1. Polarizable Force Field with a σ-Holefor Liquid and Aqueous Bromomethane.
- Author
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ArchitaN. S. Adluri, Jennifer N. Murphy, Tiffany Tozer, and Christopher N. Rowley
- Subjects
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MOLECULAR dynamics , *BROMOMETHANE , *POLLUTANTS , *OZONE layer depletion , *LIQUID-vapor interfaces - Abstract
Bromomethane(CH3Br) is an acutely toxic environmentalpollutant that contributes to ozone depletion. Molecular simulationcould be a valuable tool for studying its partitioning and transportin the environment if an accurate molecular model was available. Thegeneralized Amber force field (GAFF), OPLS (optimized potentials forliquid simulations) force field, and CHARMM general force field (CGenFF)were tested for their ability to model the physical properties ofliquid bromomethane. The OPLS force field was in fairly good agreementwith experiment, while CGenFF and GAFF were significantly in error.The Br Lennard-Jones parameters of the GAFF and CGenFF models werereparameterized, but their radial distribution functions still havesignificant deviations from those calculated by ab initio moleculardynamics (AIMD). A Drude polarizable force field for bromomethanewas parametrized with an off-center positively charged site to representthe C–Br σ-hole. This model is in good agreement withthe bulk physical properties and the AIMD RDFs. The modest solubilityof bromomethane was reproduced by this model, with dispersion interactionsbeing the dominant water–solute interaction. The water–soluteelectrostatic interactions are a smaller factor in solubility. Thismodel predicts bromomethane to have a 13 kJ mol–1surface excess potential at the water–vapor interface. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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