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In this study, we evaluate the soil moisture and precipitation products obtained from two reanalysis models: the National Centers for Environment Prediction (NCEP) and the European Center for Medium-Range Weather Forecasts (ECMWF). The study centers on Kuwait's semi-arid region, during the wet season (November to May) from 2008 to 2018. For the precipitation-related evaluation dataset, rain gauge records from the Kuwait Automatic Weather Observation System (KAWOS) were used, while the ground-truth soil moisture values were taken from the Climate Change Initiative (CCI-SM). Initially, to ensure CCI-SM reliability, we compare it with in-situ soil sensor measurements deployed at a desert site. The analysis revealed a maximum CCI-SM overestimation in winter, decreasing progressively throughout the year with 20% mean bias. The bias-corrected CCI-SM dataset is used for the comprehensive evaluation of the soil moisture reanalysis data. Accuracy metrics, such as mean bias (MB), correlation coefficient (R), and unbiased Root Mean Square Difference (ubRMSD), were used for this purpose. The results indicate that ERA5 consistently underestimates (~ 50% MB) soil moisture, but responds well under high soil moisture conditions. NCEP mostly overestimates soil moisture by a similar magnitude, providing even twice as high values during spring months. Mean monthly precipitation (MP) is also overestimated by NCEP, particularly during extreme episodes, yet found to be reliable enough regarding annual accumulated precipitation. ERA5 has shown strong (R ~ 0.6–0.9) predictive capabilities under both frontal and convective precipitation conditions, with ~ 3% median bias for MP, making it a promising alternative data source, particularly in regions with limited weather station coverage. [ABSTRACT FROM AUTHOR]

Surplus production models (SPMs) have a long history in fisheries ecology and are important for the assessment and management of marine species and stocks. However, the implementation, application, and usage of these models vary across regions and case studies. Good practice guidelines can streamline modelling workflows, inform the acceptance or rejection of an assessment, and facilitate the derivation of management advice from accepted assessments. This paper discusses current practices in the application of SPMs and proposes good practice guidelines for their use in stock assessment. We complement our recommendations with results from a simulation study examining the performance of an age-based operating model and a SPM assessment model under 60 scenarios with various assumptions regarding data quantity, quality, and model priors. We provide specific good practice guidelines for two widely used state-space SPMs: SPiCT and JABBA. Finally, we discuss current limitations and suggest avenues for future developments for SPMs. • Discussion of input data and priors for surplus production models. • Simulation study reveals strengths and limitations of SPMs regarding input time-series length, contrast in data, and priors. • Considerations regarding management advice derived from surplus production models. • Outline of and recommendations on future research regarding surplus production models. • Good practice guidelines for the application of surplus production models and their use to derive robust management advice. [ABSTRACT FROM AUTHOR]

In the present study, we present the aerosol optical properties and radiative forcing (RF) of the tropospheric and stratospheric smoke layers, observed by the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellite, during the extraordinary Australian biomass burning (BB) event in 2019–2020. These BB layers were studied and analyzed within the longitude range 140° E–20° W and the latitude band 20°–60° S, as they were gradually transported from the Australian banks to the South American continent. These layers were found to be trapped within the Andes circulation, staying for longer time periods in the same longitude region. The BB aerosols reached altitudes even up to 22 km amsl., and regarding their optical properties, they were found to be nearly spherical (particle linear depolarization ratio (PLDR) < 0.10) in the troposphere; while, in the stratosphere, they were more depolarizing with PLDR values reaching up to 0.20. Fine and ultrafine smoke particles were dominant in the stratosphere, according to the observed Ångström exponent, related to the backscatter coefficients obtained by the pair of wavelengths 532 and 1064 nm (Åb up to 3), in contrast to the Åb values in the troposphere (Åb < 1) indicative of the presence of coarser particles. As the aerosols fend off the source, towards North America, a slightly descending trend was observed in the tropospheric Åb values, while the stratospheric ones were lightly increased. A maximum aerosol optical depth (AOD) value of 0.54 was recorded in the lower troposphere over the fire spots, while, in the stratosphere, AOD values up to 0.29 were observed. Sharp changes of carbon monoxide (CO) and ozone (O3) concentrations were also recorded by the Copernicus Atmosphere Monitoring Service (CAMS) in various atmospheric heights over the study region, associated with fire smoke emissions. The tropospheric smoke layers were found to have a negative mean radiative effect, ranging from −12.83 W/m2 at the top of the atmosphere (TOA), to −32.22 W/m2 on the surface (SRF), while the radiative effect of the stratospheric smoke was estimated between −7.36 at the TOA to −18.51 W/m2 at the SRF. [ABSTRACT FROM AUTHOR]

Background: Intraneural ganglion cysts of the peroneal nerve are rare, and there is lack of evidence for the surgical management of this entity. We performed this study to evaluate the imaging, diagnosis, treatment and outcome of seven patients with intraneural ganglion cysts of the peroneal nerve. Materials and methods: We retrospectively studied the files of seven patients with intraneural ganglion cysts of the peroneal nerve, diagnosed and treated from 2016 to 2019. Diagnostic approach included clinical examination of the leg and foot, magnetic resonance imaging, nerve conduction studies, surgical excision of the cyst and histological examination. The mean follow-up was 2 years (range 1–3.5 years). We evaluated the time and methods for surgical treatment, and the clinical outcomes of the patients. Results: All patients presented symptoms of peripheral compression neuropathy; three patients presented with foot drop. The intraneural ganglion cysts were excised in all cases in addition to knee articular nerve branch transection to avoid cysts recurrence. Postoperatively, all patients experienced complete neurological recovery without clinical evidence of intraneural ganglion cysts recurrences. Conclusion: The treating physicians should be aware of intraneural ganglion cysts of the peroneal nerve in patients presenting with limb weakness, sensory deficits at the lateral and anterior side of the leg and foot, paresis or paralysis of the foot and ankle. MR imaging is the imaging modality of choice for a clear and accurate preoperative diagnosis to avoid misdiagnosis and wrong treatment. In case of doubt, these patients should be managed in an orthopedic oncology setting with microsurgery facilities available for complete excision of the intraneural ganglion cyst. [ABSTRACT FROM AUTHOR]

