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Lu2SiO5:Ce (LSO) scintillator is a relatively new luminescent material which has been successfully applied in positron emission tomography systems. Since it has been recently commercially available in powder form, it could be of value to investigate its performance for use in x-ray projection imaging as both physical and scintillating properties indicate a promising material for such applications. In the present study, a custom and validated Monte Carlo simulation code was used in order to examine the performance of LSO, under diagnostic radiology (mammography and general radiography) conditions. The Monte Carlo code was based on a model using Mie scattering theory for the description of light attenuation. Imaging characteristics, related to image brightness, spatial resolution and noise of LSO screens were predicted using only physical parameters of the phosphor. The overall performance of LSO powder phosphor screens was investigated in terms of the: (i) quantum detection efficiency (ii) emitted K-characteristic radiation (iii) luminescence efficiency (iv) modulation transfer function (v) Swank factor and (vi) zero-frequency detective quantum efficiency [DQE(0)]. Results were compared to the traditional rare-earth Gd2O2S:Tb (GOS) phosphor material. The relative luminescence efficiency of LSO phosphor was found inferior to that of GOS. This is due to the lower intrinsic conversion efficiency of LSO (0.08 instead of 0.15 of GOS) and the relatively high light extinction coefficient mext of this phosphor (0.239 μm-1 instead of 0.218 μm-1 for GOS). However, the property of increased light extinction combined with the rather sharp angular distribution of scattered light photons (anisotropy factor g=0.624 for LSO instead of 0.494 for GOS) reduce lateral light spreading and improve spatial resolution. In addition, LSO screens were found to exhibit better x-ray absorption as well as higher signal to noise transfer properties in the energy range from 18 keV up to 50.2 keV (e.g. DQE(0)=0.62 at 18 keV and for 34 mg/cm2, instead of 0.58 for GOS). The results indicate that certain optical properties of LSO (optical extinction coefficient, scattering anisotropy factor) combined with the relatively high x-ray coefficients, make this material a promising phosphor which, under appropriate conditions, could be considered for use in x-ray projection imaging detectors. [ABSTRACT FROM AUTHOR]

The luminescence of (Lu, Y)2 SiO5 : Ce (LYSO:Ce) and Gd2 SiO5 : Ce (GSO:Ce) crystals was studied for use in tomographic medical x-ray imaging. LYSO:Ce and GSO:Ce are high density (7.1 g/cm3 and 6.71 g/cm3 respectively), high atomic number (71 for Lu and 64 for Gd), non-hydroscopic, and short decay time (40 ns and 60 ns respectively) scintillators. Evaluation was performed by determining: 1) the luminescence efficiency (LE) (emitted light energy flux over incident x-ray energy flux) in x-ray energies employed in general x-ray imaging (40-140 kVp) and in mammographic x-ray imaging (22-49 kVp), 2) the light emission spectrum, determined at various x-ray energies (22-140 kVp), and 3) the spectral compatibility to optical photon detectors, incorporated in medical imaging systems. Both scintillation materials exhibited adequately high LE in the x-ray diagnostic energy range, with LYSO:Ce's LE being distinctively higher. LYSO:Ce and GSO:Ce were found most compatible with the S-20 photocathode (0.9 for both materials) and adequately compatible to the amorphous silicon photodiode (0.74 for both materials), incorporated in many digital x-ray detectors. [ABSTRACT FROM AUTHOR]

Abstract: Lutetium–yttrium-based scintillators, such as LYSO:Ce, have a high effective atomic number, are non-hygroscopic, fast emitting materials, and promising candidates for use in positron emission imagers. The present study investigates the light emission characteristics of (Lu, Y)2SiO5:Ce (LYSO:Ce) single-crystal scintillator under X-ray imaging conditions. Also, the parameters related to the luminescence emission spectrum and emission efficiency were studied using experimental methods. Various X-ray tube voltages currently employed in X-ray imaging techniques were used. Measurements were performed using an experimental set-up based on a photomultiplier coupled to an integration sphere. In addition, the emission spectrum under UV and X-ray excitation was measured using an optical grating monochromator to determine the spectral compatibility of optical photon detectors incorporated in medical imaging systems. The absolute efficiency of LYSO:Ce was found to increase with increasing X-ray tube voltage (from 2.2EU at 22kVp to 22.4EU at 140kVp), while its spectrum, peaking at about 430nm, was found compatible with most optical detectors (photodiodes, photocathodes, charge coupled devices, etc.). The matching factor was estimated to range from 0.76 to 0.92 (for a silicon photodiode and for a GaAsP photocathode, respectively). [Copyright &y& Elsevier]

