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Edward Reynolds Hun is easily eclipsed by his father, Thomas (1808–1896), and his younger brother, Henry (1854–1924), in historical accounts of the evolution of neurology as a clinical specialty and academic discipline in nineteenth-century America. His early educational pathway, including a postgraduate year in Paris, was typical for sons of the wealthy seeking a medical degree. On his return from Europe, he embarked on a research career in neuropsychiatry seeking to uncover biochemical and pathological underpinnings for psychiatric disorders. In addition to standard postmortem examinations, he used the most up-to-date technological advances such as sphygmography. He was also one of the first Americans to publish photomicrographs of muscle obtained by biopsy. In his mid-30s he became a charter member of the American Neurological Association and was appointed professor of diseases of the nervous system at Albany Medical College. His health then rapidly deteriorated, leading to his early death at age 37 of an unclear neurologic disorder. His career intersected with those of other notables in late-nineteenth-century American neurology, including John P. Gray, William A. Hammond, Edward Constant Séguin, and Edward Charles Spitzka. [ABSTRACT FROM AUTHOR]

This article explores two questions: (1) whether portable MRI research might escape regulatory oversight altogether under existing U.S. privacy and research ethical frameworks, leaving research participants without adequate protections, and (2) whether existing regulatory frameworks, when they do apply, can guard society's broader interest in ensuring that portable MRI research pursues socially beneficial, ethically sound aims that minimize the potential for externalities affecting nonparticipating individuals and groups, who might be stigmatized or otherwise harmed even if they decline participation in the research. [ABSTRACT FROM AUTHOR]

Background Objective Methods Results Conclusion Understanding the neural mechanisms underlying migraine and other primary headache disorders is critical for the development of long‐term cures. Magnetoencephalography (MEG), an imaging modality that measures neuronal currents and cortical excitability with high temporal and superior spatial resolution, has been increasingly used in neurological research. Initial MEG studies showed promise in directly recording cortical spreading depression—a cortical correlate of migraine with aura. However, lately MEG technology has highly evolved with greater potential to reveal underlying pathophysiology of migraine and primary headache disorders, and aid in the identification of biomarkers.To systematically review the use of MEG in migraine and other primary headache disorders and summarize findings.We conducted a systematic search and selection of MEG studies in migraine and primary headache disorders from inception until June 8, 2023, in Medline, Embase, Cochrane, and Scopus databases. Peer‐reviewed English articles reporting the use of MEG for clinical or research purposes in migraine and primary headache disorders were selected.We found 560 articles and included 38 in this review after screening. Twelve studies investigated resting‐state, while others investigated a sensory modality using an evoked or event‐related paradigm with a total of 35 cohort and 3 case studies. Thirty‐two studies focused exclusively on migraine, while the rest reported other primary headache disorders.The findings show an evolution of MEG from a 7‐ to a 306‐channel system and analysis evolving from sensor‐level evoked responses to more advanced source‐level connectivity measures. A relatively few MEG studies portrayed migraine and primary headache disorders as a sensory abnormality, especially of the visual system. We found heterogeneity in the datasets, data reporting standards (due to constantly evolving MEG technology and analysis methods), and patient characteristics. Studies were inadequately powered and there was no evidence of blinding procedures to avoid selection bias in case–control studies, which could have led to false‐positive findings. More studies are needed to investigate the affective–cognitive aspects that exacerbate pain and disability in migraine and primary headache disorders. [ABSTRACT FROM AUTHOR]

Objectives: A deep knowledge of the surgical anatomy of the target area is mandatory for a successful operative procedure. For this purpose, over the years, many teaching and learning methods have been described, from the most ancient cadaveric dissection to the most recent virtual reality, each with their respective pros and cons. Photogrammetry, an emergent technique, allows for the creation of three-dimensional (3D) models and reconstructions. Thanks to the spreading of photogrammetry nowadays it is possible to generate these models using professional software or even smartphone apps. This study aims to compare the neuroanatomical photogrammetric models generated by the two most utilized smartphone applications in this domain, Metascan and 3D-Scanner, through quantitative analysis. Methods: Two human head specimens (four sides) were examined. Anatomical dissection was segmented into five stages to systematically expose well-defined structures. After each stage, a photogrammetric model was generated using two prominent smartphone applications. These models were then subjected to both quantitative and qualitative analysis, with a specific focus on comparing the mesh density as a measure of model resolution and accuracy. Appropriate consent was obtained for the publication of the cadaver's image. Results: The quantitative analysis revealed that the models generated by Metascan app consistently demonstrated superior mesh density compared to those from 3D-Scanner, indicating a higher level of detail and potential for precise anatomical representation. Conclusion: Enabling depth perception, capturing high-quality images, offering flexibility in viewpoints: photogrammetry provides researchers with unprecedented opportunities to explore and understand the intricate and magnificent structure of the brain. However, it is of paramount importance to develop and apply rigorous quality control systems to ensure data integrity and reliability of findings in neurological research. This study has demonstrated the superiority of Metascan in processing photogrammetric models for neuroanatomical studies. [ABSTRACT FROM AUTHOR]

Background: Neurological disorders have had a substantial rise the last three decades, imposing substantial burdens on both patients and healthcare costs. Consequently, the demand for high-quality research has become crucial for exploring effective treatment options. However, current neurology research has some limitations in terms of transparency, reproducibility, and reporting bias. The adoption of reporting guidelines (RGs) and trial registration policies has been proven to address these issues and improve research quality in other medical disciplines. It is unclear the extent to which these policies are being endorsed by neurology journals. Therefore, our study aims to evaluate the publishing policies of top neurology journals regarding RGs and trial registration. Methods: For this cross-sectional study, neurology journals were identified using the 2021 Scopus CiteScore Tool. The top 100 journals were listed and screened for eligibility for our study. In a masked, duplicate fashion, investigators extracted data on journal characteristics, policies on RGs, and policies on trial registration using information from each journal's Instruction for Authors webpage. Additionally, investigators contacted journal editors to ensure information was current and accurate. No human participants were involved in this study. Our data collection and analyses were performed from December 14, 2022, to January 9, 2023. Results: Of the 356 neurology journals identified, the top 100 were included into our sample. The five-year impact of these journals ranged from 50.844 to 2.226 (mean [SD], 7.82 [7.01]). Twenty-five (25.0%) journals did not require or recommend a single RG within their Instructions for Authors webpage, and a third (33.0%) did not require or recommend clinical trial registration. The most frequently mentioned RGs were CONSORT (64.6%), PRISMA (52.5%), and ARRIVE (53.1%). The least mentioned RG was QUOROM (1.0%), followed by MOOSE (9.0%), and SQUIRE (17.9%). Conclusions: While many top neurology journals endorse the use of RGs and trial registries, there are still areas where their adoption can be improved. Addressing these shortcomings leads to further advancements in the field of neurology, resulting in higher-quality research and better outcomes for patients. [ABSTRACT FROM AUTHOR]

