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Background: Increase in blood pressure is generally termed as hypertension which is one of the common causes of cardiovascular diseases. Despite the several treatment methods, hypertension stands to be the major concern in developing countries. Angiotensin converting enzyme is one of the key contributors in regulating blood pressure where improper activation of angiotensisn leads to hypertension. Mimosa pudica plant has been reported to exhibit several therapeutic properties and thus the current study was focused on evaluating antihypertensive property of phytochemicals found in the Mimosa pudica extract. Materials and Methods: Methanol extract of Mimosa pudica was examined for presence of potential phytochemicals by GC-MS and molecular docking studies were carried out using Autodock 4.2. Results: 07 phytochemicals were identified in the methanol extract of Mimosa pudica. Further molecular docking studies against angiotensin converting enzyme (ACE) was carried out and among the list of test compounds 9,12-octadecadienoic acid showed least binding energy with -6.6 kJ. Conclusion: Compounds selected as phytochemicals of Mimosa pudica from methanol extract of Mimosa pudica, specially 9,12-octadecadienoic acid considered for further evaluation of antihypertensive and cardioprotective activity. [ABSTRACT FROM AUTHOR]

Abstract: A new tetra-aza macrocyclic ligand, L (C24H16N12O2S4) and its complexes of type, [MLCl2] and [CuL]Cl2 (where M=Ni(II), Co(II); L= N,N′-(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis{2-[(5-benzene-1,3-diyl-1,3,4-thiadiazol-2-yl)amino]acetamide}) were synthesized and characterized by the spectral and analytical techniques. An octahedral geometry has been proposed for Ni(II) and Co(II) complexes while Cu(II) complex exhibit a square planar geometry. All the synthesized metal complexes were screened for their in vitro antimicrobial activity against selected species of pathogenic bacteria and fungi. The binding property of the complexes with CT-DNA was studied by absorption spectral analysis, followed by viscosity measurement and thermal denaturation studies. The photo induced cleavage studies revealed that the complexes possess photonuclease property against pUC19 DNA under UV–visible irradiation. [Copyright &y& Elsevier]

A series of novel benzothiazole based azo dyes were synthesized and fully characterized by using different analytical techniques. The antioxidant activity of synthesized azo dyes was studied with the DPPH, hydrogen peroxide, metal chelating and nitric oxide radical methods and compared with the known antioxidant ascorbic acid. Further, the anticancer properties of synthesized azo dyes were carried out against breast cancer (MCF-7) cell lines by MTT assay and results revealed that the synthesized compounds exhibited good anticancer property in micro-molar range. Additionally, the anti-inflammatory activities of target compounds were also investigated by protein denaturation method and were found to have effective anti-inflammatory property. In order to predict the binding modes and binding affinity of synthesized compounds, they were docked into the active sites of protein B-cell lymphoma-extra-large (Bcl-xL) to predict their anticancer property. The synthesized compounds were found to have good affinity for B-cell lymphoma-extra-large (Bcl-xL). A good correlation was found between in-silico docking analysis and in biological screening of all synthesized azo dyes with less binding energies and higher inhibition constants value against the target protein. Results of anti-proliferative activity on Breast cancer cell line (MCF-7) at different concentration of the compound 1a. Image 1 • Eleven different benzothiazole based azo dyes have been synthesized and characterized. • Presence of substituent's influences significantly on the absorption spectra of dyes. • Anti oxidant and anti-inflammatory properties of synthesized azo dyes was evaluated. • Anticancer properties of synthesized azo dyes was investigated against human breast cancer cell line (MCF-7). • In-silico docking studies was performed for synthesized azo dyes to predict their active sites towards the B-cell lymphoma-extra-large (BCl-XL). [ABSTRACT FROM AUTHOR]