1. Accumulibacter spp. as the origin of the OXA-198 carbapenemase gene cassette.
- Author
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Jacquemin, Aymeric, Naas, Thierry, Dortet, Laurent, and Bonnin, Rémy A
- Subjects
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CARBAPENEMASE , *MOBILE genetic elements , *GENES - Abstract
This article discusses the discovery of the OXA-198 carbapenemase gene cassette in the genus Candidatus Accumulibacter. The Candidatus Accumulibacter genus is known for its role in enhanced biological phosphate removal in wastewater treatment. The OXA-198 gene was first identified in clinical Pseudomonas aeruginosa isolates and later in Enterobacterales. The study found that the blaOXA-198-like gene was present in three different regions of Denmark, but unfortunately, the isolates were not cultivated. The genetic contexts of the blaOXA-198-like genes were analyzed, and it was determined that they were not acquired from other sources. The study suggests that Candidatus Accumulibacter may be the progenitor of OXA-198-like carbapenemase-encoding genes. This finding is significant as it provides insight into the origins of carbapenemase genes and may aid in future research and prevention efforts. [Extracted from the article]
- Published
- 2024
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