Background: The optimal technique for the displaced greater tuberosity (GT) fractures remains unclear; those in favor of arthroscopic techniques emphasize on the feasibility of arthroscopic reduction and fixation, while others report that anatomic reduction and osteosynthesis of the fracture are optimal through open surgery. Therefore, we performed this study to evaluate the clinical results of arthroscopic fixation for displaced and/or comminuted GT fractures using a bridging arthroscopic technique. Materials and methods: We studied the files of 11 patients (4 men, 7 women; mean age, 55 years; range, 28–74 years), with an isolated, displaced GT fracture treated with arthroscopic reduction and double-row suture anchor fixation technique from December 2016 to October 2018. All patients were operated at a mean time from their injury of 23 days (range, 1–85 days) using an arthroscopic technique. Any concomitant pathology that was arthroscopically identified was identified and repaired after arthroscopic fixation of the GT fracture. The mean follow-up was 12 months (range, 6–18 months). We evaluated pain using a 0–10 point visual analog scale (VAS), shoulder range of motion, fracture healing, Constant-Murley Shoulder Outcome Score, and patients' satisfaction from the operation. Results: Postoperative radiographs showed anatomic reduction without any displacement of the GT fracture in eight patients and residual displacement of < 3 mm in three patients. All patients significantly improved in VAS score from 8.4 points (range, 7–10 points) preoperatively to 0.9 points (range, 0–3 points) postoperatively. Range of motion was 153 degrees forward flexion (range, 130–170 degrees), 149 degrees abduction (range, 120–170 degrees), 42 degrees external rotation (range, 20–70), and internal rotation between T10 and L3 spinal level. The final mean Constant-Murley Shoulder Outcome Score was 85.8 points (range, 76–94 points); correlation analysis showed that the patients with the higher greater tuberosity fracture displacement had the worst postoperative score (Pearson correlation coefficient –0,85; p = 0.0009), and the patients with nonanatomic reduction had close to average score. All patients were very satisfied with the end result of the operation, even the 3 patients with residual fracture displacement. No patient experienced any postoperative complications. Conclusions: Arthroscopic reduction and fixation of displaced GT fractures is a feasible minimally invasive procedure for optimal fracture healing and patients satisfaction. [ABSTRACT FROM AUTHOR]

We investigate the temporal evolution of the planetary boundary-layer (PBL) height over the basin of Athens, Greece, during a 6-year period (2011–2016), using data from a Raman lidar system. The range-corrected lidar signals are selected around local noon (1200 UTC) and midnight (0000 UTC), for a total of 332 cases: 165 days and 167 nights. In this dataset, the extended-Kalman filtering technique is applied and tested for the determination of the PBL height. Several well-established techniques for the PBL height estimation based on lidar data are also tested for a total of 35 cases. The lidar-derived PBL heights are compared to those derived from radiosonde data. The mean PBL height over Athens is found to be 1617 ± 324 m at 1200 UTC and 892 ± 130 m at 0000 UTC for the period examined, while the mean PBL-height growth rate is found to be 170 ± 64 m h−1 and 90 ± 17 m h−1 during daytime and night-time, respectively. [ABSTRACT FROM AUTHOR]

Objective: Rare co-existance of disease or pathology. Background: Luxatio erecta humeri (LEH) is a rare injury present in only 0.5% of shoulder dislocations. Much of the relevant literature is focused on the initial management and proper reduction techniques, although the prevalence of associated injuries can reach 80%. A case of LEH associated with greater tuberosity (GT) fracture and rotator cuff (RC) tear in a young laborer managed with closed reduction and arthroscopic repair of the labrum and rotator cuff is presented. Case Report: A 28-year-old man presented to our hospital with severe pain in his right shoulder after a high-impact motor vehicle accident. Standard anteroposterior radiographs revealed an inferior dislocation (LEH) of the right shoulder and a fracture of the GT. The patient was initially managed with closed reduction under mild intravenous sedation, using a 2-step maneuver followed by arthroscopic evaluation of the joint the next day. During arthroscopic evaluation, an anterior-inferior Bankart lesion, impaction of the humeral head with a minimal displaced GT fracture, and a partial RC tear were identified and successfully treated arthroscopically. The patient had immobilization in a simple sling for 6 weeks and he followed a standard 3-month physiotherapy protocol for rotator cuff, finally regaining almost normal range of shoulder motion at 1 year. Conclusions: Although very good results of non-operative treatment of LEH have been reported in the literature, the coexistence of intra-articular lesions such as labral and rotator cuff tears makes arthroscopic repair an attractive alternative in individual cases. [ABSTRACT FROM AUTHOR]

A new method, called ElEx (elastic extinction), is proposed for the estimation of extinction coefficient lidar profiles using only the information provided by the elastic and polarization channels of a lidar system. The method is applicable to lidar measurements both during daytime and nighttime under well-defined aerosol mixtures. ElEx uses the particle backscatter profiles at 532 nm and the vertically resolved particle linear depolarization ratio measurements at the same wavelength. The particle linear depolarization ratio and the lidar ratio values of pure aerosol types are also taken from literature. The total extinction profile is then estimated and compared well with Raman retrievals. In this study, ElEx was applied in an aerosol mixture of marine and dust particles at Finokalia station during the CHARADMExp campaign. Any difference between ElEx and Raman extinction profiles indicates that the nondust component could be probably attributed to polluted marine or polluted continental aerosols. Comparison with sun photometer aerosol optical depth observations is performed as well during daytime. Differences in the total aerosol optical depth are varying between 1.2 % and 72 %, and these differences are attributed to the limited ability of the lidar to correctly represent the aerosol optical properties in the near range due to the overlap problem. [ABSTRACT FROM AUTHOR]

High communicational standards have been set for the 5G mobile networks. Therefore, it is of great importance that technological solutions that include all the significant features, such as the high coverage and capacity and low round-trip delays, are adopted for the next generation of mobile networks. Except for their technical efficiency, these technologies should be profitable for providers as well. As a result, the need for limiting the costs spent for the development of these technologies emerges. In this papers, four models two for each one of the two solutions for 5G networks are developed, namely the Multiple Input Multiple Output (MIMO) and the Distributed Antenna System. The architectural models assumed for the techno-economic analyses are presented. The mathematical models for both technologies are developed. Experiments are conducted using prices of the Greek market and also Sensitivity Analysis (SA) is used to pinpoint, which cost parameters are the most expensive ones and therefore it is likely that they discourage providers to invest in them. To our knowledge there are not many studies comparing and contrasting these technologies and there is no SA for MIMO. Therefore, it is considered that research for these models is of vital importance for the next generation of mobile communication networks, as they are foundation stonesfor the formation of 5G. [ABSTRACT FROM AUTHOR]

Introduction: In upper brachial plexus injuries (C5-C6-C7), selective nerve transfers appear as a favourable technique. For this purpose, transfer of an ulnar nerve fascicle to the biceps motor branch (Oberlin's procedure) is often used. In this paper we present our modified Oberlin technique, as well as a comparison of this method with the classic Oberlin procedure.Materials and Methods: We present two groups of patients that where operated by two different surgeons. The first group, consisting of 16 patients was treated with the classic Oberlin procedure. The second group included 5 patients treated with a modified Oberlin procedure, where two fascicles from the ulnar nerve were transferred to both the motor branch of the biceps and the motor branch of the brachialis muscles.Results: In the last follow-up of the 16 patients from the first group with the classic Oberlin procedure, 15 patients (93.75%) had Medical Research Council (MRC) grade of biceps strength 4 and 1 patient (6.25%) had MRC grade 3, whereas in the group where the modified Oberlin procedure was used the muscle strength was very durable with 4 out of 5 the patients reached MRC grade of 4+ and one MRC grade of 4, and with a mean elbow strength at 5.4 kg (3-8 kg). No sensitivity or motor problems were encountered on the ulnar territories for both groups.Conclusion: With the modified Oberlin technique, the median nerve is reserved and both elbow flexors are innervated. The results of this technique compare favourably with those of other methods. Thus, we propose using the double fascicle transfer from the ulnar nerve to both elbow flexors in order to restore a strong elbow flexion in patients with upper brachial plexus injuries. [ABSTRACT FROM AUTHOR]