Background: Bone‐derived protein osteocalcin, which has beneficial effects on brain function, may be a future research direction for neurological disorders. A growing body of evidence suggests a link between osteocalcin and neurological disorders, but the exact relationship is contradictory and unclear. Scope of Review: The aim of this review is to summarize the current research on the interaction between osteocalcin and the central nervous system and to propose some speculative future research directions. Major Conclusions: In the normal central nervous system, osteocalcin is involved in neuronal structure, neuroprotection, and the regulation of cognition and anxiety. Studies on osteocalcin‐related abnormalities in the central nervous system are divided into animal model studies and human studies, depending on the subject. In humans, the link between osteocalcin and brain function is inconsistent. These conflicting data may be due to methodological inconsistencies. By reviewing the related literature on osteocalcin, some comorbidities of the bone and nervous system and future research directions related to osteocalcin are proposed. [ABSTRACT FROM AUTHOR]

Neuroprotection aims to safeguard neurons from damage caused by various factors like stress, potentially leading to the rescue, recovery, or regeneration of the nervous system and its functions [J Clin Neurosci. 2002;9(1):4–8]. Conversely, neuroplasticity refers to the brain's ability to adapt and change throughout life, involving structural and functional alterations in cells and synaptic transmission [Neural Plast. 2014;2014:541870]. Neuroprotection is a broad and multidisciplinary field encompassing various approaches and strategies aimed at preserving and promoting neuronal health. It is a critical area of research in neuroscience and neurology, with the potential to lead to new therapies for a wide range of neurological disorders and conditions. Neuroprotection can take various forms and may involve pharmacological agents, lifestyle modifications, or behavioral interventions. Accordingly, also the perspective and the meaning of neuroprotection differs due to different angles of interpretation. The primary interpretation is from the pharmacological point of view since the most consistent data come from this field. In addition, we will discuss also alternative, yet less considered, perspectives on neuroprotection, focusing on specific neuroprotective targets, interactions with surrounding microglia, different levels of neuroprotective effects, the reversive/adaptative dimension, and its use as anticipatory/prophylactic intervention. [ABSTRACT FROM AUTHOR]

The quality and quantity of clozapine safety monitoring considerably differs among South American countries and mainly focus on hematological surveillance. Few studies have been conducted on other clozapine-related adverse effects (ADRs) and mainly refer to case reports and literature reviews. We retrieved thirty-nine publications on clozapine related ADRs others than neutropenia. Studies in Brazil and Venezuela accounted for 67 % of all the publications, and 8 out of 12 countries published 2 or less manuscripts. Only Chile offers serum clozapine level measurement in public institutions. Given the recently recognized role of ethnicity, gender, smoking, obesity drug interactions in optimal clozapine administration, modernization of clozapine clinical use and research in psychiatry and neurology most be broadcasted and stimulated in South American countries. [ABSTRACT FROM AUTHOR]

Handedness, a complex human aspect that reflects the functional lateralization of the hemispheres, also interacts with the immune system. This study aimed to expand the knowledge of the lateralization of hand, foot, and eye activities in patients with immune-mediated (IM) or other (noIM) neurological diseases and to clarify the properties of the Edinburgh Handedness Inventory (EHI) in an Italian population. Three hundred thirty-four patients with IM or noIM diseases affecting the brain or spine and peripheral nervous system were interviewed about stressful events preceding the disease, subjective handedness, and familiarity for left-handedness or ambidexterity. The patients and 40 healthy subjects underwent EHI examination. In the whole group of participants, 24 items of the EHI were classified into five factors (Hand Transitive, Hand Refined, Hand Median, Foot, Eye), demonstrating good reliability and validity. Chronological age had a significant influence on hand and foot EHI factors and the laterality quotient (LQ), particularly on writing and painting. In the patient groups, EHI factors and the LQ were also predicted by age of disease onset, duration of disease, and family history of left-handedness or ambidexterity. No differences were found between patients and healthy subjects, but pencil use scored significantly lower in patients with IM diseases than in those with noIM brain diseases. These results demonstrate that the lateralization of hand and foot activities is not a fixed human aspect, but that it can change throughout life, especially for abstract and symbolic activities. Chronic neurological diseases can cause changes in handedness. This may explain why, unlike systemic immunological diseases, IM neurological diseases are not closely associated with left-handedness. In these patients, the long version of the EHI is appropriate for determining the lateralization of body activities to contextualize the neurological picture; therefore, these findings extend the Italian normative data sets. [ABSTRACT FROM AUTHOR]

Neurological conditions are the leading cause of disability and mortality combined, demanding innovative, scalable, and sustainable solutions. Brain health has become a global priority with adoption of the World Health Organization's Intersectoral Global Action Plan in 2022. Simultaneously, rapid advancements in artificial intelligence (AI) are revolutionizing neurological research and practice. This scoping review of 66 original articles explores the value of AI in neurology and brain health, systematizing the landscape for emergent clinical opportunities and future trends across the care trajectory: prevention, risk stratification, early detection, diagnosis, management, and rehabilitation. AI's potential to advance personalized precision neurology and global brain health directives hinges on resolving core challenges across four pillars—models, data, feasibility/equity, and regulation/innovation—through concerted pursuit of targeted recommendations. Paramount actions include swift, ethical, equity-focused integration of novel technologies into clinical workflows, mitigating data-related issues, counteracting digital inequity gaps, and establishing robust governance frameworks balancing safety and innovation. [ABSTRACT FROM AUTHOR]

Underserved and underrepresented populations have historically been excluded from neurological research. This lack of representation has implications for translation of research findings into clinical practice given the impact of social determinants of health on neurological disease risk, progression, and outcomes. Lack of inclusion in research is driven by individual-, investigator-, and study-level barriers as well as larger systemic injustices (e.g., structural racism, discriminatory practices). Although strategies to increase inclusion of underserved and underrepresented populations have been put forth, numerous questions remain about the most effective methodology. In this article, we highlight inclusivity patterns and gaps among the most common neurological conditions and propose best practices informed by our own experiences in engagement of local community organizations and collaboration efforts to increase underserved and underrepresented population participation in neurological research. [ABSTRACT FROM AUTHOR]