Gd2SiO5 :Ce (GSO:Ce) is a high-Z, nonhygroscopic fast emitting scintillator used in detectors of positron emission tomography (PET) systems. The purpose of this study was to evaluate the luminescence efficiency of GSO:Ce scintillator under irradiation conditions employed in X-ray medical imaging, since findings may be of value in novel applications such as computed tomography breast imaging or modern fast image producing X-ray computed tomography. To this aim the absolute luminescence efficiency (emitted light flux over X-ray exposure), the spectral matching factor (compatibility to optical detectors), and the effective efficiency (the product of absolute efficiency and spectral compatibility) were determined for X-ray tube voltages ranging from 20 to 140 kV. The efficiency of GSO:Ce was found to increase with increasing X-ray tube voltage, while the GSO:Ce spectrum, peaking at 440 and 490 nm, was found compatible to most optical detectors (photodiodes, photocathodes, and charge-coupled devices). [ABSTRACT FROM AUTHOR]

The aim of the present study is to introduce the detective quantum efficiency (DQE) for the image quality assessment of positron emission tomography (PET) scanners. For this purpose, a thin layer chromatography (TLC) plane source was simulated using a previously validated, scanner and source geometry, Monte Carlo (MC) model. The model was developed with the Geant4 application for tomographic emission (GATE) MC package and reconstructed images obtained with the software for tomographic image reconstruction (STIR), with cluster computing. The GE Discovery ST PET scanner was simulated by using a previously validated code. A plane source consisting of a TLC plate, was simulated by a layer of silica gel on aluminum (Al) foil substrate, immersed in 18F-FDG bath solution (1MBq). Image quality was assessed in terms of the modulation transfer function (MTF) and the normalized noise power spectrum (NNPS) in order to obtain the detective quantum efficiency (DQE). MTF curves were estimated from transverse reconstructed images of the plane source, whereas the NNPS data were estimated from the corresponding coronal images. Images were reconstructed by the maximum likelihood estimation ordered subsets maximum a posteriori one step late (MLE)-OS-MAP-OSL algorithm, by using various subsets 1–21) and iterations 1–20). MTF values were found to increase up to the 12th iteration whereas remain almost constant thereafter. However, the range of the increase in the MTF is limited as the number of subsets increases. The noise levels were found to increase with the corresponding increase of both the number of iterations and subsets. The maximum NNPS value (0.517 mm 2 ) was observed for the 420 MLEM-equivalent iterations reconstructed image at 0 cycles/mm. Finally DQE values were found to increase for spatial frequencies up to 0.038 cycles/mm and to decrease thereafter with the corresponding increase in both number of iterations and subsets. The maximum DQE value (0.48 at 0.038 cycles/mm) was obtained for the 8 MLEM-equivalent iterations image. The simulated PET evaluation method based on the TLC plane source can be useful in the quality control and in the further development of PET and SPECT scanners though GATE simulations. [ABSTRACT FROM AUTHOR]

The aim of the present study was to investigate the imaging transfer characteristics and the luminescence efficiency (XLE) of Gd2O2S\!\!\!\!:\!\!\!\!Eu powder scintillator for use in X-ray mammography detectors. Gd2O2S\!\!\!\!:\!\!\!\!Eu emits in the red part of the visible spectrum, having very good spectral compatibility with optical sensors employed in digital imaging systems. Three Gd2O2S\!\!\!:\!\!Eu powder scintillating screens, with coating thicknesses 33.1, 46.4 and 63.1 mg/cm^2, were prepared in our laboratory. The imaging performance of these screens was assessed by experimental determination of the modulation transfer function (MTF), the noise transfer function (NTF) and the detective quantum efficiency (DQE) as well as a single index image quality parameter such as the information capacity (IC). A theoretical model, describing radiation and light transfer, was used to fit experimental MTF data. This has allowed the estimation of optical attenuation coefficients of the scintillator. In addition, a previously validated Monte Carlo code, based on the X-ray attenuation properties and on the Mie light scattering theory, was used to estimate the X-ray detection efficiency, the Swank factor and the zero frequency DQE of the Gd2O2S\!\!\!:\!\!\!Eu scintillator. Results showed that Gd2O2S\!\!:\!\!Eu exhibits high MTF and DQE values, which are comparable to those of a commercially employed Gd2O2S\!\!:\!\!Tb screen. In addition Gd2O2S\!\!:\!\!Eu shows high compatibility (effective gain) to CCDs and to recently introduced CMOS based detectors. Considering our image quality parameters and luminescence efficiency results, this material can potentially be considered for use in digital X-ray mammography detectors. [ABSTRACT FROM AUTHOR]