Benign peripheral nerve tumors encompass a wide range of neoplasms and non-neoplastic tumor like lesions. Some of these lesions if not encountered in the setting of genetic syndromes, are occurring sporadically. The principles of oncology should be respectfully followed in every step of diagnostic approach and surgical management. Albeit, classified as benign, some of them do have different level of malignant potential, thus the treating physicians should be aware of that to avoid possible pitfalls with devastating outcomes. This article reviews the most common benign peripheral nerve tumors discussing the clinicopathological findings, imaging appearance and the current trend in their approach. [ABSTRACT FROM AUTHOR]

In this study we estimate the particle extinction profiles at Finokalia, Crete, using only the information provided by the elastic and polarization channels of a PollyXT lidar system. Most of the time Finokalia site is affected by only two aerosol types, i.e. marine and dust particles. These two aerosol types, having different optical properties, permit the separation of aerosol mixture. The proposed method uses the particle backscatter profiles at 532 nm and the vertically resolved particle linear depolarization ratio measurements at the same wavelength. The particle linear depolarization ratio and the lidar ratio values of pure aerosol types are taken from literature. The total extinction profile is then estimated and compared well with Raman retrievals. Any difference between the proposed methodology and Raman extinction profiles indicates that the non-dust component could be probably attributed to polluted marine or polluted continental aerosols. Comparison with sun-photometric aerosol optical depth observations is performed as well during daytime with reasonable differences between the two instruments. Differences in the total aerosol optical depth is attributed to the limited ability of the lidar to correctly represent the aerosol optical properties in the near range due to overlap problem. [ABSTRACT FROM AUTHOR]

The lateral arm flap (LAF) is a popular flap transfer, which can be applied in many procedures. It was first described in 1982, and till then, even more clinical applications are suggested. It can be used as a free fasciocutaneous or fascial flap to cover small- to medium-sized soft tissue defects in head and neck but also in upper and lower extremity reconstruction, or as an osteocutaneous flap when vascularized bone graft is needed. We present the indications and contraindications, the advantages and disadvantages, as well as the step-by-step technique of harvesting a fasciocutaneous and an osteocutaneous flap and its complications. We conclude that the LAF is a reliable and versatile tool for reconstructive surgery, due to its anatomical characteristics and the low complication rate. [ABSTRACT FROM AUTHOR]

Subtrochanteric fractures can result from high-energy trauma in young patients or from a fall or minor trauma in the elderly. Intramedullary nails are currently the most commonly used implants for the stabilization of these fractures. However, the anesthetic procedure for the patients, the surgical reduction and osteosynthesis for the fractures are challenging. The anesthetic management of orthopedic trauma patients should be based upon various parameters that must be evaluated before the implementation of any anesthetic technique. Surgery- and patient-related characteristics and possible comorbidities must be considered during the pre-anesthetic evaluation. Adequate fracture reduction and proper nail entry point are critical. Understanding of the deforming forces acting on various fracture patterns and knowledge of surgical reduction techniques are essential in obtaining successful outcomes. This article discusses the intraoperative reduction techniques for subtrochanteric fractures in adults and summarizes tips and tricks that the readers may find useful and educative. [ABSTRACT FROM AUTHOR]

Highlights • Citizen science based data enables higher temporal and spatial resolution. • Citizen science using focus groups provides highly useful cost-efficient monitoring. • Fish indicators for system health can be generated from this type of data. • Through capacity building, fishermen became ambassadors for responsible fishing practices and healthy ecosystems. Abstract In response to repeated complaints from recreational and commercial coastal fishermen about declining fishing opportunities in inner Danish waters, focus was directed to inshore fish stocks. However, without data targeting inshore areas, it was not possible to investigate potential changes in fish distribution or abundances, or their causes. As a first step, a voluntary catch registration system was initiated in 2002, in collaboration with locally organized recreational fishermen. Using citizen science as a methodology, scientists and the fishermen developed a protocol for data collection, which the fishermen then implemented. The aim was to establish regular monitoring of fish catches from gill net and fyke net fisheries in coastal waters around Denmark in order to provide data that could inform management. After three years, during which time recreational fishermen could use their own gear and fish where they normally fished, the data was evaluated. As a result, the fishing method was switched in 2005 to fixed gears and fixed positions, to enable comparison between areas, years and season. The project has been very successful in recruiting highly motivated fishermen, who register their entire catch regularly. The time-series of data spans more than a decade and covers over 16,000 instances of fishing. The data from this project are now being used to create coastal fish indicators for managers to assess environmental status at a regional scale. Here we present an analysis of a subset of the data on one species, the European flounder (Platichthys flesus), to illustrate how the spatial and seasonal coverage can be utilized further for investigation of coastal ecosystems and to inform management. [ABSTRACT FROM AUTHOR]

There is global interest in providing scientific advice on optimal harvesting of all commercially exploited fish stocks. Nevertheless, many commercially important stocks lack analytical assessments. Therefore, we evaluate a data-moderate stock assessment method: the stochastic surplus production model in continuous time (SPiCT). The method was applied to two Namibian stocks: (i) the data-rich Cape monkfish Lophius vomerinus, where results are compared to a new data-rich assessment using a state-space assessment model (SAM); and (ii) the data-moderate west coast sole Austroglossus microlepis, which is an important bycatch species in the Cape monkfish fishery, but currently unassessed. The information available to the data-moderate assessment is total commercial catch, commercial catch per unit effort (CPUE), and survey CPUE. SPiCT and SAM gave largely consistent estimates of relative fishing mortality (F/FMSY) and relative exploitable biomass (B/BMSY) for the Cape monkfish stock, although with some discrepancies. Differences in the biomass estimates between the two assessments suggest that further investigation is required to understand the cause, and that some caution is necessary when considering the biomass of the stock. SPiCT shows that the west coast sole may be overexploited, although the confidence bounds were too wide for a firm conclusion. Similarity in the estimates of F/FMSY for Cape monkfish in recent years, using SPiCT relative to SAM, likewise indicates the suitability of SPiCT for managing west coast sole. [ABSTRACT FROM AUTHOR]

