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1. Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10.

Author

Orr, N., Hill, E. W., Gu, J., Govindarajan, P., Conroy, J., Grevenhof, E. M., Ducro, B. J., Arendonk, J. A. M, Knaap, J. H., Weeren, P. R., MacHugh, D. E., Ennis, S., and Brama, P. A. J.

Subjects
*OSTEOCHONDROSIS, *DUTCH people, *HORSES, *CHROMOSOMES, *DISEASES
Abstract

Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 ( BIEC2-808543; P = 5.03 × 10−7) and chromosome 10 ( BIEC2-121323; P = 2.62 × 10−7). [ABSTRACT FROM AUTHOR]

Published
2013
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