The advent of Induced Pluripotent Stem Cells (iPSCs) has revolutionized neuroscience research. This groundbreaking innovation has facilitated the development of three-dimensional (3D) neural organoids, which closely mimicked the intricate structure and diverse functions of the human brain, providing an unprecedented platform for the in-depth study and understanding of neurological phenomena. However, these organoids lack key components of the neural microenvironment, particularly immune cells like microglia, thereby limiting their applicability in neuroinflammation research. Recent advancements focused on addressing this gap by integrating iPSC-derived microglia into neural organoids, thereby creating an immunized microenvironment that more accurately reflects human central neural tissue. This review explores the latest developments in this field, emphasizing the interaction between microglia and neurons within immunized neural organoids and highlights how this integrated approach not only enhances our understanding of neuroinflammatory processes but also opens new avenues in regenerative medicine. [ABSTRACT FROM AUTHOR]

The rapidly accelerating translation of biomedical advances is leading to revolutionary therapies that are often inaccessible to historically marginalized populations. We identified and synthesized recent guidelines and statements to propose 7 strategies to integrate equity within translational research in neurology: (1) learn history; (2) learn about upstream forces; (3) diversify and liberate; (4) change narratives and adopt best communication practices; (5) study social drivers of health and lived experiences; (6) leverage health technologies; and (7) build, sustain, and lead culturally humble teams. We propose that equity should be a major goal of translational research, equally important as safety and efficacy. ANN NEUROL 2024;95:432–441 [ABSTRACT FROM AUTHOR]

Sex, sexuality, and gender diversity is understudied and underserved in neurology. Neurology research inclusive of LGBTQIA+ (lesbian, gay, bisexual, transgender, queer, intersex, asexual) people is limited. Existing research struggles with a paucity of neurology studies collecting sex, sexuality, and gender diverse (SSGD) data, conflation of sex and gender, lack of precision in measures, neglect of younger and older populations, nebulous benefit to community, and absent intersectionality. Future directions in SSGD neurology research include precise and community‐based measurements, respect for LGBTQIA+ colleagues, and the application of minority stress models. All patients stand to benefit from research that elucidates how SSGD variables influence neurological health. ANN NEUROL 2024;95:421–431 [ABSTRACT FROM AUTHOR]

Background and purpose: Neurological disorders constitute a significant portion of the global disease burden, affecting >30% of the world's population. This prevalence poses a substantial threat to global health in the foreseeable future. A lack of awareness regarding this high burden of neurological diseases has led to their underrecognition, underappreciation, and insufficient funding. Establishing a strategic and comprehensive research agenda for brain‐related studies is a crucial step towards aligning research objectives among all pertinent stakeholders and fostering greater societal awareness. Methods: A scoping literature review was undertaken by a working group from the European Academy of Neurology (EAN) to identify any existing research agendas relevant to neurology. Additionally, a specialized survey was conducted among all EAN scientific panels, including neurologists and patients, inquiring about their perspectives on the current research priorities and gaps in neurology. Results: The review revealed the absence of a unified, overarching brain research agenda. Existing research agendas predominantly focus on specialized topics within neurology, resulting in an imbalance in the number of agendas across subspecialties. The survey indicated a prioritization of neurological disorders and research gaps. Conclusions: Building upon the findings from the review and survey, key components for a strategic and comprehensive neurological research agenda in Europe were delineated. This research agenda serves as a valuable prioritization tool for neuroscientific researchers, as well as for clinicians, donors, and funding agencies in the field of neurology. It offers essential guidance for creating a roadmap for research and clinical advancement, ultimately leading to heightened awareness and reduced burden of neurological disorders. [ABSTRACT FROM AUTHOR]

Ludwig Edinger (1855–1918) is often perceived as a functional neuroanatomist who primarily followed traditional lines of microscopic research. That he was a rather fascinating innovator in the history of neurology at the turn from the nineteenth to the twentieth century has, however, gone quite unnoticed. Edinger's career and his pronounced hopes for future investigative progress in neurological work mark an important shift, one away from traditional research styles connected to department-based approaches towards a multi-perspective and quite advanced form of interdisciplinary scientific work. Being conceptually influenced by the Austrian neuroanatomist Heinrich Obersteiner (1847–1922) and his foundation of the Neurological Institute in Vienna in 1882, Edinger established a multi-faceted brain research program. It was linked to an institutional setting of laboratory analysis and clinical research that paved the way for a new type of interdisciplinarity. After completion of his medical training, which brought him in working relationships with illustrious clinicians such as Friedrich von Recklinghausen (1810–1879) and Adolf Kussmaul (1822–1902), Edinger settled in 1883 as one of the first clinically working neurologists in the German city of Frankfurt/Main. Here, he began to collaborate with the neuropathologist Carl Weigert (1845–1904), who worked at the independent research institute of the Senckenbergische Anatomie. Since 1902, Edinger came to organize the anatomical collections and equipment for a new brain research laboratory in the recently constructed Senckenbergische Pathologie. It was later renamed the "Neurological Institute", and became an early interdisciplinary working place for the study of the human nervous system in its comparative, morphological, experimental, and clinical dimensions. Even after Edinger's death and under the austere circumstances of the Weimar Period, altogether three serviceable divisions continued with fruitful research activities in close alignment: the unit of comparative neurology, the unit of neuropsychology and neuropathology (headed by holist neurologist Kurt Goldstein, 1865–1965), and an associated unit of paleoneurology (chaired by Ludwig Edinger's daughter Tilly, 1897–1967, who later became a pioneering neuropaleontologist at Harvard University). It was especially the close vicinity of the clinic that attracted Edinger's attention and led him to conceive a successful model of neurological research, joining together different scientific perspectives in a unique and visibly modern form. [ABSTRACT FROM AUTHOR]

Background: To assess the state of neurological scientific research in Italy in the time interval 2020–2023. Methods: Elsevier's modular integrated platform "SciVal" was used to analyze bibliometric research products starting from scientific production data uploaded onto Scopus. We considered the research area "Neurology" in the 01/01/2020–14/06/2023 time interval, and the following variables were extracted: number of published studies, number of citations, Field-Weighted Citation Impact, and percentage of international collaborations. The contribution of Italian scientists to the neurological research was compared to that of the other nations. Results: Research identified 90,633 scientific papers in the neurological area worldwide, with a total of 472,750 citations. The products assigned to Italian groups were 6670 (53,587 citations, Field-Weighted Citation Impact 1.68, 41% international collaborations). Conclusions: According to the present study, Italian neurological research 2020 to 2023 ranks fifth globally and third in Europe. [ABSTRACT FROM AUTHOR]