Paget's disease of bone, osteitis deformans or chronic inflammation of bone is a chronic non-metabolic bone disorder that typically begins with excessive bone resorption followed by an increase in bone formation. Isolated monostotic Paget's disease of the radius is extremely rare, often mimicking various entities. A high index of suspicion is required supported with imaging studies for the correct diagnosis. Long-term follow-up is mandatory in these patients in order to identify and treat any subsequent recurrence or secondary malignancy. This article describes a 56-year-old man who presented with progressive deformity of the right radius previously misdiagnosed as giant cell tumor. Definite diagnosis was obtained with bone biopsy supported by magnetic resonance imaging and bone scan. [ABSTRACT FROM AUTHOR]

A rare event of mixed biomass-burning and polluted dust aerosols was observed over Athens, Greece (37.9° N, 23.6° E), during 21–26 May 2014. This event was studied using a synergy of a 6-wavelength elastic-Raman-depolarization lidar measurements, a CIMEL sun photometer, and in situ instrumentation. The FLEXPART dispersion model was used to identify the aerosol sources and quantify the contribution of dust and black carbon particles to the mass concentration. The identified air masses were found to originate from Kazakhstan and Saharan deserts, under a rare atmospheric pressure system. The lidar ratio (LR) values retrieved from the Raman lidar ranged within 25–89 sr (355 nm) and 35–70 sr (532 nm). The particle linear depolarization ratio (δaer) ranged from 7 to 28% (532 nm), indicating mixing of dust with biomass-burning particles. The aerosol optical depth (AOD) values derived from the lidar ranged from 0.09–0.43 (355 nm) to 0.07–0.25 (532 nm). An inversion algorithm was used to derive the mean aerosol microphysical properties (mean effective radius (reff), single scattering albedo (SSA), and mean complex refractive index (m)) inside selected atmospheric layers. We found that reff was 0.12–0.51 (±0.04) µm, SSA was 0.94–0.98 (±0.19) (at 532 nm), while m ranged between 1.39 (±0.05) + 0.002 (±0.001)i and 1.63 (±0.05) + 0.008 (±0.004)i. The polarization lidar photometer networking (POLIPHON) algorithm was used to estimate the vertical profile of the mass concentration for the dust and non-dust components. A mean mass concentration of 15 ± 5 μg m−3 and 80 ± 29 μg m−3 for smoke and dust was estimated for selected days, respectively. Finally, the retrieved aerosol microphysical properties were compared with column-integrated sun photometer CIMEL data with good agreement. [ABSTRACT FROM AUTHOR]

The mathematical formulation for the optical setup of a typical EARLINET lidar system is given here. The equations describing a lidar system from the emitted laser beam to the projection of the telescope aperture on the final receiving unit (i.e., photomultiplier or photodiode) are presented, based on paraxial approximation and geometric optics approach. The receiving optical setup includes a telescope, a collimating lens, an interference filter and the ensemble objective eyepiece. The set of the derived equations interconnects major parameters of the optical components (e.g., focal lengths, diameters, angles of incidence), revealing their association with the distance of full overlap of the system. These equations may used complementarily with an optical design software, for the preliminary design of a system or can be used as a quick check up tool of an existing lidar system. The evaluation of the formulation on a real system is performed with ray-tracing simulations, revealing an overall good performance with relative differences of the order of 5% mainly attributed to the limitations of the thin lens approximation. [ABSTRACT FROM AUTHOR]

Posterior shoulder fracture-dislocation is a rare injury accounting for approximately 0.9 % of shoulder fracture-dislocations. Impression fractures of the articular surface of the humeral head, followed by humeral neck fractures and fractures of the lesser and grater tuberosity, are the more common associated fractures. Multiple mechanisms have been implicated in the etiology of this traumatic entity most commonly resulting from forced muscle contraction as in epileptic seizures, electric shock or electroconvulsive therapy, major trauma such as motor vehicle accidents or other injuries involving axial loading of the arm, in an adducted, flexed and internally rotated position. Despite its' scarce appearance in daily clinical practice, posterior shoulder dislocation is of significant diagnostic and therapeutic interest because of its predilection for age groups of high functional demands (35-55 years old), in addition to high incidence of missed initial diagnosis ranging up to 79 % in some studies. Several treatment options have also been proposed to address this type of injury, ranging from non-surgical methods to humeral head reconstruction procedures or arthroplasty with no clear consensus over definitive treatment guidelines, reflecting the complexity of this injury in addition to the limited evidence provided by the literature. To enhance the literature, this article aims to present the current concepts for the diagnosis, evaluation and treatment of the patients with posterior fracture-dislocation shoulder, and to present a treatment algorithm based on the literature review and our own experience. [ABSTRACT FROM AUTHOR]

Many methods exist to assess the fishing status of data-limited stocks; however, little is known about the accuracy or the uncertainty of such assessments. Here we evaluate a new size-based data-limited stock assessment method by applying it to well-assessed, data-rich fish stocks treated as data-limited. Particular emphasis is put on providing uncertainty estimates of the data-limited assessment. We assess four cod stocks in the North-East Atlantic and compare our estimates of stock status (F/Fmsy) with the official assessments. The estimated stock status of all four cod stocks followed the established stock assessments remarkably well and the official assessments fell well within the uncertainty bounds. The estimation of spawning stock biomass followed the same trends as the official assessment, but not the same levels. We conclude that the data-limited assessment method can be used for stock assessment and that the uncertainty estimates are reliable. Further work is needed to quantify the spawning biomass of the stock. [ABSTRACT FROM AUTHOR]

In this paper we validate the Lidar-Radiometer Inversion Code (LIRIC) retrievals of the aerosol concentration in the fine mode, using the airborne aerosol chemical composition dataset obtained over the Greater Athens Area (GAA) in Greece, during the ACEMED campaign. The study focuses on the 2nd of September 2011, when a long-range transported smoke layer was observed in the free troposphere over Greece, in the height range from 2 to 3 km. CIMEL sun-photometric measurements revealed high AOD (~ 0.4 at 532 nm) and Ångström exponent values (~ 1.7 at 440/870 nm), in agreement with coincident ground-based lidar observations. Airborne chemical composition measurements performed over the GAA, revealed increased CO volume concentration (~ 110 ppbv), with 57% sulphate dominance in the PM 1 fraction. For this case, we compare LIRIC retrievals of the aerosol concentration in the fine mode with the airborne Aerosol Mass Spectrometer (AMS) and Passive Cavity Aerosol Spectrometer Probe (PCASP) measurements. Our analysis shows that the remote sensing retrievals are in a good agreement with the measured airborne in-situ data from 2 to 4 km. The discrepancies observed between LIRIC and airborne measurements at the lower troposphere (below 2 km), could be explained by the spatial and temporal variability of the aerosol load within the area where the airborne data were averaged along with the different time windows of the retrievals. [ABSTRACT FROM AUTHOR]

The mathematical formulation for the optical setup of a typical EARLINET lidar system is given here. The equations describing a lidar system from the emitted laser beam to its projection on the final receiving unit are revealed, based on paraxial approximation and geometric optics approach. The evaluation of the formulation is performed with ray tracing simulations, revealing an overall good performance with relative differences of the order of 5% mainly attributed to aberrations that are not taken into account in paraxial approximation. [ABSTRACT FROM AUTHOR]

