring binding pockets that can accommodate CO2 molecules in a fit‐like‐a‐glove manner. Such a high degree of shape complementarity allows direct observation of the loaded CO2 in the pockets, and warrants its optimal carbon capture performances exceeding the best‐performing MOFs nowadays. Coupled with the record thermal (up to 680 °C) and chemical stability, as well as rapid large‐scale production, both encoded in the material design, Zn(imPim) represents a most competitive candidate to tackle the immediate problems of carbon dioxide capture. [ABSTRACT FROM AUTHOR]

Metal nanoparticles (NPs) stabilized by MOFs are very promising for catalysis, whereas introduction of C60 into MOFs has been very rarely used, and there was no report for their cooperative catalysis in organic syntheses. In this work, C60@UiO‐67 was synthesized by a one‐pot method, so that C60 is uniformly distributed on UiO‐67 in molecular form. Pd NPs coordinating with C60 have been successfully embedded into the framework. The obtained multifunctional C60Pdn@UiO‐67 catalyst exhibits remarkable synergistic catalytic activity in cascade reactions under mild conditions, where UiO‐67 affords Lewis acidity and C60Pdn offers higher hydrogenation activity relative to solely Pd NPs. Composite catalyst: A new material consisting of Pd, C60 and MOF was designed and synthesized, and showed high catalytic activity in a tandem hydrogenation reaction. The different components of the material acted synergistically to improve the conversion performance. [ABSTRACT FROM AUTHOR]

The title MOF features a potential uninodal zeolite net, uks, which has never been found for real zeolites or zeolite-like MOFs. This rare structure exhibits specific anion binding of N3− over SCN− in water, which reverses the Hofmeister series. [ABSTRACT FROM AUTHOR]

A series of Cu4I4 clusters (1–5) supported by two pyrazolate-type zwitterionic ligands N-methyl-[4-(5-R-pyrazolyl)]pyridinium (1: R = tert-butyl; 2: R = trifluoromethyl; 3, 4, 5: R = phenyl) have been prepared and fully characterized. These compounds all exhibit a distorted “octahedral” geometry and their luminescence behavior is quite distinct from those of previously reported tetranuclear copper halide clusters. The crystalline powders of all five clusters only show a single broad low-energy (LE) emission band from 300 to 80 K. Cluster 1 shows temperature-independent orange phosphorescence despite a slight blue-shift of the low-energy flank upon cooling. Intriguingly, for clusters 2–5, a hypsochromic phenomenon is clearly observed by decreasing the temperature. Using DFT/TDDFT calculations, we find that the nature of the electronic transitions responsible for the LE emission is dominated by the steric demand and/or electronic characteristics of the substituents on the pyrazolyl moiety. Specially, contribution of cuprophilic interactions in the lowest triplet excited states is ruled out by the rigid ligands. The single LE emission of 1 and 2 is attributed to pure 3ILCT and 3(M + X)LCT transitions, respectively, while the emission of 3 and 4 is assigned to a mixed 3ILCT and 3(M + X)LCT transition with different proportions. [ABSTRACT FROM AUTHOR]

As the main organic pollutants in wastewater, antibiotics and organic dyes are harmful to the environment and public health, and their removal is important but challenging. In this work, highly porous 3D metal-organic frameworks (MOFs) [M2(PDAD)(H2O)] n (PCN-124-stu; M=Cu, Zn; H4PDAD = 5,5′-(pyridine-3,5-dicarbonyl)bis(azanediyl)diisophthalic acid) were synthesized, and PCN-124-stu(Cu) shows excellent chemical and thermal stability. PCN-124-stu(Cu) was used as a host for efficient extraction of various organic dyes, especially the large-molecule dye Coomassie brilliant blue, and fluoroquinolones from water, in comparison with five common MOFs, zeolite 13X, and activated carbon. PCN-124-stu(Cu) exhibits absolute predominance for fluoroquinolone adsorption among these microporous materials because of the H-bonds between fluoroquinolone molecules and the amide groups in the frameworks, except for MIL-100(Cr), which is a mesoporous MOF. Moreover, PCN-124-stu(Cu) could release fluoroquinolones slowly in physiological saline and retained its framework structure after four adsorption/desorption cycles. In addition, PCN-124-stu(Cu) can be used as a platform for selective adsorption of CO2/CH4. [ABSTRACT FROM AUTHOR]

