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In coal seam gas (CSG) coproduction wells, due to the different production pressures of CSG production layer at different depths, the interlayer interference in wellbore seriously affects the gas production of a coproduction well. To effectively suppress the interlayer interference of the wellbore, a wellbore pressure distribution method for a two-layer coproduction well is proposed. Based on the analysis of the factors influencing the flow pressure distribution in the wellbore of two-layer coproduction wells, a method of coproduction flow pressure adjustment by regulating the wellhead pressure and the depth of the dynamic fluid level was established in this paper. The results show that wellhead pressure can directly affect the production pressure of two layers. The variation in layer 1 output mainly affects the pressure difference between the wellhead pressure and the pressure at the depth of layer 1, which has little effect on the pressure difference between layer 1 and 2. An increase in gas production from layer 2 would not only cause a pressure increase in layer 1, but also result in a reduction of the production pressure at layer 2. The maximum pressure gradient of the gas section is 0.14 MPa/100 m, and the pressure gradient of the gas–liquid section is 0.53–1.0 MPa/100 m. [ABSTRACT FROM AUTHOR]