The management of complex tibial plateau fractures is ever evolving. The severity of the injury to the surrounding soft tissues influences the timing and the method of fixation. Minimal invasive techniques continue to dominate our philosophy of reduction and reconstruction whereas augmentation of depressed intra-articular fragments remains an accepted strategy to maintain reduction and prevent secondary collapse. Locking plates, conventional plates and fine wire fixators all have been used successfully with satisfactory outcomes. In this article we report on the latest advances made in the management of these complex injuries. [ABSTRACT FROM AUTHOR]

For stocks which are considered “data-poor” no knowledge exist about growth, mortality or recruitment. The only available information is from catches. Here we examine the ability to assess the level of exploitation of a data-poor stock based only on information of the size of individuals in catches. The model is a formulation of the classic Beverton–Holt theory in terms of size where stock parameters describing growth, natural mortality, recruitment, etc. are determined from life-history invariants. A simulation study was used to compare the reliability of assessments performed under different information availability scenarios, from data-limited, where none of the parameters are known beforehand, to different degrees of information availability cases where one or more parameters are known. If no parameters are known it is possible to correctly assess whether the fishing mortality is below F msy in more than 60% of the cases, and almost always correctly assess whether a stock is subject to overfishing. Adding information about age, i.e., assuming that growth rate and asymptotic size are known, does not improve the estimation. Only knowledge of the ratio between mortality and growth led to a considerable improvement in the assessment. Overall, the simulation study demonstrates that it may be possible to classify a data-poor stock as undergoing over- or under-fishing, while the exact status, i.e., how much the fishing mortality is above or below F msy , can only be assessed with a substantial uncertainty. Limitations of the approach are discussed. [ABSTRACT FROM AUTHOR]

Arteriovenous prosthetic grafts are used in hemodialysis. Stenosis in the venous anastomosis is the main cause of occlusion and the role of local hemodynamics in this is considered significant. A new spiral graft design has been proposed to stabilize the flow phenomena in the host vein. Cross-flow vortical structures in the outflow of this graft were compared with those from a control device. Both grafts were integrated in identical in-house ultrasound-compatible flow phantoms with realistic surgical configurations. Constant flow rates were applied. In-plane 2-D velocity and vorticity mapping was developed using a vector Doppler technique. One or two vortices were detected for the spiral graft and two to four for the control, along with reduced stagnation points for the former. The in-plane peak velocity and circulation were calculated and found to be greater for the spiral device, implying increased in-plane mixing, which is believed to inhibit thrombosis and neo-intimal hyperplasia. [ABSTRACT FROM AUTHOR]

Background: Hip fractures are an increasingly common consequence of falls in older people that are associated with a high risk of death and reduced function. The vast majority of intertrochanteric fractures require surgical treatment to withstand early mobilization and weight bearing, which prevents complications due to prolonged bed rest and aids in fracture healing. Methods: This study is compromised by two parts, the experimental study and the clinical part. In the first part, a standard 130° nail will be used with the appropriate lag screw(s) and dynamic distal locking in synthetic osteoporotic femurs and the transmission of forces in the proximal femur, measured by a cortical surface-strain distribution, will be evaluated using digital image correlation. Finite element parametric models of the bone, the nails and their interface will be also developed. Finite element computations of surface strains in implanted femurs, after being validated against biomechanical testing measurements, will be used to assist the comparison of the nails by deriving important data on the developed stress and strain fields, which cannot be measured through biomechanical testing. In the other part, will set up a prospective, randomized, comparative clinical study among the Gamma3 and IT cephalomedullary nailing, in order to investigate if there are any statistical important differences in the main radiological measurements and functional status in closed unstable intertrochanteric fractures (A21-3) in patients aged over 70 years old at the 24-week follow-up evaluation using patient reported disease-specific outcomes. Discussion: This study will be the first to compare clinical, radiological and biomechanical measurements of the two different cephalomedullary nails. Our main hypothesis is that the IT nail would provide better radiological outcome and probably better clinical results than the Gama3 nail. Clinical trial registration International Standard Randomized Controlled Trial Number (ISRCTN): https://doi.org/10.1186/ISRCTN15588442, registered on 19/4/2022. [ABSTRACT FROM AUTHOR]

Generation of induced pluripotent stem cells from specialized cell types provides an excellent model to study how cells maintain their stability, and how they can change identity, especially in the context of disease. Previous studies have shown that chromatin safeguards cell identity by acting as a barrier to reprogramming. We investigated mechanisms by which the histone macroH2A variants inhibit reprogramming and discovered that they work as gate keepers of the mesenchymal cell state by blocking epithelial transition, a step required for reprogramming of mouse fibroblasts. More specifically, we found that individual macroH2A variants regulate the expression of defined sets of genes, whose overall function is to stabilize the mesenchymal gene expression program, thus resisting reprogramming. We identified a novel gene network (MSCN, mesenchymal network) composed of 63 macroH2A-regulated genes related to extracellular matrix, cell membrane, signaling and the transcriptional regulators Id2 and Snai2, all of which function as guardians of the mesenchymal phenotype. ChIP-seq and KD experiments revealed a macroH2A variant-specific combinatorial targeting of the genes reconstructing the MSCN, thus generating robustness in gene expression programs to resist cellular reprogramming. [ABSTRACT FROM AUTHOR]

Background: Apremilast is a new immunomodulatory drug, a smallmolecule inhibitor of PDE4, which down-regulates the expression of multiple pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin 17, interleukin 23. Main observations:We describe a case of a 54-year-oldman with erythroderma in the course of psoriasis (PASI=49), with contraindications to other psoriasis therapies, in whom total clearance of skin lesions was achieved by day 20 after therapy with apremilast at a dose of 30 mg bid (ΔPASI = 100). The patient had a history of prior use of cyclosporine, methotrexate and adalimumab. His comorbidities included obesity, fatty liver and hypercholesterolemia. Conclusion: In this case of erythroderma in the course of psoriasis apremilast led to total clearance of all cutaneous lesions. [ABSTRACT FROM AUTHOR]

Abstract: Prosthetic grafts are used for the treatment of peripheral arterial disease. Re-stenosis in the distal anastomosis of these grafts is a common reason for graft occlusion. The role of local hemodynamics in development of neo-intimal hyperplasia is well known. A new graft design has been proposed for the induction of optimized spiral flow in the host vessel. The secondary flow motions induced by this graft were compared with those of a control device. Both types of grafts were connected with vessel mimic and positioned in ultrasound flow phantoms with identical geometry. Constant flow rates were applied. Data collected in the cross-sectional view distal from the graft outflow and dual-beam vector Doppler was applied to create 2-D velocity maps. A single-spiral flow pattern was found for the flow-modified graft, and double or triple spirals for the control graft. In-plane maximum velocity was greater for the flow-modified graft than for the control device. [Copyright &y& Elsevier]