Background: Neurological disorders remain a worldwide concern due to their increasing prevalence and mortality, combined with the lack of available treatment, in most cases. Exploring protective and risk factors associated with the development of neurological disorders will allow for improving prevention strategies. However, ascertaining neurological outcomes in population-based studies can be both complex and costly. The application of eHealth tools in research may contribute to lowering the costs and increase accessibility. The aim of this systematic review is to map existing eHealth tools assessing neurological signs and/or symptoms for epidemiological research. Methods: Four search engines (PubMed, Web of Science, Scopus & EBSCOHost) were used to retrieve articles on the development, validation, or implementation of eHealth tools to assess neurological signs and/or symptoms. The clinical and technical properties of the software tools were summarised. Due to high numbers, only software tools are presented here. Findings: A total of 42 tools were retrieved. These captured signs and/or symptoms belonging to four neurological domains: cognitive function, motor function, cranial nerves, and gait and coordination. An additional fifth category of composite tools was added. Most of the tools were available in English and were developed for smartphone device, with the remaining tools being available as web-based platforms. Less than half of the captured tools were fully validated, and only approximately half were still active at the time of data collection. Interpretation: The identified tools often presented limitations either due to language barriers or lack of proper validation. Maintenance and durability of most tools were low. The present mapping exercise offers a detailed guide for epidemiologists to identify the most appropriate eHealth tool for their research. Funding: The current study was funded by a PhD position at the University of Groningen. No additional funding was acquired. [ABSTRACT FROM AUTHOR]

This document contains abstracts from various articles and workshops related to brain impairment and neurological research. The articles cover topics such as the association between traumatic brain injury (TBI) and mental health outcomes, the impact of brain atrophy on interoception and emotion recognition, and the volumetric trajectories of amygdala subnuclei in frontotemporal dementia. The workshops focus on engaging with First Nations communities, technological interventions for cognitive impairments, reducing emotion dysregulation after brain injury, and understanding ADHD symptoms and interventions. The articles and workshops provide valuable insights into disability and rehabilitation, highlighting the need for improved support and inclusion. [Extracted from the article]

This document emphasizes the significance of translational research in understanding and treating neurological and psychiatric diseases. It discusses the importance of in vivo and in vitro models in studying the complex mechanisms of these conditions. The document also highlights the role of sex/gender and aging in the development of neuropsychiatric disorders. The research topic includes 25 papers that cover various topics, such as novel preclinical models, research techniques, and the potential of stem-cell-based therapies. These papers provide valuable insights into the underlying pathology of neurological and psychiatric diseases and offer potential avenues for new treatments. The document also discusses the importance of preclinical models in advancing research on these disorders, identifying potential biomarkers, and discovering innovative treatments. It emphasizes the role of neuropharmacological research in developing therapeutic agents and the significance of advanced imaging techniques in studying brain structure and function. The ultimate goal is to improve the quality of life for individuals with these complex mental health conditions through personalized care and support. [Extracted from the article]

Over the past 20 years, several eye-tracking technologies have been developed. This article aims to present a new type of eye tracker capable of producing detailed information on eye and head movements using an array of magnetoresistive detectors fixed on the patient's head and a small magnet inserted into a contact lens, adapted to the curvature of the cornea of the subject. The software used for data analysis can combine or compare eye and head movements and can represent them as 2D or 3D images. Preliminary data involve an initial patient who was asked to perform several tasks to establish the accuracy, reliability, and tolerance of the magnetic eye tracker and software. The tasks included assessment of saccadic eye movements and pursuit, "drawing" alphabetic shapes or letters, and reading. Finally, a Head Impulse Test (HIT) was performed to estimate the VOR gain, comparing the standard deviation established via vHIT with that established via this magnetic eye tracker (mHIT). This prototypical device is minimally invasive, lightweight, relatively cheap, and tolerable, with a high degree of reliability and precision. All these characteristics could lead to the future use of the magnetic eye tracker in neurological and otoneurological fields. [ABSTRACT FROM AUTHOR]

In this study, I use a representative survey from the German Twin Family Panel (N = 5,472) to examine the extent to which genetic and environmental factors account for time spent playing video games on personal computers and gaming consoles. Results show that genetic variation among twins explains a non-trivial amount of variation in video game play. Through ACE modeling techniques, I find that between 25% to 39% of the total variance in time spent playing video games can be attributed to shared genetic traits with the remainder explained by shared environmental factors (e.g., parenting and culture) and environmental attributes unique to individuals. This study and its findings provide a starting point for future genetic and neurological research on video game use and effects. [ABSTRACT FROM AUTHOR]

A major challenge in brain organoid technologies is the lack of vasculature. In recent years, innovative approaches have been taken to meet this challenge. A 2020 paper published in PLOS Biology exemplifies the approaches used in this booming field. The development of brain organoids has been a boon to neurological research, but working out how to add blood vessels to organoids has posed a challenge. This Perspective looks at innovative approaches to brain organoid vascularization, including those put forward in a 2020 PLOS Biology paper. [ABSTRACT FROM AUTHOR]

The development of the brain sciences (Hirnforschung) in the Max Planck Society (MPG) during the early decades of the Federal Republic of Germany (FRG) was influenced by the legacy of its precursor institution, the Kaiser Wilhelm Society for the Advancement of Science (KWG). The KWG's brain science institutes, along with their intramural psychiatry and neurology research programs, were of considerable interest to the Western Allies and former administrators of the German science and education systems in their plans to rebuild the extra-university research society—first in the British Occupation Zone and later in the American and French Occupation Zones. This formation process occurred under the physicist Max Planck (1858–1947) as acting president, and the MPG was named in his honor when it was formally established in 1948. In comparison to other international developments in the brain sciences, it was neuropathology as well as neurohistology that initially dominated postwar brain research activities in West Germany. In regard to its KWG past, at least four historical factors can be identified that explain the dislocated structural and social features of the MPG during the postwar period: first, the disruption of previously existing interactions between German brain scientists and international colleagues; second, the German educational structures that countered interdisciplinary developments through their structural focus on medical research disciplines during the postwar period; third, the moral misconduct of earlier KWG scientists and scholars during the National Socialism period; and, fourth, the deep rupture that appeared through the forced migration of many Jewish and oppositional neuroscientists who sought to find exile after 1933 in countries where they had already held active collaborations since the 1910s and 1920s. This article examines several trends in the MPG's disrupted relational processes as it sought to grapple with its broken past, beginning with the period of reinauguration of relevant Max Planck Institutes in brain science and culminating with the establishment of the Presidential Research Program on the History of the Kaiser Wilhelm Society in National Socialism in 1997. [ABSTRACT FROM AUTHOR]

