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1. Structural Basis for the Interaction between Tankyrase-2 and a Potent Wnt-Signaling Inhibitor.

Author

Tobias Karlberg, Natalia Markova, Ida Johansson, Martin Hammarström, Patrick Schütz, Johan Weigelt, and Herwig Schüler

Subjects
*DRUG interactions, *WNT proteins, *ENZYME inhibitors, *CELLULAR signal transduction, *ADP-ribosyltransferases, *HOMEOSTASIS, *TELOMERES, *MOLECULAR structure
Abstract

We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. The complex of TNKS2 with the potent inhibitor XAV939 provides insights into the molecular basis of the strong interaction and suggests routes for further development of tankyrase inhibitors. [ABSTRACT FROM AUTHOR]

Published
2010
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