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Abstract: Starting with a high-throughput screening lead, a novel series of CCR5 antagonists was developed utilizing an information-based approach. Improvement of pharmacokinetic properties for the series was pursued by SAR exploration of the lead template. The synthesis, SAR and biological profiles of the series are described. [Copyright &y& Elsevier]

Reports on the synthesis of model compounds related to the proposed structure of Aspergillus niger amine oxidase. Characterization of the redox properties of the model compound and spectral properties of its 4-nitrophenylhydrazine derivative; Misidentification of cofactor in A. niger amine oxidase as a functional quino-cofactor.

Reports on the biosynthesis of 4-hydroxy-3-nitrosobenzamide in Streptomyces murayamaensis mutants MC2 and MC using sodium [1,2-13C2]- and [1-13C,18O2]acetate, sodium [2,3-13C2]succinate, [1,2-13C2]glutamic acid, [4,13C]aspartic acid, and sodium [1-13C]- and [2,3-13C2]pyruvate. Subsequent specific incorporations of acids.

Describes the biosynthesis of the benzo[b]fluorene antibiotic, Kinamycin D. Isolation of aminobenzo[b]fluorene, stealthin C from Streptomycis murayamaensis culture; Incorporation of stealthin C into kinamycin D; Reaction mechanisms.