The racemic conglomerate (1P-NH3 + 1M-NH3) and enantioenriched bulk samples (1P-H2O or 1M-NH3) of Co(ii) metal–organic frameworks were obtained from achiral precursors under different solvothermal conditions. The bulk homochirality was generated through asymmetrical crystallization in the absence of any chiral additives confirmed by single crystal X-ray diffraction and CD spectroscopy. [ABSTRACT FROM AUTHOR]

Biological and artificial molecules and assemblies capable of supramolecular recognition, especially those with nucleobase pairing, usually rely on autonomous or collective binding to function. Advanced site-specific recognition takes advantage of cooperative spatial effects, as in local folding in protein-DNA binding. Herein, we report a new nucleobase-tagged metal-organic framework (MOF), namely ZnBTCA (BTC=benzene-1,3,5-tricarboxyl, A=adenine), in which the exposed Watson-Crick faces of adenine residues are immobilized periodically on the interior crystalline surface. Systematic control experiments demonstrated the cooperation of the open Watson-Crick sites and spatial effects within the nanopores, and thermodynamic and kinetic studies revealed a hysteretic host-guest interaction attributed to mild chemisorption. We further exploited this behavior for adenine-thymine binding within the constrained pores, and a globally adaptive response of the MOF host was observed. [ABSTRACT FROM AUTHOR]

Biological and artificial molecules and assemblies capable of supramolecular recognition, especially those with nucleobase pairing, usually rely on autonomous or collective binding to function. Advanced site-specific recognition takes advantage of cooperative spatial effects, as in local folding in protein-DNA binding. Herein, we report a new nucleobase-tagged metal-organic framework (MOF), namely ZnBTCA (BTC=benzene-1,3,5-tricarboxyl, A=adenine), in which the exposed Watson-Crick faces of adenine residues are immobilized periodically on the interior crystalline surface. Systematic control experiments demonstrated the cooperation of the open Watson-Crick sites and spatial effects within the nanopores, and thermodynamic and kinetic studies revealed a hysteretic host-guest interaction attributed to mild chemisorption. We further exploited this behavior for adenine-thymine binding within the constrained pores, and a globally adaptive response of the MOF host was observed. [ABSTRACT FROM AUTHOR]

It was found in the present study that combined use of fusidic acid (FA) and berberine chloride (BBR) offered an in vitro synergistic action against 7 of the 30 clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, with a fractional inhibitory concentration (FIC) index ranging from 0.5 to 0.19. This synergistic effect was most pronounced on MRSA 4806, an FA-resistant isolate, with a minimum inhibitory concentration (MIC) value of 1,024 μg/ml. The time-kill curve experiment showed that FA plus BBR yielded a 4.2 log c.f.u./ml reduction in the number of MRSA 4806 bacteria after 24-h incubation as compared with BBR alone. Viable count analysis showed that FA plus BBR produced a 3.0 log c.f.u./ml decrease in biofilm formation and a 1.5 log c.f.u./ml decrease in mature biofilm in viable cell density as compared with BBR alone. In addition, phase contrast micrographs confirmed that biofilm formation was significantly inhibited and mature biofilm was obviously destructed when FA was used in combination with BBR. These results provide evidence that combined use of FA and BBR may prove to be a promising clinical therapeutic strategy against MRSA. [ABSTRACT FROM AUTHOR]

