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1. Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology.

Author

Koyo Tsujikawa, Kohei Hamana, Yuichi Riku, Yuki Hattori, Norikazu Hara, Yohei Iguchi, Shinsuke Ishigaki, Atsushi Hashizume, Satoko Miyatake, Satomi Mitsuhashi, Yu Miyazaki, Mayumi Kataoka, Li Jiayi, Keizo Yasui, Satoshi Kuru, Haruki Koike, Kenta Kobayashi, Naruhiko Sahara, Norio Ozaki, and Mari Yoshida

Subjects
*NEUROFIBRILLARY tangles, *TAU proteins, *PROGRESSIVE supranuclear palsy, *MICROFILAMENT proteins, *RNA-binding proteins, *GREEN fluorescent protein, *DARDARIN
Abstract

The article discusses that amyloid-B lies upstream of tau pathology in Alzheimer's disease, but key drivers for other tauopathies, including progressive supranuclear palsy (PSP), are unknown. Various tau mutations facilitate tau aggregation, but how the nonmutated tau, with PSP share, increases its propensity to aggregate in neurons and glial cells has remained elusive.

Published
2022
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