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This paper follows the traces of Tajik and Judeo-Tajik literature in the early Soviet period and compares some prominent works and biographies of Tajik and Bukharan Jewish writers. In the 1920s and 1930s, national literatures were heavily supported by the Party and the state and used as vehicles for propagating the new ideology, creating Soviet nationalities (the Tajiks) and national minorities (the Bukharan Jews). For a period that lasted about ten years, parallels and mutual influences within an emerging scene of Tajik and Bukharan Jewish literature are well documented. While this laboratory of Soviet nation-building continued with the Tajiks, the Judeo-Tajik project was stopped in the late 1930s. From then until the end of the Soviet period, Bukharan Jewish writers, artists, and intellectuals contributed to mainstream Tajik culture. [ABSTRACT FROM AUTHOR]

Scholarly and popular literature dealing with the Persian-speaking Jews of Central Asia tends to divide the history and historiography of these Jewish communities along political boundaries that came into being only in the late nineteenth and early twentieth centuries. The "Bukharan" Jews are commonly portrayed as an ancient, secluded, and isolated "ethnic" Jewish group, disconnected from neighbouring Jewish communities and the wider Jewish world. Looking into a set of Bukharan Jewish family stories, this article is meant to complicate the narrative, offering "mobility" and the metaphor of "border crossing" as a different paradigm to understand Jewish history and geography in Central Asia, Afghanistan, and Iran. [ABSTRACT FROM AUTHOR]

This paper presents the development and transformations of Bukharan Jewish newspapers and periodicals (1910–38) and situates them in the broader Central Asian mediascape. Over a period of 30 years, the Bukharan Jewish press was transformed from a pioneering privately owned enterprise that served the needs of the Jewish communities throughout Central Asia to one owned and regulated by the Soviet state, serving as a tool to transmit propaganda and to shape and educate a predefined 'national minority group'. The paper argues that the introduction of a Bukharan Jewish press in 1910 was intended to create a modernized language and ethnic awareness among the Jews of Central Asia. In the 1930s, Bukharan Jewish newspapers and journals were radically Sovietized and finally shut down by the state. From then until the collapse of the Soviet Union, no Bukharan Jewish publications appeared in the bloc and the existence of a distinct Central Asian Jewish identity was largely ignored. This case study sheds light on Tsarist and Soviet minorities' policies and helps us to better understand the various changes experienced and the cultural adaptations made by many 'minorities' of Central Asia in the Age of Colonialism. [ABSTRACT FROM AUTHOR]

Dengue non-structural protein (NS1) is an important diagnostic marker during the acute phase of infection. Because NS1 is partially conserved across the flaviviruses, a highly specific DENV NS-1 diagnostic test is needed to differentiate dengue infection from Zika virus (ZIKV) infection. In this study, we characterized three newly isolated antibodies against NS1 (A2, D6 and D8) from a dengue-infected patient and a previously published human anti-NS1 antibody (Den3). All four antibodies recognized multimeric forms of NS1 from different serotypes. A2 bound to NS1 from DENV-1, -2, and -3, D6 bound to NS1 from DENV-1, -2, and -4, and D8 and Den3 interacted with NS1 from all four dengue serotypes. Using a competition ELISA, we found that A2 and D6 bound to overlapping epitopes on NS1 whereas D8 recognized an epitope distinct from A2 and D6. In addition, we developed a capture ELISA that specifically detected NS1 from dengue viruses, but not ZIKV, using Den3 as the capture antibody and D8 as the detecting antibody. This assay detected NS1 from all the tested dengue virus strains and dengue-infected patients. In conclusion, we established a dengue-specific capture ELISA using human antibodies against NS1. This assay has the potential to be developed as a point-of-care diagnostic tool. [ABSTRACT FROM AUTHOR]

Dengue is a mosquito-borne infection caused by dengue virus (DENV) of the Flaviviridae family. In another paediatric cohort, high anti-DENV antibody levels, >1:320 titres, protected against symptomatic dengue, whereas individuals with anti-DENV antibody titres between 1:21 and 1:80 were more susceptible to severe dengue [[2]]. Furthermore, in early disease phase, higher afucosylated IgG1 abundance was observed in secondary DENV infection compared to primary infection, and these antibodies were predictive of severe dengue [[21]]. [Extracted from the article]

Focuses on analyses conducted to determine the possible sources of contamination in polymerase chain reaction (PCR) experiments, which indicated that water quality was one of the problems. Reference to some of the other factors which may have limited the results of the experiment; Measures which can be taken to avoid cross contamination.

