1. Clinical, Endoscopic, and Histopathology Features of Esophageal Graft-vs-Host Disease.
- Author
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Kamboj, Amrit K., Agarwal, Siddharth, Yarlagadda, Manoj K., Archila, Luisa Ricaurte, Hagen, Catherine E., and Katzka, David A.
- Subjects
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ESOPHAGUS diseases , *HISTOPATHOLOGY , *DIGESTIVE system endoscopic surgery , *DEGLUTITION disorders , *HEARTBURN , *EOSINOPHILIC esophagitis - Abstract
INTRODUCTION: To describe the clinical, endoscopic, and histopathology features of esophageal graft-vs-host disease (GVHD). Methods: Patients with biopsy-proven esophageal GVHD diagnosed at Mayo Clinic between 2000 and 2021 were included. Results: In 43 esophageal patients, other organ GVHD was present in 58% before and 86% at esophageal GVHD diagnosis. Esophageal specific symptoms were uncommon (dysphagia 26% and odynophagia/heartburn 5%). Esophagogastroduodenoscopy was abnormal in 72% patients demonstrating erosive esophagitis, ulceration, desquamation, or rings/furrows in a diffuse or focal pattern. DISCUSSION: There should be a low threshold for esophageal biopsies for GVHD because esophageal symptoms and endoscopic findings may be nonspecific or absent. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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