Abstract: Biceps and triceps tendon ruptures are rather uncommon injuries and are most commonly diagnosed clinically. Magnetic resonance imaging can help the clinician to differentiate an incomplete tear and define any degeneration of the tendon. Surgical anatomical repair is typically performed in acute complete ruptures whereas nonoperative treatment can be used for partial ruptures, as well as for patients unfit for surgery. Single incision techniques are associated with a higher rate of nerve injuries, while double incision repairs have a higher prevalence of heterotopic ossification. Although various fixation methods have been applied including bone tunnels, interference screws, suture anchors, cortical button fixation, the current evidence does not support the superiority of one method over the other. A well-planned postoperative rehabilitation programme is essential for a good final outcome. As better fixation devices are being used, more aggressive rehabilitation programmes have been applied. Epidemiology, clinical evaluation, diagnosis, surgical and conservative management of these injuries are presented in this review along with the authors’ preferred technique for the anatomical repair of acute complete ruptures. [Copyright &y& Elsevier]

A strong dust event over Abastumani, Georgia, during May 2009 was studied using light detection and ranging (lidar), satellite and sun photometric measurements. High aerosol optical depth (AOD) values (0.45–0.57) at 500 nm were measured over the closest Aerosol Robotic Network (AERONET) site (Erdemli, Turkey), whereas over Georgia, the AOD measured by the Moderate Resolution Imaging Spectroradiometer (MODIS) was about 0.9 at 550 nm. The AERONET data analysis showed a mean aerosol effective radius of about 2.5 μm, whereas the mean value of the Ångström exponent (α) (wavelength pair 440/870 nm) was smaller than 1, indicating the dominance of large aerosols. The aerosol lidar over Abastumani showed the existence of a strong particle load from the near ground up to a height of 3.5 km. The BSC-DREAM8b forecast model showed that the dust aerosols travelled from the Saharan and the Arabic deserts to the studied area, even reaching southern Russia, covering a total distance of about 5500 km, in the height region from about 2 to 11.5 km. [ABSTRACT FROM AUTHOR]

This study investigated the hypothesis that acetyl-L-carnitine (ALCAR) could have a significant effect on nerve regeneration after end-to-side neurorrhaphy. The ability of the ALCAR to enhance nerve regeneration in combination with various types of donor nerve injury distal to the coaptation site was also determined. Twenty-five Sprague-Dawley rats were randomized to five groups of five animals each, in which three different types of donor injury (crush, ligation, and transection injury) distal to the coaptation site were executed (groups C, D, and E, respectively). Animals in group A (placebo) and group B underwent a standard end-to-side neurorrhaphy. Animals from groups B to E received a daily intraperitoneal injection of 50 mg/kg/d of ALCAR, and a placebo was injected in place of ALCAR in animals in group A. Administration of acetyl-L-carnitine alone did not prove to be a significant stimulus for regeneration, as concluded after comparison among the two noninjury models of the donor nerve (groups A and B). Indeed, the combination of an injury model of the donor nerve (crush injury) with administration of acetyl-L-carnitine proved to be a significantly more potent stimulus for regeneration than the control (placebo) group, as measured by behavioral, muscle morphometric, electrophysiological, and histomorphometric studies. [ABSTRACT FROM AUTHOR]

In end-to-side neurorrhaphy, "noninjury" models of the donor nerve do not seem to offer worthwhile functional outcomes. The role of donor nerve injury distal to the coaptation site remains unclear. End-to-side neurorrhaphy was studied in a rat model in which the proximal stump of the transected musculocutaneous nerve was sutured to the median nerve by end-to-side coaptation. Twenty Sprague-Dawley rats were randomized to four groups of five animals each, in which three different types of donor injury (crush, ligation, or transection injury) distal to the coaptation site were executed; findings were compared with a similar end-to-side model without donor nerve injury (control). Behavioral analysis, electrophysiological studies, muscle morphometric studies, and nerve fibers counts showed no significant differences among groups. However, there was a significant difference regarding mean myelin area ( P?=?0.0362) and mean fiber diameter ( P?=?0.0159) for the crush injury group as compared with the control group. No significant differences were found among the other groups. These data suggest that donor crush injury distal to the coaptation site may increase the rate of myelin formation in regenerating axons across an end-to-side model; however, at 4 weeks of follow-up, there was no significant behavioral or functional significance in this treatment group. [ABSTRACT FROM AUTHOR]

Summary: Objectives: In this retrospective review, the methods and outcomes in 96 children (98 extremities) with obstetric brachial plexus palsy who underwent primary reconstruction and/or palliative surgery for shoulder function were analysed. Methods: Thirty cases underwent primary reconstruction alone, 37 underwent both primary and secondary procedures, and 31 late cases underwent only palliative surgery. The mean follow-up period was 6.7 years. Results: The mean shoulder abduction increased from 48°±32° preoperatively to 123°±35° postoperatively (average gain 75°); the mean active external rotation with the arm at the side increased from −19°±17° to 62°±21° (mean gain 81°); and the mean aggregate Mallet score improved from 8.8 points to 20.9 points, respectively. Conclusions: Reconstruction of both axillary and suprascapular nerves yielded improved outcomes of shoulder abduction and external rotation. Early plexus reconstruction (≤3 months) offered the best functional results and reduced the need for secondary reconstructions. A marked improvement was observed after palliative surgery irrespective of prior nerve reconstruction. Rerouting of latissimus dorsi and/or teres major tendons, combined with extra-articular musculotendinous lengthening, significantly improved global shoulder function. [Copyright &y& Elsevier]

Abstract: Experiments were conducted on the maximum and terminal penetration depths of fountains of light fluid, issuing vertically downwards into quiescent denser fluid. Fresh water jets into saltwater, and hot water jets into fresh cold water were investigated. The source Richardson numbers extended from 0.01 (jets) to 1 (plumes). Circular and three other different shape nozzles have been employed. The normalized penetration depth is constant for jets, while it decays exponentially in plumes. Numerical evaluation of the penetration depth has indicated the need for reevaluation of the entrainment coefficient, in negatively buoyant jets. [Copyright &y& Elsevier]

