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Abstract. Involvement of the dopaminergic system has been suggested in patients suffering from attention deficit hyperactivity disorder (ADHD) since the symptoms can be successfully treated with methylphenidate, a potent blocker of the dopamine transporter (DAT). This study reports the findings on the status of the DAT in adults with ADHD before and after commencement of treatment with methylphenidate, as measured using [[sup 99m]Tc]TRODAT-1. Seventeen patients (seven males, ten females, aged 21-64 years, mean 38 years) were examined before and after the initiation of methylphenidate treatment (3 x 5 mg/day). All subjects were injected with 800 MBq [[sup 99m]Tc]TRODAT-1 and imaged 3 h p.i. Singlephoton emission tomography (SPET) scans were acquired using a triple-headed gamma camera. For semiquantitative evaluation of the DAT, transverse slices corrected for attenuation were used to calculate specific binding in the striatum, with the cerebellum used as background [(STR-BKG)/BKG]. Data were compared with an age-matched control group. It was found that untreated patients presented with a significantly increased specific binding of [[sup 99m]Tc]TRODAT-1 to the DAT as compared with normal controls [(STR-BKG)/BKG: 1.43 +/- 0.18 vs 1.22 +/- 0.06, P<0.001]. Under treatment with methylphenidate, specific binding decreased significantly in all patients [(STR-BKG)/BKG: 1.00 +/- 0.14, P<0.001].... [ABSTRACT FROM AUTHOR]

Poster: Clinical track: Prostate PO-1169: Influence of localisation of PSMA-positive oligo-metastases on efficacy of metastasis-directed EBRT N. Schmidt-Hegemann, S. Kroeze, C. Henkenberens, M. Vogel, S. Kirste, J. Becker, I. Burger, T. Derlin, P. Bartenstein, M. Eiber, M. Mix, C. Lafougere, A. Müller, A. Grosu, S. Combs, H. Christiansen, M. Guckenberger, C. Belka. [Extracted from the article]