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This article summarizes the specific treatment options in the combined mother-child treatment for women with postpartum psychiatric disorders. The incidence of postpartum mental illness is high, especially for postpartum depression that probably occurs in10-15 % of cases. Mental disorders not only have a negative impact on the mental health of the women affected, such as chronification and suicidal tendencies but can also adversely affect the mother-child relationship as well as the emotional and cognitive development of the child. For these reasons it is important, also under the aspects of a primary prevention with respect to the children of mentally ill mothers, to provide a needs-oriented, timely and disorder-specific interactional therapy, which also considers the long-term aspects of treatment. At the Celenus Klinik Carolabad in Chemnitz an integrated treatment model, the 'Carola PLUS', could be established that caters for the particularly high demands of combined care and treatment for both mother and child. [ABSTRACT FROM AUTHOR]

We present a second family with survival to adulthood and dominant transmission of the Torrance-Luton type of platyspondylic chondrodysplasia, and demonstrate the radiographs at different ages together with radiographs and further data of the first family which was published in the Journal of Pediatrics (J Pediatr 136:411-413). Two families are described with survival to adulthood and dominant transmission of the Torrance-Luton type of platyspondylic chondrodysplasia. Although lethality is increased in patients with this disorder, mild expressions of the genetic defect are compatible with survival into adulthood. The heterogeneous group of platyspondylic lethal skeletal dysplasias (PLSD) originally included thanatophoric dysplasias (TD1/2: MIM 187600, 187100) as the most common forms of this condition, as well as TD variants San Diego type (PLSD-SD: MIM 270230) and Torrance-Luton type (PLSD-TL: MIM 151210). Fibroblast growth factor receptor 3 ( FGFR3) gene mutations have been detected in TD1/2 and PLSD-SD. Molecular studies in one of our two families with the Torrance-Luton type did not disclose mutations in the FGFR3 coding region, suggesting that this type of platyspondylic chondrodysplasia is not a thanatophoric dysplasia variant. In contrast to TD1/2 and PLD-SD, the Torrance-Luton type platyspondylic dysplasia is compatible with survival to adulthood. [ABSTRACT FROM AUTHOR]

ABSTRACT We report on three pregnancies complicated by Adams–Oliver syndrome in a consanguineous Turkish couple. Two cases were correctly diagnosed prenatally at 22+3 and 13+0 weeks gestation following the first case of Adams–Oliver syndrome in which severe anomalies of the extremities were observed at 26+5 weeks’ gestation. In this first case, the diagnosis of Adams–Oliver syndrome was made following termination of pregnancy at 27+2 weeks’ gestation. In all three cases, autopsy was performed. All fetuses showed anomalies of the extremities, aplasia cutis and symmetric defects of the skull, with bone being replaced by collagenous tissue. Although there have been numerous cases of the postnatal diagnosis of Adams–Oliver syndrome following termination of pregnancy, this is the first description of the prenatal diagnosis of this disorder. [ABSTRACT FROM AUTHOR]

A single-ended low noise amplifier in 65 nm CMOS for applications at 60 GHz is presented. Its measured gain and noise figure at the centre frequency of 57 GHz are 19.1 dB and 5.5 dB, respectively, and it provides wideband matching. Transistors in the design have an asymmetrically fingered layout which reduces parasitic capacitances while simultaneously allowing for higher channel current densities. [ABSTRACT FROM AUTHOR]

The NA62 experiment at CERN targets the measurement of the ultra-rare K + → π + ν ν ¯ decay, and carries out a broad physics programme that includes probes for symmetry violations and searches for exotic particles. Data were collected in 2016–2018 using a multi-level trigger system, which is described highlighting performance studies based on 2018 data. [ABSTRACT FROM AUTHOR]

The NA62 experiment at CERN targets the measurement of the ultra-rare K + → π + ν ν ¯ decay, and carries out a broad physics programme that includes probes for symmetry violations and searches for exotic particles. Data were collected in 2016–2018 using a multi-level trigger system, which is described highlighting performance studies based on 2018 data. [ABSTRACT FROM AUTHOR]