Please cite this paper as: Li et al. (2012) Immunogenicity and safety of a 2009 pandemic influenza A (H1N1) monovalent vaccine in Chinese infants aged 6-35 months: a randomized, double-blind, controlled phase I clinical trial. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12028. Objectives The goal of this double-blind, randomized, controlled clinical trial was to assess the safety and immunogenicity of two different doses of a monovalent split-virion 2009 pandemic influenza A/H1N1 vaccine without adjuvant in Chinese infants aged 6-35 months. Design and setting Subjects were randomly assigned to receive either a 2009 pandemic (H1N1) vaccine containing 7.5 or 15 μg haemagglutinin (HA) or a seasonal influenza vaccine. 2 doses of the H1N1 vaccines or the seasonal influenza vaccine were given 21 days apart in younger infants aged 6-23 months or older infants aged 24-35 months. Sample Serum samples were collected immediately before the first injection and before and 21 days after the second injection. Main outcome measures Primary outcomes were haemagglutinin inhibition (HI) antibody responses 21 days following each vaccination. Safety was monitoring throughout the study. Results The first vaccination of 7.5 μg and 15 μg H1N1 vaccine induced seroprotective antibody titers (HI titers ≥ 1: 40) in 42.9-57.4% of younger infants and 49.1-61.0% older infants. Immune responses after completion of the two dose schedule were comparable in both age groups with seroprotective rates of 91-98% in each vaccine and age group and GMTs of 173-263. The H1N1 vaccine elicited similar rates of local and systemic adverse reactions as the seasonal influenza vaccine. Conclusions The 2009 pandemic influenza A /H1N1 vaccine were highly immunogenic in infants aged 6-35 months, and displayed a safety and reactogenicity profile similar to the seasonal influenza vaccine. Trial registration ClinicalTrial.gov identifier: NCT01047202 [ABSTRACT FROM AUTHOR]

A rod‐packing, breathing MOF (1), with two crystalline structural intermediates (1 a and 1 b; H2btca=benzotriazole‐5‐carboxylic acid) has been investigated. An underlying net approach for analyzing possible breathing MOFs, and a set of geometric parameters that can quantitatively describe such a breathing structural feature, are suggested. The 3D luminescent MOF is a promising candidate for specific sensors with exceptional sorption capacity. [ABSTRACT FROM AUTHOR]

Candida infections have become an increasingly significant problem, mainly because of the widespread nature of Candida and drug resistance. There is an urgent need to develop new classes of drugs for the treatment of opportunistic Candida infections, especially in medically complex patients. Previous studies have confirmed that 2-amino-nonyl-6-methoxyl-tetralin muriate (10b) possesses powerful antifungal activity in vitro against Candia albicans. To clarify the underlying action mechanism, an oligonucleotide microarray study was performed in C. albicans SC5314 without and with 10b treatment. The analytical results showed that energy metabolism-related genes, including glycolysis-related genes ( PFK1, CDC19 and HXK2), fermentation-related genes ( PDC11, ALD5 and ADH1) and respiratory electron transport chain-related genes ( CBP3, COR1 and QCR8), were downregulated significantly. Functional analysis revealed that 10b treatment increased the generation of endogenous reactive oxygen species, and decreased mitochondrial membrane potential, ubiquinone-cytochrome c reductase (complex III) activity and intracellular ATP levels in C. albicans SC5314. Also, addition of the antioxidant ascorbic acid reduced the antifungal activity of 10b significantly. These results suggest that mitochondrial aerobic respiration shift and endogenous reactive oxygen species augmentation might contribute to the antifungal activity of 10b against C. albicans. This information may prove to be useful for the development of new strategies to treat Candida infections. 10b treatment decreased the expression of energy metabolism-related genes, increased generation of endogenous reactive oxygen species (ROS), decreased mitochondrial membrane potential (AM·m), ubiquinone-cytochrome C reductase (complex III) activity and intracellular ATP level in Candida albicans SC5314 strain. Also, addition of antioxidant ascorbic acid (AA) reduced the antifungal activity of 10b significantly. [ABSTRACT FROM AUTHOR]

An experimental setup is built for the measurement of monochromatic incident photon-to-electron conversion efficiency (IPCE) of solar cells. With this setup, three kinds of IPCE measuring methods as well as the convenient switching between them are achieved. The setup can also measure the response time and waveform of the short-circuit current of solar cell. Using this setup, IPCE results of dye-sensitized solar cells (DSCs) are determined and compared under different illumination conditions with each method. It is found that the IPCE values measured by AC method involving the lock-in technique are sincerely influenced by modulation frequency and bias illumination. Measurements of the response time and waveform of short-circuit current have revealed that this effect can be explained by the slow response of DSCs. To get accurate IPCE values by this method, the measurement should be carried out with a low modulation frequency and under bias illumination. The IPCE values measured by DC method under the bias light illumination will be disturbed since the short-circuit current increased with time continuously due to the temperature rise of DSC. Therefore, temperature control of DSC is considered necessary for IPCE measurement especially in DC method with bias light illumination. Additionally, high bias light intensity (>2 sun) is found to decrease the IPCE values due to the ion transport limitation of the electrolyte. [ABSTRACT FROM AUTHOR]