A program of blood residue analysis at Çayönü Tepesi in SE Turkey was undertaken from 1984 to 1987. The research began as an investigation of the feasibility of detecting and identifying blood residues in a field setting with subsequent additional analyses and verification in the home laboratory. In-field and laboratory techniques included Labstix detection of hemoglobin, and the identification of species was done using hemoglobin crystallization. Immunological techniques were used in the laboratory to verify the identification of blood. The results are significant. Research centered on residue from the ‘skull building’ where the blood of Bos primigenius (the extinct progenitor of modern cattle), sheep, and goat were found in addition to human blood. The conjunction of animal and human blood in a structure where more than 90 human skulls as well as complete and partial skeletons were interred suggests some yet-unknown ritual/mortuary function. [ABSTRACT FROM AUTHOR]

Examines the relationship between human hunters who used fluted points and their prey as evidenced by preserved organic, blood residues, with focus on archaeology. Reference made to human occupation of North America; What are fluted points; Methodology used in the examination process.

Bone substitute materials loaded with mediators that stimulate fracture healing are demanded in the clinical treatment in trauma surgery and orthopedics. Brain-derived neurotrophic factor (BDNF) enhances the proliferation and differentiation of mesenchymal stem cells into osteoblast. To load the implants with BDNF, a drug delivery system that allows the release of BDNF under spatiotemporal control would improve functionality. Polyelectrolyte complex nanoparticles (PECNP) have been reported as a suitable drug delivery system. The suitability of PECNP in contact with osteocytes as the main cell type of bone is not known so far. Thus, we aimed to verify that BDNF and PECNP loaded with BDNF (PECNP+BDNF) as well as pure PECNP have no negative effects on osteocytes in vitro. Therefore, the murine osteocyte cell line MLO-Y4 was treated with BDNF and PECNP+BDNF. The effects on proliferation were analyzed by the BrdU test (n = 5). The results demonstrated a significant increase in proliferation 24 h after BDNF application, whereas PECNP+BDNF did not lead to significant changes. Thus, we conclude that BDNF is an appropriate mediator to stimulate osteocytes. Since the addition of PECNP did not affect the viability of osteocytes, we conclude that PECNP are a suitable drug delivery system for bone implants. [ABSTRACT FROM AUTHOR]

Background: Germany's high density of under-equipped hospitals and anticipated surge in orthopedic and trauma surgery-related diseases by 2030, combined with personnel shortages, are expected to increase patient transfers between hospitals, an issue that urgently needs standardized protocols. Despite some existing cooperative agreements, such as between joint-replacement centers or within the Trauma Network DGU®, these measures do not adequately address the full range of patient-transfer cases, including those due to a lack of specialization or staff shortages, resulting in delayed treatment and potential health risks. This study aims to dissect the intricacies of interhospital transfers in orthopedics and trauma surgery across Germany, focusing on understanding the underlying reasons for transfers, comparing the operational structures of small and large hospitals, and laying the groundwork for future standardized protocols to enhance patient care. Material and Methods: A cross-sectional study was conducted in the form of an online survey via SoSci Survey, which was directed at orthopedic surgeons and trauma surgeons working in hospitals in Germany. The 22-question survey gathered information on participants' clinic roles, departmental details, transfer processes, frequent diagnoses, perceptions of transfer quality, and improvement areas. The survey was sent to orthopedic and trauma surgeons in Germany by the specialist society. The data were analyzed using descriptive and inferential statistics to ensure a comprehensive insight into interhospital transfer practices. Results: The study involved 152 participants from various hospital ranks and located in different hospital sizes and types across rural and urban areas. A significant difference was observed between the care structures of basic/regular care and central/maximum care hospitals, especially regarding the available facilities and specialties. These findings suggest improvements such as better patient documentation, increased digital communication, optimized patient distribution, and standardization of transfer requests, among others. Conclusions: This study highlights the urgent need for improved protocols and resource allocation to eliminate inequalities in transfers between hospitals in orthopedics and trauma surgery in Germany. [ABSTRACT FROM AUTHOR]

The correct statement is: CLLC receives support from Ministry of Higher Education (MOHE) Malaysia, under Fundamental Research Grant Scheme: ID FRGS/1/2020/SKK0/TAYLOR/02/1. In the Funding statement, one of the funders is listed incorrectly as Ministry of Education (MOE). [Extracted from the article]

We compare the performance of the linear regression model, which is the current standard in science and practice for cross-sectional stock return forecasting, with that of machine learning methods, i.e., penalized linear models, support vector regression, random forests, gradient boosted trees and neural networks. Our analysis is based on monthly data on nearly 12,000 individual stocks from 16 European economies over almost 30 years from 1990 to 2019. We find that the prediction of stock returns can be decisively improved through machine learning methods. The outperformance of individual (combined) machine learning models over the benchmark model is approximately 0.6% (0.7%) per month for the full cross-section of stocks. Furthermore, we find no model breakdowns, which suggests that investors do not incur additional risk from using machine learning methods compared to the traditional benchmark approach. Additionally, the superior performance of machine learning models is not due to substantially higher portfolio turnover. Further analyses suggest that machine learning models generate their added value particularly in bear markets when the average investor tends to lose money. Our results indicate that future research and practice should make more intensive use of machine learning techniques with respect to stock return prediction. [ABSTRACT FROM AUTHOR]