A sample of 2.8 × 104K+ → π+μ+μ− candidates with negligible background was collected by the NA62 experiment at the CERN SPS in 2017–2018. The model-independent branching fraction is measured to be (9.15 ± 0.08) × 10−8, a factor three more precise than previous measurements. The decay form factor is presented as a function of the squared dimuon mass. A measurement of the form factor parameters and their uncertainties is performed using a description based on Chiral Perturbation Theory at O (p6). [ABSTRACT FROM AUTHOR]

Abstract: The wear of ultra-high molecular weight polyethylene (UHMWPE) components has limited the clinical lifespan of total joint replacements (TJR). Current wear quantification methods through gravimetric measurement only allow estimation of total component loss. Wear originating from different bearing surfaces cannot be distinguished. The ability to determine the volume of loss experienced by specific bearing surfaces would be a leap forward in assessing and evaluating prosthesis designs and aid in the development of wear prevention. The purpose of this study was to assess the tracing ability of europium (Eu)- and gadolinium (Gd)-stearates, and to investigate the wear impact of the tracer additions on the base UHMWPE material. Using a pin-on-disc (POD) apparatus, eighteen pins (9.53mm diameter×19.1mm length) were tested in three separate experiments. Each experiment contained n =2 Eu-stearate doped, n =2 Gd-stearate doped UHMWPE pins and n =2 UHMWPE control pins (CP, without tracers). Lubricant samples for chemical quantification of tracer amount and gravimetric pin measurements were obtained every 0.25 million cycles. The overall wear rates of each pin were then calculated. The wear rates of each material grouping were not significantly different from one another (P >0.5), indicating that tracer addition did not adversely affect the wear performance of the conventional UHMWPE material. Both Eu and Gd yielded highly significant correlations (R 2 ≥0.95) between the concentration of tracer quantified in the lubricant samples and the corresponding gravimetric measurements. However, in both cases, the slope was different from 1 (approximated 2). This systematic offset was most likely related to component manufacturing and will be addressed in future studies. In summary, the presented tracer-determined wear quantification method looks promising to accurately track polyethylene wear in lubricant samples. [Copyright &y& Elsevier]

Abstract: In the present work we report on the electrochemical formation towards layers of multiscale MgO nanowhiskers by a two step approach. First, metallic magnesium was anodized under “high-voltage”-conditions in chloride containing ethanol/water mixtures. This results within seconds in the formation of dense areas of magnesium hydroxide nanowhiskers on the surface. The individual as-grown whiskers have a needle tip shape, and a length depending on the growth time of up to 20μm. The whiskers can be transformed to MgO by a thermal annealing process. To gain more insight into this very rapid growth process, the paper describes the influences of the key parameters of the anodization (pH, ion-concentration, electrolyte composition) and the effect of the thermal treatment on the morphology. All steps were characterized using SEM, EDX, XRD and XPS measurements. [Copyright &y& Elsevier]

Abstract: We investigate the ferromagnetic phase of thin epitaxial films of the CMR manganites and by temperature-dependent spectral generalised magneto-optical ellipsometry (SGME). The phase transitions from a paramagnetic insulator to a ferromagnetic metal take place at and , respectively. The measurements covering a spectral range of 0.5–5eV are performed in the temperature range of 25–425K. SGME allows a complete magneto-optical characterisation consisting of the determination of the diagonal components as well as the off-diagonal components of the dielectric tensor within a single measurement. Upon cooling through the Curie temperature, we observe the development of a Drude-like free-carrier response in , indicating the release of previously bound charges. Meanwhile, exhibits a rising magneto-optical response. This reflects, via the increasing degree of spin polarisation of the bands involved in optical transitions, the emergence of ferromagnetism. We tentatively assign spectral features between 2.5 and 4.5eV to transitions involving the Mn-d shell, especially the and levels. [Copyright &y& Elsevier]

Spectral generalized magneto-optical ellipsometry is presented as an optical tool for the simultaneous measurement of the complex index of refraction ñ=n+ik, the complex magneto-optical coupling parameter Q=Qr+iQi (i.e., the Voigt-parameter), and the orientation of the saturation magnetization Ms of isotropic ferromagnetic bulk materials. For wavelengths between 220 nm and 790 nm and at temperatures between 4.2 K and 800 K measurements on iron and permalloy demonstrate the comfortable application of this technique in order to resolve the spectral response of spin-polarized carriers and bands, which can provide valuable insight about the formation of the ferromagnetic state. [ABSTRACT FROM AUTHOR]