Abstract: A first example of 1D coordination polymer [MnTHPP·H2O·(DMF)2 (1)] with right-handed helicity and opticity was successfully assembled. Crystal analyses indicate that the right-handed helical assembly is based on coordination bonds from peripheral to center, associating with the saddle distortion of the molecular planes. In its crystal architecture, MnTHPP [manganese (III) ion coordinated by 5,10,15,20-tetra(4-hydroxyphenyl) porphyrin] molecules were ligated each other via the axial coordination between –PhO− → MnIII (peripheral to center model, from the peripherally deprotonated hydroxyphenyl to the central metal of the neighbor molecule) to construct the right-handed helices, and the helices are sustained by plentiful hydrogen bonding. Meanwhile DMF molecules are entrapped within the voids among the helices. This is a rare example of the multiporphyrin arrays with right-handed helices bearing opticity. [Copyright &y& Elsevier]

Abstract: The structures, isomerization and spectroscopies of GeSiN and GeCP radicals are explored at density functional theory and ab initio levels. For GeSiN, the global minimum is linear GeNSi 1, in agreement of the mass spectra detection, which can be qualitatively described as a resonance hybrid of |Ge;Si|• and •|Ge–N|e the latter contributes more. As to GeCP, the lowest-lying isomer is linear GeCP 1 resonating between •|Ge–Ceh name="dbnd" />P|• with the former contributes more, followed by a cyclic isomer cGeCP 2 at 8.8kcal/mol. All above three species with large kinetic stability (about 10kcal/mol barrier) should be experimentally important. [Copyright &y& Elsevier]

Abstract: Hydrothermal reactions of pyridyl-2,6-dicarboxylic acid (H2PDC) and NiCl2 ·6H2O in the presence of NaOH and KOH, respectively afforded the products, {[Ni(PDC)(Cl)](Na)(H2O)/3} n (1) and K2[Ni(PDC)2]·7H2O (2), of which 1 was characterized consisting of 3-D porous framework and [Na6(H2O)]6+ inclusions, and 2 was a mononuclear complex with potassium hydrate as counterion. [Copyright &y& Elsevier]

• A highly sensitive and stable HBV DNA biosensor is prepared by a simple method. • ErGO-supported Cu-MOF shows a good affinity to probe DNA. • The biosensor integrates Cu-MOF as signal probe with ErGO as signal amplification. • The biosensor shows good selectivity, reproducibility, and regeneration. • The biosensor acts as a good candidate to measure HBV DNA in biological samples. It is still a very challenging work to develop new and more effective methods for detecting Hepatitis B virus (HBV). In this work, a new simple electrochemical biosensor with high sensitivity and stability was constructed for detecting HBV DNA by combining the electroactive Cu-MOF as a signal nanoprobe and multi-site matrix and electroreduced graphene oxide (ErGO) as signal amplification material. Cu-MOF exhibits good affinity to probe DNA through covalent attachment, which can further stabilize DNA probe. The probe DNA density and the hybridization efficiency of this electrochemical DNA biosensor was 9.48 × 1013 molecules cm−2 and 89.9%, respectively. Under optimal conditions, the electrochemical DNA biosensor had an excellent performance toward HBV DNA determination with a wide linear range of 50.0 fM to 10.0 nM, and a low limit of detection (LOD) of 5.2 fM, more sensitive than other reported electrochemical HBV DNA biosensors. Moreover, the new sensor was used to measure HBV DNA in human serum and urine samples with sound results. This work also provides some insights for the construction of other electrochemical DNA biosensors. [ABSTRACT FROM AUTHOR]

A new highly porous MOF platform, namely PCN‐124‐stu was elegantly designed and prepared. The PCN‐124‐stu(Cu) displays not only high surface area, but also excellent thermal and chemical stability. The MOFs efficiently adsorbed dyes and fluoroquinolones in water, showing promise for water purification. Based on the work above, the cover depicts a traditional Chinese‐style landscape‐painting in which PCN‐124‐stu(Cu) cleanses the water and provides an attractive environment for all creatures. More information can be found in the Full Paper by X.‐C. Huang et al. on page 13058. [ABSTRACT FROM AUTHOR]