A meta-analysis was conducted to examine the impact of recreational ecstasy use on short-term memory (STM), long-term memory (LTM), verbal and visual memory. We located 26 studies containing memory data for ecstasy and non-ecstasy users from which effect sizes could be derived. The analyses provided measures of STM and LTM in 610 and 439 ecstasy users and revealed moderate-to-large effect sizes (Cohen's d) of d = -0.63 and d = -0.87, respectively. The difference between STM versus LTM was non-significant. The effect size for verbal memory was large (d = -1.00) and significantly larger than the small effect size for visual memory (d = -0.27). Indeed, our analyses indicate that visual memory may be affected more by concurrent cannabis use. Finally, we found that the total lifetime number of ecstasy tablets consumed did not significantly predict memory performance. Copyright © 2007 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Pavement surface texture greatly contributes to tire-pavement skid resistance. Pavement surface irregularities are continuous from pavement macrotexture to pavement microtexture. Their pattern is also roughly repetitive. This existence of self-similarity encourages an attempt to approximate the pavement surface texture with fractals in order to take advantages of fractal modeling. The mathematical background is based on C[sup 0] and C[sup 1] fractal interpolation curves. Through this approximation, the procedure of pavement surface wear is evaluated, in respect to its effect to skid resistance values. Fractal potential is simultaneously tested in representing pavement surface contamination. A qualitative relationship between the skid resistance values of characteristic pavement surface texture profiles and the fractal dimension of their interpolation function is recognized. The whole attempt yields encouraging results, although it is apparent that further research is required. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study was to correlate athletic performance with both lung function and diet. Design: Open, uncontrolled trial. Materials and Methods: Sixty-eight swimmers (28 females and 40 males), 9-15 years old, were registered for the study. The average age was 11.75 years, the average height was 151.65 cm and the average weight was 42.88 kg. Every swimmer completed a questionnaire which included details about eating habits and performances in the 100 m freestyle and backstroke. They were submitted to spirometry tests and diffusion capacity measurements (with a simple inspiration of carbon monoxide). All swimmers had three spirometry tests. The best one was recorded and compared to the expected values. Results: The average diffusing capacity was 29.07% higher than expected and the average forced expiratory volume in the first second was 4.21% higher than expected. Swimmers who consumed 5.7 meals per week based on meat and 4.43 meals per week based on vegetables performed better than swimmers who consumed 4 meals per week based on vegetables and 3.35 meals per week based on meat (p < 0.001). Swimmers with better lung function performed significantly more impressively in both styles (p < 0.001). Based on multiple logistic regression analysis we found equations that correlate swimming performance with age, height, lung function and diet. Conclusions: Swimmers' performance is related to lung function and diet. Diffusing capacity and dynamic volume measurement are adequate methods of evaluating lung function. [ABSTRACT FROM AUTHOR]

In this study we present the role of the Planetary Boundary Layer Height (PBLH) on the air pollutant concentrations measured at an urban background station at the megacity of Athens, Greece, an area characterized by complex topography. For this purpose, we utilized in situ measurements of aerosol number concentrations at different size bins (10–200 nm) N 10-200nm , (200–550 nm) N 200-550nm , equivalent Black Carbon (eBC), and wind speed data, for the period of May – July 2020. According to our analysis, both horizontal transport and vertical mixing and dispersion of air pollutants play a critical role in air quality. More precisely, PBLH is negatively correlated with aerosol concentration. The increase in the height of the Planetary Boundary Layer (PBL) favors a reduction in aerosol concentration, which, to some extent, compensates for the increase in aerosol load due to emission sources and horizontal transport from the city center. The horizontal advection process is related to the PBLH, since a deep PBL drives the advection, while a shallow PBL is characterized by weak horizontal wind velocities. On the other hand, under stagnant air mass conditions, when the PBL shrinks, the concentrations of air pollutants increase. On average, a 25% increase in the PBLH results in a 15% reduction in aerosol concentration, whereas a 15% reduction in the PBLH may result in a 10% increase in aerosol concentrations. Overall, N 10-200nm particle concentrations increases, when air masses arrive from the S-NW sector (city center) due to traffic and vehicle emissions, while transport of continental pollution mixed with local and regional emissions along the Balkans-Aegean Sea axis, is originating from the NE axis under high wind speeds. The latter is more clearly recognized from aged aerosol components such as sulphate. Whereas, the N 200-550nm and eBC showed increased concentration load under stagnant air mass conditions, independently of the wind direction. [Display omitted] • Horizontal transport, vertical mixing and dispersion of air pollutants play a critical role in air quality. • PBLH is negatively correlated with aerosol concentration. • The increase in the height of the PBL favors a reduction in aerosol concentration, • Under stagnant air mass conditions, when the PBL shrinks, the concentrations of air pollutants increase. [ABSTRACT FROM AUTHOR]

Introduction: The aim of this study was to compare the results of single versus double row (TEO) in massive tears of the posterosuperior rotator cuff in patients older than 70 years old. Methods: Between October 2019 and July 2022, 46 patients, older than 70 years old, were operated on, in two centers, by one surgeon (FM), in one center, we performed a single-row repair, while in the other a double row, transosseous equivalent. Patients were paired by age and gender. All patients were studied with a preoperative MRI along with preoperative age and gender adjusted constant score. Postoperative patients were evaluated at the end of the FU. Mean time of FU for single row was 3.2 years (2–4.1) and for TOE was 3.5 years (2.4–3). Mean age for SR patients was 71.15 years (70–82) and for TOE was 74.8 years (70–81). We were able to evaluate 20 pairs of patients (15 pairs of females and five pairs of males). Results: CS differed in both groups of patients. Patients operated on with TOE had a better, but non-significant CS 81.3 (TOE) versus 75.7 (SR) p > 0.05. The patients operated own with TOE showed statistically significant better arm abduction strength than patients operated on with SR (p < 0.05). There was a trend for patients operated on with TOE to have a better ROM and less pain. Discussion: The results of our work show that patients older than 70 years old, with repairable RCT operated on with a transosseous equivalent, have a trend to have a better CS and a significantly better strength than patients operated on with SR. [ABSTRACT FROM AUTHOR]

We report on a long-lasting (10 days) Saharan dust event affecting large sections of South-Eastern Europe by using a synergy of lidar, satellite, in-situ observations and model simulations over Athens, Greece. The dust measurements (11–20 May 2020), performed during the confinement period due to the COVID-19 pandemic, revealed interesting features of the aerosol dust properties in the absence of important air pollution sources over the European continent. During the event, moderate aerosol optical depth (AOD) values (0.3–0.4) were observed inside the dust layer by the ground-based lidar measurements (at 532 nm). Vertical profiles of the lidar ratio and the particle linear depolarization ratio (at 355 nm) showed mean layer values of the order of 47 ± 9 sr and 28 ± 5%, respectively, revealing the coarse non-spherical mode of the probed plume. The values reported here are very close to pure dust measurements performed during dedicated campaigns in the African continent. By utilizing Libradtran simulations for two scenarios (one for typical midlatitude atmospheric conditions and one having reduced atmospheric pollutants due to COVID-19 restrictions, both affected by a free tropospheric dust layer), we revealed negligible differences in terms of radiative effect, of the order of +2.6% (SWBOA, cooling behavior) and +1.9% (LWBOA, heating behavior). Moreover, the net heating rate (HR) at the bottom of the atmosphere (BOA) was equal to +0.156 K/d and equal to +2.543 K/d within 1–6 km due to the presence of the dust layer at that height. On the contrary, the reduction in atmospheric pollutants could lead to a negative HR (−0.036 K/d) at the bottom of the atmosphere (BOA) if dust aerosols were absent, while typical atmospheric conditions are estimated to have an almost zero net HR value (+0.006 K/d). The NMMB-BSC forecast model provided the dust mass concentration over Athens, while the air mass advection from the African to the European continent was simulated by the Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 16-year-old girl presented with episodes of nausea, dizziness, and vomiting. Topics discussed include diagnosis of intracranial epidermoid tumors of the fourth ventricle; revealing mass lying within the fourth ventricle in magnetic resonance imaging; and surgical management of posterior fossa epidermoid tumors.