We present spectral generalized magneto-optical ellipsometry as an optical tool to investigate magnetic and electronic properties of ferromagnetic materials. The advantage of the simultaneous observation of the dielectric and the magnetic responses within one measurement procedure is crucial for materials with coupled degrees of freedom near a phase transition or during annealing procedures to improve the film quality by removing grain boundaries. Moreover, we show the implementation of this technique within an UHV-cryostat for a temperature range between 4.2 and 800 K and fields up to 40 mT. Examplary measurements on iron and Permalloy demonstrate the comfortable application of this technique. [Copyright &y& Elsevier]

The NA62 experiment reports the branching ratio measurement BR K + → π + ν ν ¯ = 10.6 − 3.4 + 4.0 stat ± 0.9 syst × 10 − 11 at 68% CL, based on the observation of 20 signal candidates with an expected background of 7.0 events from the total data sample collected at the CERN SPS during 2016–2018. This provides evidence for the very rare K+→ π + ν ν ¯ decay, observed with a significance of 3.4σ. The experiment achieves a single event sensitivity of (0.839 ± 0.054) × 10−11, corresponding to 10.0 events assuming the Standard Model branching ratio of (8.4 ± 1.0) × 10−11. This measurement is also used to set limits on BR(K+→ π+X), where X is a scalar or pseudo-scalar particle. Details are given of the analysis of the 2018 data sample, which corresponds to about 80% of the total data sample. [ABSTRACT FROM AUTHOR]

We present a setup for temperature-dependent spectral generalized magneto-optical ellipsometry (SGME). This technique gives access to the electronic as well as the magnetic properties of ferromagnetic materials within one single magneto-optical measurement. It also allows the determination of the orientation of the magnetization. We show spectra of the real and the imaginary part of the refractive index N as well as the magneto-optical coupling parameter Q of permalloy and iron films for in-plane magnetization. Our findings demonstrate the relevance of SGME for the understanding of the interplay between electronic and magnetic properties of ferromagnetics. © 2003 American Institute of Physics. [ABSTRACT FROM AUTHOR]

A search for the K+ → π+X decay, where X is a long-lived feebly interacting particle, is performed through an interpretation of the K+ → π + ν ν ¯ analysis of data collected in 2017 by the NA62 experiment at CERN. Two ranges of X masses, 0–110 MeV/c2 and 154–260 MeV/c2, and lifetimes above 100 ps are considered. The limits set on the branching ratio, BR(K+ → π+X), are competitive with previously reported searches in the first mass range, and improve on current limits in the second mass range by more than an order of magnitude. [ABSTRACT FROM AUTHOR]

The NA62 experiment at the CERN SPS reports a study of a sample of 4 × 109 tagged π0 mesons from K+ → π+π0(γ), searching for the decay of the π0 to invisible particles. No signal is observed in excess of the expected background fluctuations. An upper limit of 4.4 × 10−9 is set on the branching ratio at 90% confidence level, improving on previous results by a factor of 60. This result can also be interpreted as a model- independent upper limit on the branching ratio for the decay K+ → π+X, where X is a particle escaping detection with mass in the range 0.110–0.155 GeV/c2 and rest lifetime greater than 100 ps. Model-dependent upper limits are obtained assuming X to be an axion-like particle with dominant fermion couplings or a dark scalar mixing with the Standard Model Higgs boson. [ABSTRACT FROM AUTHOR]

The NA62 experiment reports an investigation of the K + → π + ν ν ¯ mode from a sample of K+ decays collected in 2017 at the CERN SPS. The experiment has achieved a single event sensitivity of (0.389 ± 0.024) × 10−10, corresponding to 2.2 events assuming the Standard Model branching ratio of (8.4 ± 1.0) × 10−11. Two signal candidates are observed with an expected background of 1.5 events. Combined with the result of a similar analysis conducted by NA62 on a smaller data set recorded in 2016, the collaboration now reports an upper limit of 1.78 × 10−10 for the K + → π + ν ν ¯ branching ratio at 90% CL. This, together with the corresponding 68% CL measurement of ( 0.48 − 0.48 + 0.72 ) × 10−10, are currently the most precise results worldwide, and are able to constrain some New Physics models that predict large enhancements still allowed by previous measurements. [ABSTRACT FROM AUTHOR]

