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Nonsurgical endodontic management of the nonvital posterior tooth with large periapical radiolucency has been suggested as conservative approach in endodontics in existing literature. However, complete disinfection of the infected root canals has been a challenge in endodontic procedure. Recently, various types of lasers have emerged as the effective and successful way for achieving in-depth elimination of bacteria and also for healing of periapical lesions. However, there is a scarcity of published case report articles about laser-assisted endodontic therapy in combination with rotary files system for the noninvasive management of large periapical lesion associated with nonvital posterior teeth in claustrophobic child patients. Hence, the aim of this article is to present the pediatric case report about the successful nonsurgical orthograde endodontic treatment by employing diode laser of 810 nm wavelength for the disinfection of the infected root canals and resolution of periradicular radiolucency followed by functional rehabilitation of the treated tooth with preformed stainless steel crown within the shorter period. [ABSTRACT FROM AUTHOR]