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1. Fluorous Tagged N-Hydroxy Phthalimide for the Parallel Synthesis of O-Aryloxyamines.

Author

Florence S. Gaucher-Wieczorek, Ludovic T. Maillard, Bernard Badet, and Philippe Durand

Subjects
*IMIDES, *CARBONYL compounds, *AMMONIA, *BORIC acid, *AMINES, *TAGUCHI methods, *COMBINATORIAL chemistry
Abstract

The parallel synthesis of O-aryloxyamines remains an unfulfilled need in the field of medicinal chemistry and fragment-based approaches. To fill this gap a solution-phase two-step process based on (1) a copper-catalyzed cross-coupling of aryl boronic acids with a fluorous tagged N-hydroxyphthalimide, and (2) a supported aminolysis was designed and optimized using Taguchi’s method. A library of O-aryloxyamines was synthesized in high yields with high purity and diversity. [ABSTRACT FROM AUTHOR]

Published
2010
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