9 results on '"Mannino, Elizabeth"'
Search Results
2. Impact of Non-Automobile Rollover Accidents on Patient Outcomes at an Appalachian Level I Trauma Center.
- Author
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Mannino, Elizabeth A., Leonard, Matthew, and Burns, Bracken J.
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TRAUMA centers , *ROLLOVER vehicle accidents , *SPINAL injuries - Abstract
The objective of this study was to evaluate outcomes of patients involved in rollover accidents in non-automobile vehicles in a rural level I trauma center. This was a retrospective study including a total of 127 patients over 5 years who were admitted to our level I trauma center following rollover accidents in either of the following: ATV, lawnmower, or tractor. Patients were significantly older in the tractor and lawnmower rollover groups, and patients less than 65 years old were significantly more likely to sustain an injury in a rollover accident when compared to those greater than 65. Patients with extremity fractures secondary to tractor rollovers were more likely to be older, and patients who sustained spinal injuries secondary to tractor rollovers were more likely to be younger. Non-automobile rollovers have the potential to cause traumatic injuries; however, there does not appear to be 1 vehicle type that is more prone to injury. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Surgical Repair of Idiopathic Mid-Forearm Radial Artery Aneurysm Using a Reversed Greater Saphenous Vein Interposition Graft.
- Author
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Mannino, Elizabeth A., Byrnes, Kari Anna, Smith, Lou M., and Hopkins, Steven P.
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RADIAL artery , *SAPHENOUS vein , *ANEURYSMS , *MEDICAL literature , *VASCULAR surgery , *BLOOD vessel prosthesis , *TRANSPOSITION of great vessels - Abstract
Idiopathic, non-traumatic, radial artery aneurysms are rare in medical literature. This report presents the case of a 56-year-old man who was incidentally found to have a 1.01 cm × 1.31 cm left radial artery aneurysm during a carpal tunnel workup. The patient had no other aneurysms, nor any known predisposing diseases that could explain his condition. We proceeded with surgical intervention to prevent future complications. We describe the use of a greater saphenous vein interposition graft for the repair of an idiopathic mid-forearm radial artery aneurysm. The patient had an uncomplicated recovery course following repair. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. Congenital methemoglobinemia type II in a 5‐year‐old boy.
- Author
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Mannino, Elizabeth A., Pluim, Thomas, Wessler, Jacob, Cho, Megan T., Juusola, Jane, and Schrier Vergano, Samantha A.
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LEUKODYSTROPHY , *NEUROLOGICAL errors , *EPILEPSY , *RARE diseases - Abstract
Key Clinical Message: Congenital Methemoglobinemia is a rare neurologic condition which can mimic other diseases such as epilepsy syndromes and leukodystrophies. The responsible gene,
CYB5R3 , is not typically included on commonly order neurologic and epilepsy panels. We recommend that laboratories include this gene on these tests which often precede larger‐scale genetic studies. [ABSTRACT FROM AUTHOR]- Published
- 2018
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5. A National Survey Assessing the Variability in the Management of Traumatic Cardiac Arrest.
- Author
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Roche, Keelin F., Quinn, Megan, Mannino, Elizabeth A., Ventura, Liane, Brown, Cecelia, Lawson, Christy M., and Burns, Bracken J.