Larsen syndrome shows a broad spectrum of clinical manifestation ranging from a lethal form of the disorder to a mild clinical expression with absence of major diagnostic features. Here we show that even intrafamilial manifestation may vary extremely to the point that Larsen syndrome in a father has been diagnosed only by typical sonographic features in an affected fetus. [ABSTRACT FROM AUTHOR]

A case of diffuse mesangial sclerosis (DMS) associated with a number of undescribed congenital anomalies is reported. The occurrence of additional anomalies, especially ocular anomalies, is a common finding in DMS. However, neither megalocornea, Dandy-Walker malformation, postaxial hexadactyly, rocker-bottom feet, nor atrial septal defect, as observed in our patient, has been reported previously in association with DMS. This case might be considered an atypical manifestation of the Galloway-Mowat syndrome. In contrast to most cases of DMS, the patient revealed intrauterine proteinuria as the placenta was enlarged to 31% of birth weight. This case demonstrates that the large placenta, >25% of birth weight, is not only pathognomonic of the congenital nephrotic syndrome of the Finnish type but can also occur in DMS. [ABSTRACT FROM AUTHOR]

The article presents case reports related to allergic contact dermatitis from idoxuridine (IDU). The efficacy of locally applied idoxuridine depends on its concentration and contact dermatitis due to this is rare. The sensitization potential of IDU is low. In the first case a 66 year old non atopic man was treated for herpes zoster of dermatomes with a IDU solution, the treatment was discontinued after some time but later he observed swelling and pain in the lumbar region, finally he was cured with corticosteroid therapy.

Abstract: Self-assembled titanium oxide nanotubular (NTs) arrays with vertical arrangement, tailored morphological properties and variable thickness were prepared by electrochemical anodization in ethylene glycol containing electrolytes. The NTs present significant UV photocatalysis against toluene and benzene at ppb concentrations, under normal conditions of temperature and pressure. The photocatalytic activity depends on the length of the NT arrays, showing a tendency of saturation for thickness above 2.5μm and maximum efficiency for samples with thickness of 12μm. The optimum NT structures outperform over standard Degussa P25 films rendering them very promising for outdoor photocatalytic applications. [Copyright &y& Elsevier]

Abstract: A study has been carried out of nanotubular anodic films formed on titanium at 20V in fluoride/glycerol electrolyte, containing up to 50vol.% water. Anodizing was terminated at a charge of 1Ccm−2. Addition of water resulted in an increased current and significantly reduced tube length associated with increased oxygen gas evolution. Films formed in the absence of added water were amorphous by electron diffraction, whereas water addition also led to the formation of anatase and rutile. The barrier layer was relatively thin for electrolyte of low water content, due to either a voltage drop in the electrolyte close to the anode or to a change in the film composition affecting the electric field across the layer. Ribbing of the external walls of the nanotubes was more evident in the presence of water. It is suggested that dissolution of a fluoride-rich layer, which separates the nanotubes, accompanies the nanotube growth, with the dissolution allowing transient film formation at the external walls of the nanotubes when the residual layer is sufficiently thin. [Copyright &y& Elsevier]

Zerres K, Senderek J, Rudnik-Schöneborn S, Eggermann T, Kunze J, Mononen T, Kääriäinen H, Kirfel J, Moser M, Buettner R, Bergmann C. New options for prenatal diagnosis in autosomal recessive polycystic kidney disease by mutation analysis of the PKHD1 gene. Due to the poor prognosis of severe autosomal recessive polycystic kidney disease (ARPKD), there is a strong demand for prenatal diagnosis (PD). Reliable PD testing is possible by molecular genetic analysis only. Although haplotype-based analysis is feasible in most cases, it is associated with a risk of misdiagnosis in families without pathoanatomically proven diagnosis. Linkage analysis is impossible in families where DNA of the index patient is not available. Direct mutation analysis of the recently identified polycystic kidney and hepatic disease 1 gene opens new options in families to whom a reliable PD cannot be offered on the basis of linkage analysis. We for the first time report two cases with PD based on mutation detection, illustrating the new options for PD in ARPKD. [ABSTRACT FROM AUTHOR]