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Viscosupplementation is a new therapy for the treatment of OA and refers to the i.a injection of hyaluronic acid (HA), a high molecular weight polysaccharide which is a major component of synovial fluid and cartilage, in order to relieve pain and improve function, In OA, the molecular weight and concentration of HA are diminished. The concept of viscosupplementation is based on the hypothesis that IA injections of HA could help restore the vis-coelasticity of the synovial fluid and promote the endogenous synthesis of a higer molecular weight and possibly more functional hyaluronan, thereby improving mobility and articular function, and reducing pain. Hyaluronan and its derivatives to have a structure modifying action by retarding structural progression in OA of the knee is considered. [ABSTRACT FROM AUTHOR]

Objectives. Study the articular involvement present in inflammatory bowel disease, mainly in Crohn disease (CD) and ulcerohaemorrhagic rectocolitis (UHRC), the genetic and immune mechanism underlying the occurrence of these disorders and their complications, response to therapy, as well as the value of the immunoserology tests. Material and methods. The group of 204 patients that were monitored, consisted of two subgroups: 50 patients with CD, and 154 patients with UHRC and have been enrolled in a prospective longitudinal study. The patients were included in the study group according to strictly established criteria, taking into account the underlying inflammatory bowel disease that triggered the respective articular disorders, have been assessed according to a protocol including both individual parameters (clinical, biological), endoscopic, histopathologic, radiographs, RMN, CT evaluation. Results. 93 patients had joint manifestations. 65 of them had developed due articular lesions in ulcerative colitis and 28 Crohn's disease. In ulcerative colitis Joint damage occurred as follows: 58.5% sacroiliitis (38 cases), ankylosing spondylitis 7.7% (5) 10.7% acute arthritis (7). In Crohn's disease were detected: sacroiliac 35.8% (10 patients), 42.9% peripheral arthritis (12), acute arthritis 7.1% (2 cases), reactive arthritis 14.2% (4) with germs Salmonella (3) and Shigella (1). In 71 patients from those with articular manifestations of detecting the presence of HLAB27. Conclusions. Joint damage was correlated with the severity, type of inflammatory bowel disease (IBD) reflecting the state of activity. Joint manifestations were detected mainly in ulcerative colitis increased, unlike the literature. [ABSTRACT FROM AUTHOR]