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CARDIAC arrest , *ADVANCED cardiac life support , *INTERPERSONAL conflict , *STATISTICAL hypothesis testing , *CARDIAC resuscitation - Abstract
Background: Resuscitation of traumatic cardiac arrest (TCA) is variable, with approaches that overlap Advanced Trauma Life Support (ATLS) and Advanced Cardiac Life Support (ACLS) algorithms. There is no standard algorithm for TCA, with some withholding ACLS protocols given abysmal outcomes. This study aims to assess surgeon practices and attitudes toward resuscitation practices in TCA. Materials and Methods: A 16-question web-based survey was distributed to the membership of a national trauma association. Respondent demographics and management of TCA were analyzed. Chi-squared tests determined statistical significance. Open-ended responses were coded and analyzed inductively. Results: Two hundred and three surveys were completed. 73.4% of respondents reported utilizing ACLS, while 26.6% reported they never utilized ACLS. A statistically significant difference in the performance of ACLS was found based on number of years in practice (P =.025) and the state of practice (P =.006). There was no significant difference in self-reported survival rates or legal, ethical, or interpersonal conflicts. Qualitative data highlighted themes of interpersonal conflict and futility. Discussion: This study shows that one-quarter of respondents never utilize ACLS in TCA. Of those that utilize ACLS, there was variability in the technique, indication, and duration of resuscitation. Despite significant variability in technique, there appears to be similar survival rates and incidence of conflict. The association between years in practice and ACLS use suggests this may represent an emerging change in practice. The low response rate limits generalizability; however, there is significant variability in practice, highlighting a need for evidence-based guidelines. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. Application of the Geriatric Trauma Outcome Score in a Rural Setting.
- Author
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Archer, Allen D., Hahamyan, Henrik A., White-Archer, Melissa L., Mannino, Elizabeth A., Roche, Keelin F., and Burns, J. Bracken
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ERYTHROCYTES , *TRAUMA registries , *RURAL population , *TRAUMA surgery , *TRAUMA centers - Abstract
Objective: To retrospectively apply the Geriatric Trauma Outcome (GTO) score to the patient population of a rural South Central Appalachian level 1 trauma center and identify the potential utility of the GTO score in guiding goals of care discussions. Methods: Trauma registry data was extracted for 5,627 patients aged 65+ from 2017 to 2021. GTO score was calculated for each patient. Descriptive statistics were calculated for age, Injury Severity Score (ISS), GTO score, receipt of red blood cells, discharge status, and code status. A simple logistic regression model was used to determine the relationship between GTO score and discharge status. The probability of mortality was then calculated using GTO score, and the distribution of code status among patients with ≤50, 51-75%, and >75% probability of mortality was examined. Results: For every 10-point increase in GTO score, odds of mortality increased by 79% (OR = 1.79; P <.001). Patients had an estimated 50% probability of mortality with a GTO score of 156, 75% with 174, and 99% with a score of 234, respectively. Seventeen patients had a GTO score associated with >75% probability of mortality. Of those 17 patients, four retained a full code status. Conclusions: Our analysis demonstrates that the GTO score is a validated measure in a rural setting and can be an easily calculated metric to help determine a geriatric patient's probability of mortality following a trauma. The results of our study also found that GTO score can be used to inform goals of care discussions with patients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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7. Coronary Artery Calcification and Risk of Cardiac Complication in Geriatric Trauma Population.
- Author
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King, Sarah A., Jenkins, Jacob D., Livesay, James, Ji-Ming Yune, Mannino, Elizabeth, Webb, Jason M., Hill, Haddon C., Baljepally, Raj, Daley, Brian J., and Smith, Lou M.