Nervous system diseases present significant challenges to the neuroscience community due to ethical and practical constraints that limit access to appropriate research materials. Somatic cell reprogramming has been proposed as a novel way to obtain neurons. Various emerging techniques have been used to reprogram mature and differentiated cells into neurons. This review provides an overview of somatic cell reprogramming for neurological research and therapy, focusing on neural reprogramming and generating different neural cell types. We examine the mechanisms involved in reprogramming and the challenges that arise. We herein summarize cell reprogramming strategies to generate neurons, including transcription factors, small molecules, and microRNAs, with a focus on different types of cells.. While reprogramming somatic cells into neurons holds the potential for understanding neurological diseases and developing therapeutic applications, its limitations and risks must be carefully considered. Here, we highlight the potential benefits of somatic cell reprogramming for neurological disease research and therapy. This review contributes to the field by providing a comprehensive overview of the various techniques used to generate neurons by cellular reprogramming and discussing their potential applications. [ABSTRACT FROM AUTHOR]

The surfaces of various immune cells are rich in glycan chains, including the sialic-acid-binding immunoglobulin-like lectins (Siglecs) family. As an emerging glyco-immune checkpoint, Siglecs have the ability to bind and interact with various glycoproteins, thereby eliciting a series of downstream reactions to modulate the immune response. The impact of Siglecs has been extensively studied in tumor immunotherapy. However, research in neurological disorders and neurological diseases is very limited, and therapeutic options involving Siglecs need further exploration. Siglecs play a crucial role in the development, homeostasis, and repair processes of the nervous system, especially in degenerative diseases. This review summarizes studies on the immunomodulatory role mediated by Siglecs expressed on different immune cells in various neurological disorders, elucidates how dysregulated sialic acid contributes to several psychiatric disorders, and discusses the progress and limitations of research on the treatment of neurological disorders. [Display omitted] [ABSTRACT FROM AUTHOR]

The author comments on a review of studies on neuroelectric correlates relating to human sexuality, which references a research paper by A. Ziogas et al., published in a 2020 issue of "Archives of Sexual Behavior." It discusses the insights offered by Ziogas' team regarding limitations and directions for future inquiry of the subject, the selection of sexual stimuli and comparison stimuli, and a comparison between responses to sexual stimuli and sexual processing.

The ethical recruitment of participants with neurological disorders in clinical research requires obtaining initial and ongoing informed consent. The purpose of this study is to characterize barriers faced by research personnel in obtaining informed consent from research participants with neurological disorders and to identify strategies applied by researchers to overcome those barriers. This study was designed as a web-based survey of US researchers with an optional follow-up interview. A subset of participants who completed the survey were selected using a stratified purposeful sampling strategy and invited to participate in an in-depth qualitative interview by phone or video conference. Data were analyzed using a mixed methods approach, including content analysis of survey responses and thematic analysis of interview responses. Over 1 year, 113 survey responses were received from US research personnel directly involved in obtaining informed consent from participants in neurological research. Frequently identified barriers to informed consent included: cognitive and communication impairments (e.g. aphasia), unrealistic expectations of research participants, mistrust of medical research, time constraints, literacy barriers, lack of available social support, and practical or resource-related constraints. Strategies to enhance informed consent included: involving close others to support participant understanding of study-related information, collaborating with more experienced research personnel to facilitate training in obtaining informed consent, encouraging participants to review consent forms in advance of consent discussions, and using printed materials and visual references. Beyond conveying study-related information, researchers included in this study endorsed ethical responsibilities to support deliberation necessary to informed consent in the context of misconceptions about research, unrealistic expectations, limited understanding, mistrust, and/or pressure from close others. Findings highlight the importance of training researchers involved in obtaining informed consent in neurological research to address disease-specific challenges and to support the decision-making processes of potential research participants and their close others. [ABSTRACT FROM AUTHOR]

We present here new amperometric electrodes for the selective and quantitative detection of acetylcholine. The detection was achieved based on the electrodeposition of a carbon electrode with poly(3,4-ethylenedioxythiophene) (PEDOT) followed by the drop-casting of an ionophore-doped poly(vinyl) chloride (PVC) membrane. This work paves the way for future applied research to study neurological disorders. [ABSTRACT FROM AUTHOR]

A disconnect has developed over the past two decades between neurological and neuroscientific research, which have seen notable innovation and development, and our increasing understanding of the role of social and commercial determinants of health, including the health of the nervous system. Over the next two decades, grounding neurological research in public health and epidemiological principles can bring about a paradigm shift, away from reductionism, over-medicalisation, and health inequities towards neurological research that reduces inequalities and has true relevance to the populations it aims to serve. People who are involved in neurological and neuroscientific research and practice, as clinicians, researchers, publishers, and funders, can create change by being more aware of the social and commercial determinants of health, reprioritising research funding, and advocating for greater neurological health equity. [ABSTRACT FROM AUTHOR]

Albert Wojciech Adamkiewicz (1850–1821) was a Polish neurologist and researcher who is best known for his description of the so-called Adamkiewicz-artery. In contrast to his achievements in neurology, his research in psychiatry from his time in Vienna (1891–1921) is commonly overlooked. We examined all titles of his publications from 1891 to 1921 and provided a close reading of those works that were related to his research on the neural basis of mental phenomena and disorders. We demonstrate that, in later stages of his scientific career, Adamkiewicz critically engaged with contemporary positions in psychiatry and the psychogenic explanation of mental disorders. He developed a theory based on his neurological research, correlating central theorems of late-nineteenth-century psychiatry to neural networks in the human cortex. These achievements make him a historical forerunner of neuropsychiatric concepts of mental phenomena and disorders. [ABSTRACT FROM AUTHOR]

