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A multicentric study conducted in northern Italy explored the potential link between atopic dermatitis (AD) and cardiovascular diseases (CVD) in young patients (<40 years). The study found that 8% of AD patients had CVD, with 28% of those patients being under 40 years old. The main CVD observed in young AD patients were paroxysmal supraventricular tachycardia (PSVT), atrial fibrillation (AF), and high burden of atrial ectopies (AE). The study suggests that chronic inflammation and psycho-physical stress associated with AD may contribute to the development of CVD in young patients. However, larger cohorts are needed to further investigate this association. [Extracted from the article]

Atopic dermatitis (AD) is a chronic inflammatory disease that may involve any cutaneous site; involvement of the genital area may greatly impair patients' quality of life but, as the inspection of genitals is not usually conducted during the routine physical examination of patients with AD, the genital presentation of AD is frequently neglected and under-reported. We decided to evaluate the incidence of genital AD in patients with moderate-severe AD and the relative response to anti-interleukin (IL)-4/IL-13 dupilumab. GLO:DF2/01jan22:ced14894-toc-0001.jpg PHOTO (COLOR): . gl Dear Editor, Atopic dermatitis (AD) is a chronic inflammatory disease that may involve any cutaneous site, including the genital area. [Extracted from the article]

The median age of patients with UM with eCAs was slightly lower (63 years) than that of patients with UM with no eCAs (66 years), even though the means were similar between the two groups (mean ± SD 63 ± 9.9 for the eCA groups vs. 64 ± 12.3 for the no-eCA group) (Fig. Sixteen patients (49%) had TNN > 10, and the proportion of patients with TNN > 10 was lower in the group with UM and eCAs than in the group with UM and no eCAs ( I P i < 0.01) (Fig. In previous studies, a clinical association between eruptive cherry angiomas (eCAs) and cutaneous malignancies has been found.1,2The presence of both lesions in the same individuals may suggest a shared pathophysiology between eCAs and other tumours.2 While the association of eCAs with cutaneous melanoma has been well established, the rate of association with other rare melanocytic malignancies, such as uveal melanoma (UM) has not been yet explored. [Extracted from the article]

We found higher levels of ST in patients with scalp psoriasis than in those without (6.1 vs. 4.6 ng/mL), in those with palmoplantar psoriasis than in those without (5.3 vs. 5 ng/mL) and in those with psoriatic arthritis than in those without (6.1 vs. 5.1 ng/mL) (Fig. We found higher levels of ST in patients with scalp psoriasis than in those without (6.1 vs. 4.6 ng/mL), in those with palmoplantar psoriasis than in those without (5.3 vs. 5 ng/mL) and, with less significance, in those with psoriatic arthritis than in those without (6.1 vs. 5.1 ng/mL). In psoriasis, biomarkers for disease prognosis and response to treatment may help clinicians to improve patient management. [Extracted from the article]

Background Granulomatous reaction is a well-known complication following soft filler procedures. However, the diagnosis of filler-induced granulomas may be challenging because of the occasional reluctance of patients to report the previously performed aesthetic procedure. Objective To describe a new clinical situation in which some patients, in the quest for physical perfection, become addicted to multiple sequential cosmetic injections, increasing the risk of adverse reactions. Methods We describe three women who developed diffuse facial nodular tumefaction after multiple procedures of filler injections into their face that occurred at different times in the previous years. Results Histopathology showed a granulomatous reaction including different combined substances that were identified with different types of micro-implants in the same biopsy. Conclusions Excessive demand of multiple cosmetic injections may increase the frequency of skin granulomatous reactions and can be included in the spectrum of similar addictive dysmorphophobic behaviours. Histopathology is the best mean to achieve the diagnosis. [ABSTRACT FROM AUTHOR]

Tuberous sclerosis ( TS) is a genodermatosis characterized by facial angiofibromas ( FAs). These tumours cause aesthetic disfigurement and obstruction of vision, and haemorrhage when traumatized, which can lead to emotional distress and relationship difficulties. We report the case of a 35-year-old patient with extensive TS-associated FAs that were treated with an ultrapulse carbon dioxide laser ( UPCDL). UPCDL laser seems to be a easy, useful and convenient tool for the treatment of nodular FAs, which provides good aesthetic results, and a positive response from patients, who report high levels of satisfaction with the results. Minimal recurrence of the tumours occurred during long-term follow-up, and these were successfully treated with UPCDL. It is not yet possible to correct the genetic alterations underlying TS, but UPCDL treatment is a convenient tool to improve the facial appearance of patients with severe FAs. [ABSTRACT FROM AUTHOR]