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Background: Malaria is one of the most common infectious and fatal diseases worldwide. Quinine sulfate is one of the antimalarial drug used to treat chloroquine resistant malaria and malaria falciparum. Aims and Objectives: The present study was designed to assess its developmental defects on mice palate. Materials and Methods: Thirty adult pregnant female Swiss albino mice were used in the present work. They were divided into five groups of six each. One control group (c) with 6 pregnant mice received normal saline orally from day 6 to 15 of gestation. Four treated groups of 6 pregnant mice each were formed. Treated groups T1, T2, T3 and T4 were administered Quinine sulfateorally with 50, 100, 200, 400 mg/kg bw/day from day 6 to 15 of gestation respectively. Results: No palatal abnormalities were observed histologically in the control and T1 treated group. However, varying degrees of clefting of the palate, from failure of elevation of the palatal shelves to failure of fusion in the midline were observed in the Quinine sulfate treated groups (T2, T3 & T4). Conclusion: Quinine sulfate induced defects in the developing palate in the present study by disturbing the process of palatogenesis, which is characterized by incomplete growth, elevation or fusion of the palatal shelves. [ABSTRACT FROM AUTHOR]