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Abstract: Background: Among patients with irritable bowel syndrome (IBS), atopic disease has been proposed as a common comorbidity increasing the IBS symptom burden. We therefore assessed the prevalence of self‐reported atopy among patients with IBS as compared to non‐IBS controls, and whether atopy and higher serum IgE levels were associated with increased IBS symptom severity. Methods: Levels of total and specific IgE in serum were measured and questionnaires assessing the presence of atopic disease (ie, eczema, asthma, rhinoconjunctivitis, and pollen allergy), gastrointestinal symptom burden, food intolerance, somatic, and psychological symptoms were completed. Key results: In total, 223 patients with IBS and 47 controls participated. Presence of atopic disease was reported in 55% of patients with IBS compared to 40% of controls (P = .07). IBS patients with atopic manifestations (N = 123) had higher total serum IgE levels (median 31 vs 16 kUA/L, P < .001) and higher prevalence of self‐reported food intolerance (28% vs 9%, P = .002) than non‐atopic IBS patients (N = 100), respectively, but no major difference in gastrointestinal or psychological symptom burden was noted. However, severe somatic symptoms were more common among atopic than non‐atopic patients with IBS (38% vs 27%, P = .028). We found no associations between self‐reported atopy and IBS symptom severity using linear regression models. Conclusions & Inferences: Atopic disease is common in patients with IBS, but that is also true for subjects without IBS. The presence of atopic disease in IBS is associated with self‐reported food intolerance and somatic symptom severity, but unrelated to IBS symptom severity. [ABSTRACT FROM AUTHOR]