Serotonin 5-HT 1A receptor agonists are prime candidates for CNS drug discovery due to their involvement physiological and pathological processes relevant to neurology and psychiatry. However, the lack of target specificity of many previously characterized agonists has long been a barrier to pharmacological and therapeutic progress. Some of the obstacles may be overcome through the recent concept of biased agonism, which has attracted considerable attention to the development of novel chemical entities at 5-HT, and particularly 5-HT 1A receptors, by specifically targeting intracellular signalling pathways that may themselves be linked to specific brain regions and therapeutic indications. There is now abundant translational data demonstrating distinct molecular and functional pharmacological signatures between different 5-HT 1A receptor agonists, opening new opportunities for research in neurology and psychiatry. Nevertheless, important limitations need to be overcome, including understanding the precise molecular basis for biased agonism, the need for improved translatable models, and the currently limited clinical data on biased agonists. Here, we review the current limits of our knowledge of 5-HT 1A receptor biased agonists and the limitations of available pharmacological tools, counterbalanced by the translational possibilities and therapeutic perspectives opened by novel, highly selective 5-HT1A receptor drug-candidates. This article is part of the Special Issue on "Ligand Bias". • Serotonin 5-HT 1A receptor agonists are prime candidates for CNS drug discovery. • The lack of specificity of classical agonists has long been a barrier to pharmacological progress. • The recent concept of 5-HT 1A biased agonism implies targeting specific brain regions for different therapeutic indications. • The current limitations of knowledge on biased agonism are balanced by their translational potential and therapeutic promise. [ABSTRACT FROM AUTHOR]

The original article can be found online at https://doi.org/10.1007/s00415-023-12012-6.Correction to: Journal of Neurology (2024) 271:211–230https://doi.org/10.1007/s00415-023-12012-6In the original version of this article, in table 3 hyperlinks in the tool description are missing.The original article has been corrected.By Vasco Ribeiro Ferreira; Esther Metting; Joshua Schauble; Hamed Seddighi; Lise Beumeler and Valentina GalloReported by Author; Author; Author; Author; Author; Author [Extracted from the article]

The blood–brain barrier (BBB) is an essential structure for the maintenance of brain homeostasis. Alterations to the BBB are linked with a myriad of pathological conditions and play a significant role in the onset and evolution of neurodegenerative diseases, including Alzheimer's disease. Thus, a deeper understanding of the BBB's structure and function is mandatory for a better knowledge of neurodegenerative disorders and the development of effective therapies. Because studying the BBB in vivo imposes overwhelming difficulties, the in vitro approach remains the main possible way of research. With many in vitro BBB models having been developed over the last years, the main aim of this review is to systematically present the most relevant designs used in neurological research. In the first part of the article, the physiological and structural–functional parameters of the human BBB are detailed. Subsequently, available BBB models are presented in a comparative approach, highlighting their advantages and limitations. Finally, the new perspectives related to the study of Alzheimer's disease with the help of novel devices that mimic the in vivo human BBB milieu gives the paper significant originality. [ABSTRACT FROM AUTHOR]

The article focuses on psychiatric and neurological studies that have been purportedly found that frequent internet users of information technology incur the decline in mental health. Topics include highlights on the severity of mental health problems driven by attention capitalism with the economics of internet use and information technology landscape; and tech monopolists inflict actual costs on users while degrading the quality of tech markets with contemporary antitrust.

Objective: To design a physician and patient derived tool, the Adverse Event Unit (AEU), akin to currency (e.g. U.S. Dollar), to improve AE burden measurement independent of any particular disease or medication class. Patients/Methods: A Research Electronic Data Capture (REDCap) online survey was administered to United States physicians with board certification or board eligibility in general neurology, subspecialty neurology, primary care internal medicine or family medicine, subspecialty internal medicine, general pediatrics, and subspecialty pediatrics. Physicians assigned value to 73 AE categories chosen from the Common Terminology Criteria of Adverse Events (CTCAE) relevant to neurologic disorder treatments. An online forced choice survey was administered to non-physician, potential patients, through Amazon Mechanical Turk (MTurK) to weight the severity of the same AE categories. Physician and non-physician data was combined to assign value to the AEU. Surveys completed between 1/2017 and 3/2019. Results: 363 physicians rated the 73 AE categories derived from CTCAE. 660 non-physicians completed forced choice experiments comparing AEs. The AEU provides 0–10, weighted values for the AE categories studied that differ from the ordinal 1–4 CTCAE scale. For example, CTCAE severe diabetes (category 4) is assigned an AEU score of 9. Although non-physician input changed physician assigned AEU values, there was general agreement among physicians and non-physicians about severity of AEs. Conclusion: The AEU has promise to be a useful, practical tool to add precision to AE burden measurement in the clinic and in comparative efficacy research with neurology patients. AEU utility will be assessed in planned comparative efficacy clinical trials. [ABSTRACT FROM AUTHOR]

The detection of Inferior Alveolar Nerve Canal (IAC) plays major and crucial role in dental surgical procedures to avoid damage to IAC during the course of treatment. Exact visualization and detection of IAC is necessary for precise surgery planning to prevent IAC damage. The proposed method comprises of three stages namely, novel edge enhancement, candidate classification and candidate pixel clustering to detect the IAC. For better visualization of IAC, initially the edges of dental OPG images are enhanced using a novel structural filter. Candidate regions are selected from the enhanced image by the proposed Multi Hidden Layer Extreme Learning Machine Artificial Neural Network (MELMANN) model driven by combined regional features such as Histogram of Gradients (HOG), Local Binary Pattern (LBP) and Gray Level Co‐occurrence Matrix (GLCM). Consequently the candidate region pixels are clustered by a Self‐Organising Map‐based Neural Network (SOM ‐ NNC) along with active contour method to detect the IAC completely. Experimental results show that this method effectively delineated the IAC with the Dice coefficient of 0.854 ± 0.05.Therefore, the proposed method has high potential in clearly visualizing IAC to avoid neurological sensory disorders in oral and maxillofacial surgery and implantology and it provides better prediagnostic approach to the surgeons. [ABSTRACT FROM AUTHOR]

