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Background. Literature comparing different alternatives for pain control in the immediate postoperative period of pediatric acute appendicitis (PAA) is scarce. Materials and methods. We prospectively compared the analgesic and emetogenic profile of intravenous ibuprofen and metamizole in the immediate postoperative period of PAA. For this purpose, we used a sample of patients operated on in 2021 in our center. Participants were recruited on arrival at the Emergency Department and histopathological confirmation of the diagnosis was obtained in all of them. Pain was evaluated every 8 hours after the surgery with validated visual analog scales ranging from 0 to 10 points. Repeated measures ANOVA was used to compare the evolution of pain in the 48 hours after surgery between the two groups. Results. The sample included 95 patients (65% males) with a mean age of 9.7 years (sd: 3.14). 41 patients were treated with Ibuprofen (group 1) and 54 with metamizole (group 2). No significant differences were found in the level of pain either in the comparisons of point measurements or in its evolution in the 48 hours after surgery (p= 0.58). After adjusting for the received fluid therapy, children in the metamizole group had significantly more emetic episodes and needed significantly more doses of ondansetron. Conclusions. In our cohort, ibuprofen had a similar analgesic efficacy and a better emetogenic profile than metamizole in the immediate postoperative period of PAA. Future prospective, adequately controlled studies with larger sample sizes are needed to validate these findings. [ABSTRACT FROM AUTHOR]

Background: Inflammation related molecules such as tumor necrosis factor‐α (TNF‐α), interleukin 6 (IL‐6), and cardiotrophin‐1 (CT‐1) are highly expressed in obese individuals and could partly explain some comorbidities associated to obesity. In obese children, lifestyle interventions are able to lower inflammation and reduce cardiovascular risk factors associated with obesity. The aim of the present work was to study changes in inflammation‐related molecules serum and peripheral blood mononuclear cells (PBMC) transcript levels after a 10‐week lifestyle intervention in obese children and asses their potential association with glucose metabolism. Methods: Twenty‐three obese children (mean age 11.5 years; 48% males) underwent a 10‐week lifestyle not controlled intervention trial. Anthropometric and biochemical measurements were analyzed. Transcript analysis for CT‐1, IL‐6, and TNF‐α in PBMC were performed by RT‐PCR. Serum cytokine levels were also measured at baseline and after 10‐weeks. Results: Participants achieved a significant reduction in body adiposity (0.34 decrease in body mass index‐standard deviation), total cholesterol, and glucose levels after 10‐weeks. A Significant decrease in serum TNF‐α and C reactive protein (CRP) were observed. CT‐1 transcript levels were significantly reduced (P = .005) after lifestyle intervention, and these changes were significantly correlated with changes in serum CT‐1 levels (r = 0.451; P = .031). In multiple regression analysis baseline CT‐1 transcript levels were positively associated with final insulin (R2 = 0.506; P = .035) and HOMA‐IR values (R2 = 0.473; P = .034). Conclusions: We reported that serum CRP, TNF‐α, as well as PBMC CT‐1 transcript levels were reduced after lifestyle intervention in obese children. More studies are needed to clarify the role of inflammation‐related molecules in glucose metabolism. [ABSTRACT FROM AUTHOR]