Search

Antibiotic resistant pathogen pose an ever increasing threat to mankind at any time of cost. The bacteria accumulate and encased in an extracellular matrix are called a biofilm and are challenging to eradicate with antibiotic treatment. Pseudomonas aeruginosa biofilm is particularly deadly in cystic fibrosis patients and is the root cause of chronic wounds, chronic -obstructive pulmonary disease (COPD), and medical device-related infections. Recent studies have shown that P. aeruginosa biofilm reported a higher prevalence in causing drug resistance and infection in intensive care units (ICUs). Bacteria within the biofilm are more tolerant of antibiotics; hence it is critically important to develop effective strategies to eradicate biofilm-related infections. Dispersion of biofilm is one of the major factors to tackle the antibiotic tolerance of biofilms. The purpose of this review is to summarize and provide a critical written account of the efficient approaches for biofilm dispersal and thus to make the dispersed bacterial cells susceptible to antibiotics. This points the way forward for further research in combating antibiotic resistance and the successful treating of biofilm-associated infections. [ABSTRACT FROM AUTHOR]