Objective: Multiverse analysis provides an ideal tool for understanding how inherent, yet ultimately arbitrary methodological choices impact the conclusions of individual studies. With this investigation, we aimed to demonstrate the utility of multiverse analysis for evaluating generalisability and identifying potential sources of bias within studies employing neurological populations. Methods: Multiverse analysis was used to evaluate the robustness of the relationship between post-stroke visuospatial neglect and poor long-term recovery outcome within a sample of 1113 (age = 72.5, 45.1% female) stroke survivors. A total of 25,600 t-test comparisons were run across 400 different patient groups defined using various combinations of valid inclusion criteria based on lesion location, stroke type, assessment time, neglect impairment definition, and scoring criteria across 16 standardised outcome measures. Results: Overall, 33.9% of conducted comparisons yielded significant results. 99.9% of these significant results fell below the null specification curve, indicating a highly robust relationship between neglect and poor recovery outcome. However, the strength of this effect was not constant across all comparison groups. Comparisons which included < 100 participants, pre-selected patients based on lesion type, or failed to account for allocentric neglect impairment were found to yield average effect sizes which differed substantially. Similarly, average effect sizes differed across various outcome measures with the strongest average effect in comparisons involving an activities of daily living measure and the weakest in comparisons employing a depression subscale. Conclusions: This investigation demonstrates the utility of multiverse analysis techniques for evaluating effect robustness and identifying potential sources of bias within neurological research. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has had a profound impact on neuroscientists, including those involved in translational research. In this NeuroView, we discuss the positive and negative effects of the pandemic on preclinical research and clinical studies in humans. The COVID-19 pandemic has had a profound impact on neuroscientists, including those involved in translational research. In this NeuroView, Snider and Holtzman discuss the positive and negative effects of the pandemic on preclinical research and clinical studies in humans. [ABSTRACT FROM AUTHOR]

Background and purpose: The COVID‐19 (SARS‐CoV‐2) outbreak has disrupted residency programmes due to university and hospitals' priorities to face this emergency at all cost. Most research projects and clinical trials were temporarily stopped or postponed. The Resident and Research Fellow Section (RRFS) of the European Academy of Neurology (EAN) has decided to assess the impact of the COVID‐19 pandemic on neurology training. Methods: All EAN RRFS members were invited to fill out an online questionnaire of 40 items concerning their clinical involvement during the COVID‐19 emergency, and the impact of the pandemic on their training (Appendix S1). Results: Of the 227 RRFS members who completed the questionnaire, 222 were from Europe, and of those 111 were from Portugal, Italy or France. Responders highlighted that severe restrictions have been imposed to face this pandemic, including reduction of inpatient beds, prohibition of in‐person visits and limitation to hospital access for patients' relatives. This was accompanied by an increase in email correspondence and phone calls with 50% of countries allowing telemedicine to reach outpatients. Seventy‐nine per cent of the respondents felt that the pandemic will probably have a serious impact on their training and career. Conclusion: The pandemic led to a disruption of neurology activities, including medical training and research. The long‐run impact of these changes remains unknown, but it will probably change the way neurology practice and training will be organized for future generations. [ABSTRACT FROM AUTHOR]

Enzyme handling and utilization bears many challenges such as their limited stability, intolerance of organic solvents, high cost, or inability to reuse. Most of these limitations can be overcome by enzyme immobilization on the surface of solid support. In this work, the recombinant form of human cholinesterases and monoamine oxidases as important drug targets for neurological diseases were immobilized on the surface of magnetic non-porous microparticles by a non-covalent bond utilizing the interaction between a His-tag terminus on the recombinant enzymes and cobalt (Co2+) ions immobilized on the magnetic microparticles. This type of binding led to targeted enzyme orientation, which completely preserved the catalytic activity and allowed high reproducibility of immobilization. In comparison with free enzymes, the immobilized enzymes showed exceptional stability in time and the possibility of repeated use. Relevant K m , V max , and IC 50 values using known inhibitors were obtained using particular immobilized enzymes. Such immobilized enzymes on magnetic particles could serve as an excellent tool for a sustainable approach in the early stage of drug discovery. [Display omitted] • His-tagged ChEs & MAOs enzymes immobilization on magnetic particles via IMAC. • Enzymes retained catalytic properties post-immobilization. • Enhanced stability, enabling enzyme reusability. • Immobilized ChEs & MAOs application for facile inhibition assays. • Sustainable drug discovery with magnetic particle-immobilized enzymes. [ABSTRACT FROM AUTHOR]

How do we know that we can trust our viewpoints, our dogmatic principles and our religious convictions to constitute veracity, if not truth? Where can an arbiter be found for our deliberations to establish the trustworthiness of our viewpoints or belief systems, when we differ one from the other on religious matters, and in the context of religious conviction also differ in political and social endeavours? Van Huyssteen deserves commendation for his contribution to this discourse in developing the concept of a postfoundationalist epistemology in an attempt to justify theology's integrity, and endorse theology's public voice within our highly complex and challenging world. He suggests that the concept of human uniqueness might be the common denominator in the contributions of theology (in its specific understanding of the unique status of humans in God's creation) and science (in its understanding of the unique stature of Homo sapiens in terms of biological evolution). However, the author, in this article, argues that given the radically diverse disciplines of science in our highly developed technological – and indeed within our current Covid-dominated context (on the one hand) and the pre-scientific context of religion (on the other hand), it becomes increasingly difficult to imagine how it can remain possible to find something like a common issue, a shared problem, a kind of mutual concern or even a shared overlapping research trajectory that might benefit precisely from this envisaged interdisciplinary dialogue. Is it possible that 'alone in this world' could mean something different than what Van Huyssteen suggests? Intradisciplinary and/or interdisciplinary implications: How do we know that we can trust our viewpoints, and our religious convictions to constitute truth? Van Huyssteen develops the concept of a postfoundationalist epistemology in an attempt to justify theology's integrity within the discourse with science. However, the author in this article argues that it has become increasingly difficult for systematic theology to find a shared overlapping research trajectory that might benefit this interdisciplinary dialogue. [ABSTRACT FROM AUTHOR]

Background and purpose: To provide an overview on the status of clinical research in neurology in Germany. Methods: German university hospitals, nonuniversity hospitals, and neurological medical practices were surveyed regarding their clinical research activities during the period 2013 to 2017. Results: Fifty percent of university hospitals, 10.6% of nonuniversity hospitals, and 5.2% of medical practices in Germany responded to our questionnaire. More than 80% of the clinical studies conducted have been phase III/IV and noninterventional trials (NISs), whereas <1% have been phase I and 3.5% investigator‐initiated trials (IITs). University hospitals have conducted most of the phase II–IV trials. NISs have been predominantly performed by medical practices. Fifty‐six percent of the university hospitals and less of the nonuniversity institutions confirmed the implementation of standard operating procedures (SOPs). In university hospitals, on average, 11 physicians had acquired a good clinical practice certificate. Overall, 43% of all trials have been performed in neuroimmunology. Conclusions: The status of clinical research in neurology in Germany is predominated by NISs and late‐phase trials, potentially due to a general lack of easily accessible funding, which leads to a highly competitive environment and fewer opportunities to perform early‐phase clinical trials as well as IITs. Our results indicate that there is substantial need for structured support for creating and implementing SOPs to maintain quality standards and guarantee uniformity of performance. This survey assessed many aspects of clinical research and serves as guidance for providing ideas for structured improvement of clinical research in neurology in Germany. [ABSTRACT FROM AUTHOR]