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HEART disease risk factors , *WOUNDS & injuries , *RISK assessment , *CONTINUING education units , *T-test (Statistics) , *SCIENTIFIC observation , *DESCRIPTIVE statistics , *CHI-squared test , *MANN Whitney U Test , *LONGITUDINAL method , *ODDS ratio , *STATISTICS , *ANALYSIS of variance , *CORONARY artery calcification , *DATA analysis software , *CONFIDENCE intervals , *DISEASE complications , *OLD age - Abstract
BACKGROUND: Better means of identifying patients with increased cardiac complication (CC) risk is needed. Coronary artery calcification (CAC) is reported on routine chest CT scans. We assessed the correlation of CAC and CCs in the geriatric trauma population. STUDY DESIGN: A prospective, observational study of patients 55 years and older who had chest CT scan from May to September 2022 at a level 1 trauma center. Radiologists scored CAC as none, mild, moderate, or severe. None-to-mild CAC (NM-CAC) and moderate-to-severe CAC (MS-CAC) were grouped and in-hospital CCs assessed (arrhythmia, ST elevation myocardial infarction [STEMI], non-STEMI, congestive heart failure, pulmonary edema, cardiac arrest, cardiogenic shock, and cardiac mortality). Univariate and bivariate analyses were performed. RESULTS: Five hundred sixty-nine patients had a chest CT, of them 12 were excluded due to missing CAC severity. Of 557 patients, 442 (79.3%) had none-to-mild CAC and 115 (20.7%) has MS-CAC; the MS-CAC group was older (73.3 vs 67.4 years) with fewer male patients (48.7% vs 54.5%), had higher cardiac-related comorbidities, and had higher abbreviated injury scale chest injury scores. The MS-CAC group had an increased rate of CC (odds ratio [OR] 1.81, p = 0.016). Cardiac complications statistically more common in MS-CAC were congestive heart failure (OR 3.41, p = 0.003); cardiogenic shock (OR 3.3, p = 0.006); non-STEMI I or II (OR 2.8, p = 0.017); STEMI (OR 5.9, p = 0.029); and cardiac-caused mortality (OR 5.27, p = 0.036). No statistical significance between pulmonary edema (p = 0.6), new-onset arrhythmia (p = 0.74), or cardiac arrest (p = 0.193). CONCLUSIONS: CAC as reported on chest CT scans demonstrates a significant correlation with CC and should warrant additional cardiac monitoring. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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8. F.14. Coronary Artery Abnormalities in Hyperimmunoglobulin E Syndrome
- Author
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Mannino, Elizabeth, Gharib, Ahmed, Hsu, Amy, Heimall, Jennifer, Holland, Steven, and Freeman, Alexandra
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- 2009
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9. Drosophila Nipped-B Mutants Model Cornelia de Lange Syndrome in Growth and Behavior.
- Author
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Wu, Yaning, Gause, Maria, Xu, Dongbin, Misulovin, Ziva, Schaaf, Cheri A., Mosarla, Ramya C., Mannino, Elizabeth, Shannon, Megan, Jones, Emily, Shi, Mi, Chen, Wen-Feng, Katz, Olivia L., Sehgal, Amita, Jongens, Thomas A., Krantz, Ian D., and Dorsett, Dale
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DROSOPHILA genetics , *GENETIC mutation , *INSECT growth , *INSECT memory , *LEARNING , *CIRCADIAN rhythms , *INSECTS - Abstract
Individuals with Cornelia de Lange Syndrome (CdLS) display diverse developmental deficits, including slow growth, multiple limb and organ abnormalities, and intellectual disabilities. Severely-affected individuals most often have dominant loss-of-function mutations in the Nipped-B-Like (NIPBL) gene, and milder cases often have missense or in-frame deletion mutations in genes encoding subunits of the cohesin complex. Cohesin mediates sister chromatid cohesion to facilitate accurate chromosome segregation, and NIPBL is required for cohesin to bind to chromosomes. Individuals with CdLS, however, do not display overt cohesion or segregation defects. Rather, studies in human cells and model organisms indicate that modest decreases in NIPBL and cohesin activity alter the transcription of many genes that regulate growth and development. Sister chromatid cohesion factors, including the Nipped-B ortholog of NIPBL, are also critical for gene expression and development in Drosophila melanogaster. Here we describe how a modest reduction in Nipped-B activity alters growth and neurological function in Drosophila. These studies reveal that Nipped-B heterozygous mutant Drosophila show reduced growth, learning, and memory, and altered circadian rhythms. Importantly, the growth deficits are not caused by changes in systemic growth controls, but reductions in cell number and size attributable in part to reduced expression of myc (diminutive) and other growth control genes. The learning, memory and circadian deficits are accompanied by morphological abnormalities in brain structure. These studies confirm that Drosophila Nipped-B mutants provide a useful model for understanding CdLS, and provide new insights into the origins of birth defects. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
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