[Display omitted] • 98 L animal fats were converted to 100 L green transportation fuels. • Mild operating hydrogenation conditions have low hydrogen consumption. • Green fuels meet most of the market diesel and HVO standards. • Green fuels can be blended up to 20% v/v with market diesel. • Animal fats storage is feasible up to 4 months prior their conversion. The potential of animal fats hydroconversion is experimentally investigated and validated in industrially relevant scale via the production of 100 L of transportation fuels. The experimental testing has indicated that mild hydrotreatment conditions are associated with low hydrogen consumption without significantly penalties in product quality. The optimal operating conditions (pressure of 6.89 MPa, H 2 /oil ratio of 84.95 Sm3 and LHSV of 1 hr-1) identified were also applied in the industrially relevant scale hydroprocessing pilot to validate the scale-up potential of the technology. The produced fuel is characterized by 5 wppm sulphur, 79.3 cetane index and 44.4 MJ/kg heating value, offering an advantage in compression ignition engines. The produced fuel can be blended up to 20% v/v with fossil diesel rendering a high bio-content diesel abiding by the EN 590 standard. It was found that, up to 20% per volume can be added in diesel without exceeding the requirements for CFPP standards for Greek winter diesel. Towards the commercialization of the technology with respect to the animal fats logistics, a dedicated 6-month storage stability study revealed that animal fats can be stored for up to three to four months at ambient conditions. The findings, indicate that the suggested technology is mature technology as applied successfully in the industrially-relevant-scale providing also the process data. [ABSTRACT FROM AUTHOR]

Objective: Rare disease Background: Pigmented villonodular synovitis is a rare clinical entity, with 2-3% of all PVNS cases affecting the shoulder. Diagnosis is challenging and can elude clinicians for years, with definitive treatment involving arthroscopic or open synovectomy. Case Report: A 50-year-old woman presented with left shoulder pain persisting for 2 years. She was initially conservatively treated by a rheumatologist, with corticosteroid schemes intra-articularly injected and per os, but no improvement of her symptoms was noted. Two years later, she was referred to the Orthopedics Department of our hospital with constant pain in her left shoulder, refractory to the conservative measures. Physical examination revealed tenderness of her shoulder on palpation and limited range of motion. The diagnosis of PVNS was established by preoperative magnetic resonance arthrography (MRA) and confirmed by biopsy from intra-operative tissue sampling. Arthroscopic debridement and synovectomy were performed, yielding good surgical results, and she now reports pain relief, improved function, and no recurrence of symptoms at 1-year follow-up. Conclusions: The diagnosis of PVNS can be elusive for years. MRI and clinical suspicion along with tissue biopsy can set the diagnosis. Shoulder PVNS follows a similar natural history as knee PVNS, with conservative treatment failing and arthroscopic excision providing definite relief. We report a rare case of shoulder PVNS, underscoring the importance of considering PVNS in cases of shoulder pain refractory to conservative treatment. [ABSTRACT FROM AUTHOR]

Background: Hypomagnesaemia is associated with an increased overall mortality in patients with chronic kidney disease on dialysis (CKD-5D). Mediterranean-style diet (MD), having a high magnesium content, can serve as a form of dietary magnesium supplementation. We examined whether there is a potential link between increased Mediterranean Diet score (MDS) and elevated serum magnesium (sMg) to assess its impact on reducing mortality risk in CKD-5D patients. Methods: In this multi-center prospective observational study, 117 CKD-5D patients (66 on hemodialysis and 51 on peritoneal dialysis) with a mean age of 62 ± 15 years were studied for a median follow-up period of 68 months. After baseline assessment, including measurement of sMg and MDS, all patients were followed up for cardiovascular (CV) and all-cause mortality. Results: Forty deaths occurred, 58% of which were cardiovascular. Patients who were above the median value of sMg (2.2 mg/dL) had a 66% reduction in CV (crude HR, 0.34; 95% CI, 0.11–0.70), and 49% reduction in all-cause (crude HR, 0.51; 95% CI, 0.27–0.96) mortality, even after adjustment for age, malnutrition inflammation score, left ventricular mass index, peripheral vascular disease and diabetes. Similar results were obtained when sMg was analyzed as a continuous variable. sMg was associated directly with MDS (r = 0.230; p = 0.012). Conclusions: Higher sMg levels are strongly and independently associated with reduced CV and all-cause mortality in CKD-5D patients. A strong correlation exists between MDS and sMg. Elevated sMg levels, achieved through MD adherence, can significantly reduce CV mortality, implicating MD as a mediator of the association between sMg and CV mortality. [ABSTRACT FROM AUTHOR]

Simple Summary: The content as well as the status of immune cells before immunotherapy administration are indispensable for response. TAA-specific T cells have been associated with poor responses to chemotherapy. However, their role as predictive biomarkers for immunotherapy administration as well as their interplay with other immune system cells is not well understood. Our findings reveal that combined analysis of pre-existing immunity T cells of different immune parameters in treatment-naïve NSCLC patients leads to better prediction tools for immunotherapy response. T-cell-mediated anti-tumoral responses may have significant clinical relevance as a biomarker for response to immunotherapy. The value of peripheral blood pre-existing tumor antigen-specific T cells (PreI+) as a predictive immunotherapy biomarker in NSCLC patients was investigated, along with the frequency of various circulating immune cells. Fifty-two treatment-naïve, stage III/IV NSCLC patients, treated with front-line immune checkpoint inhibitors (ICI)-containing regimens were enrolled. PreI was calculated as the percentages of CD3+IFNγ+ cells after in vitro co-cultures of PBMCs with peptides against four different Tumor-Associated Antigens (TAA). Immunophenotyping of peripheral blood immune cells was performed using multicolor flow cytometry. PreI+ T cells were detected in 44% of patients. Median overall survival (OS) was significantly higher in PreI+ patients compared to PreI– patients (not reached vs. 321 days, respectively; p = 0.014). PreI+ patients had significantly higher numbers of possible exhausted CD3+CD8+PD-1+ cells and lower percentages of immunosuppressive Tregs compared to PreI− patients. Additionally, patients with PreI+ and low numbers of peripheral blood M-MDSCs had a significant survival advantage compared to the rest of the patients. Thus, combining pre-existing tumor antigen-specific immunity before initiation of ICI in NSCLC patients with selected immune-suppressive cells could identify patients who have a favorable clinical outcome when treated with ICI-containing regimens. [ABSTRACT FROM AUTHOR]