1. Docetaxel-loaded composite nanoparticles formed by a temperature-induced phase transition for cancer therapy.
- Author
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Yuk, Soon H, Oh, Keun S, Park, Jinah, Lee, Eun H, Kim, Kwangmeyung, and Kwon, Ick C
- Subjects
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DOCETAXEL , *CANCER treatment , *NANOPARTICLES , *PHASE transitions , *SOY oil , *TUMOR growth - Abstract
Docetaxel-loaded composite nanoparticles were prepared by temperature-induced phase transition of a mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing docetaxel. Liquid soybean oil/Tween 80 was used as a solubilizer for docetaxel and Pluronic F-68 to stabilize the liquid soybean oil/Tween 80 containing docetaxel. The phase transition was performed at low temperature to avoid degradation. The docetaxel composite nanoparticles were injected into the tail veins of tumor-bearing mice to evaluate the composite delivery system for the release pattern and the tumor growth. The tumor-targeting capability of composite nanoparticles was verified by noninvasive live animal imaging for the time-dependent excretion profile, the in vivo biodistribution, and the circulation time. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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