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1. Beyond Thermodynamics: Drug Binding Kinetics Could Influence Epidermal Growth Factor Signaling.

Author

Mayank Goyal, Michael Rizzo, Frank Schumacher, and Chung F. Wong

Subjects
*THERMODYNAMICS, *DRUG efficacy, *EPIDERMAL growth factor, *DRUG carriers, *PROTEIN kinases, *LUNG cancer, *CELLULAR signal transduction
Abstract

We modeled the kinetics of drug binding to protein kinases in the EGF signaling pathway relevant to non-small-cell lung cancer and found that binding kinetics could influence therapeutic potential, that fast binding kinetics was advantageous for most targets with a couple of exceptions, that targeting some protein kinases could enhance rather than attenuate the pathway, and that IC50could be sensitive to the kinetic parameters of drug binding. [ABSTRACT FROM AUTHOR]

Published
2009
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