Fundamental imaging performance in terms of Modulation Transfer Function (MTF), Noise Power Spectrum (NPS) and Detective Quantum Efficiency (DQE) was investigated for a high resolution CMOS based imaging sensor. The device consists of a 33.91 mg/cm^2~Gd_2 O _2 S:Tb scintillator screen, placed in direct contact with a CMOS photodiode array. The CMOS photodiode array, featuring 1200\,\times\,1600 pixels with a pixel pitch of 22.5 \mu m , was used as an optical photon detector. In addition to the conventional frequency dependent parameters characterizing image quality, image information content was assessed through the application of information capacity (IC). The MTF was measured using the slanted-edge method to avoid aliasing while the Normalized NPS (NNPS) was determined by two-dimensional (2D) Fourier transforming of uniformly exposed images. Both measurements were performed under the representative radiation quality (RQA) settings, RQA-5 (70 kVp digital-radiography) and RQA-M2 (28 kVp digital-mammography) recommended by the International Electrotechnical Commission Reports 62220-1 and 62220-1-2 respectively. The DQE was assessed from the measured MTF, NPS and the direct entrance surface air-Kerma (ESAK) obtained from X-ray spectra measurement with a portable cadmium telluride (CdTe) detector. The ESAK values ranged between 11–87 \muGy for RQA-5 and 6–40 \muGy for RQA-M2. Additionally the output electrons per X-ray photon of the detector and its signal transfer characteristics were assessed via an analytical model, within the framework of the linear cascaded systems (LCS) theory. It was found that the detector response function was linear for the exposure ranges under investigation. Additionally our results showed that for the same RQA quality the output electrons per X-ray photon, as well as the measured and analytically predicted MTF, were not significantly affected by ESAK. MTF and DQE where found better compared to previously published data for other CCD and CMOS sensors, while the NNPS appeared to be comparable in the frequency range under investigation (0–10 cycles/mm). [ABSTRACT FROM AUTHOR]

The aim of the present work is to study the performance of scintillators currently used in PET and animal PET systems, under conditions met in radiation therapy and PET/CT imaging. The results of this study will be useful in applications where both CT and PET photons as well as megavoltage cone beam CT (MV CBCT) photons could be detected using a common detector unit. To this aim crystal samples of GSO, LSO, LYSO, LuYAP and YAP scintillators, doped with cerium (Ce3+) were examined under a wide energy range of photon energies. Evaluation was performed by determining the absolute luminescence efficiency (emitted light flux over incident X-ray exposure) in the energy range employed in X-ray CT, in Nuclear Medicine (70 keV up to 662 keV) and in radiotherapy 6 MV (approx. 2.0 MeV mean energy)-18 MV (approx. 4.5 MeV mean energy). Measurements were performed using an experimental set-up based on a photomultiplier coupled to a light integration sphere. The emission spectrum under X-ray excitation was measured, using an optical grating monochromator, to determine the spectral compatibility to optical photon detectors incorporated in medical imaging systems. Maximum absolute luminescence efficiency values were observed at 70 keV for YAP:Ce and LuYAP:Ce and at 140 keV for LSO:Ce, LYSO:Ce and GSO:Ce. Highest absolute efficiency between the scintillators examined was observed for LSO:Ce, followed by LYSO:Ce. The detector optical gain (DOG) exhibited a significant variation with the increase of energy between 70 keV to 2.0 MeV. All scintillators exhibited low compatibility when combined with GaAsP (G5645) photodetector. [ABSTRACT FROM AUTHOR]

LYSO:Ce and LuYAP:Ce are single crystal non-hygroscopic scintillators of high density, high light yield and short decay time, which have been successfully used in small animal PET imagers. In the present study, the luminescence emission properties of (Lu0.9, Y0.1)2SiO5:Ce (LYSO:Ce) and (Lu0.7, Y0.3)AlO3 :Ce (LuYAP:Ce) crystals were investigated for use in x-ray medical imaging. Both crystals had dimensions of 2 × 2 × 8 mm3, with all surfaces polished. Evaluation was performed by determining the x-ray luminescence efficiency (XLE) (emitted light energy flux over incident x-ray energy flux) and the detector optical gain (DOG) (emitted light photons per incident x-ray photon) in a wide range of x-ray energies employed in mammography (22-49 kVp) and in general x-ray imaging (50-140 kVp). Measurements were performed using an experimental set-up based on a photomultiplier coupled to an integration sphere. The emission spectrum under x-ray excitation was measured using an optical grating monochromator to determine the spectral compatibility to various optical photon detectcrs incorporated in medical imaging detectors. Optical characteristics such as transmission and absorption spectra were investigated in addition to the scintillation properties. The light emission performance of the two scintillation materials studied was found adequately high for x-ray imaging. [ABSTRACT FROM AUTHOR]