Body psychotherapy has been strongly influenced by far-reaching research in neurology. While these influences are easily justifiable, there has been a concomitant influence of moving away from the body to a brainbased model. Concurrently, research in the manual therapies in connective tissue, and specifically fascia, has revealed how and why body-based techniques can have such a profound effect on a patient. Taking this further, this research has revealed a heretofore unknown communication system among the three nervous systems and the body, resulting in the formulation of a more integrated body/mind model. I will highlight the growing connections between connective tissue (CT) and the three nervous systems in the body and show the role CT plays in these connections. The main theme is connective tissue's plasticity; its ability to adapt and readapt to changing conditions locally and systemically, externally and internally, as well as physically and emotionally. The plasticity of CT lies at the heart of any therapy that involves either movement or touch. It is the biological, body-based means of body psychotherapy's efficacy. [ABSTRACT FROM AUTHOR]

Background: Published research informs international healthcare, yet only a few studies have assessed the representation of authors, editors, and research from developing countries in biomedical journals.Methods: We reviewed all research articles published in five high-ranking peer-reviewed neurology journals (The Lancet Neurology, Acta Neuropathologica, Nature Reviews Neurology, Brain and Annals of Neurology) in 2010 and 2019 to determine the extent of contributions of authors, editors and research from developing countries, and the degree of international research collaboration between developed and developing countries.Results: First authorship was attributed to authors from developing countries in only 2% (11/729) of research articles in 2010 and 3% (19/647) of research articles in 2019. All 144 editorial board members in 2019 were from developed countries. International research collaboration between developing and developed countries accounted for only 4% (30/729) of all research articles in 2010 and 6% (40/647) of all research articles in 2019.Conclusions: There is urgent need for strategies to support high-quality and contextually appropriate biomedical research in developing countries. Supporting high quality and contextually appropriate biomedical research now is necessary for developing countries to meet the rising healthcare needs of their populations in the future. [ABSTRACT FROM AUTHOR]

Background: The past decades have seen a transformational shift in the understanding and treatment for neurological diseases affecting infants and children. These advances have been driven in part by the pediatric neurology physician-scientist workforce and its efforts. However, pediatric neurology research faces substantial challenges from internal and external forces including work-life balance demands, COVID-19 pandemic effects, and research funding. Understanding the impact of these challenges on the perceptions, planning, and careers of pediatric neurology physician-scientists is needed to guide the research mission.Methods: Our objective was to survey the research challenges, goals, and priorities of pediatric neurologists. In 2020 we conducted a cross-sectional, 28-question survey emailed to 1,775 members of the Child Neurology Society.Results: One hundred fifty-one individuals responded to the survey. Most respondents were grant investigators (52%) and conducted clinical research (69%). Research areas included epilepsy (23%), neurodevelopmental and autism (16%), neurocritical care and stroke (11%), neurogenetics and neurometabolics (9%), neonatal neurology (8%), and others. The most common funding source was the National Institutes of Health (37%). Shared major research concerns were funding, utilization of remote technology, overcoming disparities, natural history and multicenter studies, global neurology, and diversification of the research portfolio. Commitment to continuing and increasing research efforts was evident.Conclusions: Our survey demonstrates obstacles for physician-scientist researchers in pediatric neurology, but it also shows optimism about continued opportunity. Creative approaches to address challenges will benefit the research mission, maximize the current and future pool of researchers, and help improve the lives of children with neurological disorders. [ABSTRACT FROM AUTHOR]

Medical students interested in neurosurgery are increasingly involved in research, and research conferences have proven valuable for developing medical research experience and exposure. A research conference was designed for medical students interested in neurosurgery to present research. Our team designed an annual research conference at the Warren Alpert Medical School of Brown University in conjunction with the Neurosurgery and Neurology Departments. In February 2019, we hosted the first Student Neurosurgical and Neurological Research Conference (SNRC), the first national research conference, to our knowledge, designed for medical students to present neurosurgical research in the United States. The conference consisted of student poster/oral presentations, keynote speeches from clinical faculty, and surgical skills workstations. In February 2020, we hosted the second SNRC. After each conference, participants (n = 55) completed a survey to assess student perspectives of the conference. Fifty-five medical students from around the nation attended the conferences to present their research. One hundred percent of participants affirmed that the conference fulfilled their primary reason for attending, which for most (54.5%) was the opportunity to present research. Thematic analysis revealed that students especially appreciated the "lower stress environment" and "opportunity to get feedback on their research." Notably, 97.6% of students felt the conference strengthened or increased their interest in neurosurgery. Participants felt that the SNRC was a valuable opportunity to present research in an environment conducive for practice and improvement. Research conferences primarily for medical students may support the development of young researchers while increasing and strengthening interest in the field of neurosurgery. [ABSTRACT FROM AUTHOR]

Tea polyphenols (TP) are important functional components in tea. TP can regulate the composition of human intestinal flora, meanwhile, TP can be bio‐transformed by the intestinal microbiota, resulting in relative metabolites, which prevent nerve damage, promote neurocognition, and increase resistance to oxidative stress. In recent years, cerebral nerves have become a hot topic of research, and studies have marked the importance of microbial flora and TP in protecting cerebral nerves. This paper reviews the effects of TP on intestinal microflora and the microbial degradation of TP. Furthermore, the potential effects of TP on cerebral nerves have been highlighted. Practical applications: Neuroscience studies are primarily focused on discerning the functional mechanism of the nervous system. The functional role of intestinal microbiota in host physiology regulation, especially neurological functions, has become a hotspot for neurological research. TP play a vital role in maintaining the steady status of intestinal flora and protecting cerebral nerve damage. An in‐depth understanding of the TP and intestinal microbiota interaction, its implication on cerebral nerve protection, and the associated underlying mechanism will allow us to expand the therapeutic applications of TP. [ABSTRACT FROM AUTHOR]